Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity

Nature Neuroscience, Год журнала: 2022, Номер 25(12), С. 1706 - 1713

Опубликована: Ноя. 28, 2022

Язык: Английский

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Voltage compartmentalization in dendritic spines in vivo

Science, Год журнала: 2021, Номер 375(6576), С. 82 - 86

Опубликована: Ноя. 11, 2021

Dendritic spines’ electrical function? spines are small protrusions that cover the dendrites of most neurons in brain. Their properties still controversially discussed. Cornejo et al . used an array techniques to investigate degree voltage attenuation by dendritic spine necks pyramidal mouse neocortex. Spines not only synchronously depolarized response backpropagating action potentials, but local and transient depolarization also occurred. Isolated individual reflected localized synaptic activation. A significant gradient between dendrite indicated may constitute elementary electric compartments. The neck resistance is thus negligible substantially contribute regulation efficacy central nervous system. —PRS

Язык: Английский

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An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress

Molecular Psychiatry, Год журнала: 2021, Номер 26(11), С. 6237 - 6252

Опубликована: Май 25, 2021

Abstract Psychological stress affects a wide spectrum of brain functions and poses risks for many mental disorders. However, effective therapeutics to alleviate or revert its deleterious effects are lacking. A recently synthesized psychedelic analog tabernanthalog (TBG) has demonstrated anti-addictive antidepressant potential. Whether TBG can rescue stress-induced affective, sensory, cognitive deficits, how it may achieve such by modulating neural circuits, remain unknown. Here we show that in mice exposed unpredictable mild (UMS), administration single dose decreases their anxiety level rescues deficits sensory processing as well flexibility. Post-stress treatment promotes the regrowth excitatory neuron dendritic spines lost during UMS, baseline neuronal activity, enhances whisking-modulation activity somatosensory cortex. Moreover, calcium imaging head-fixed performing whisker-dependent texture discrimination task shows novel textures elicit responses from greater proportion neurons cortex than do familiar textures. Such differential response is diminished UMS restored TBG. Together, our study reveals on cortical circuit patterns demonstrate combats detrimental basal stimulus-dependent networks.

Язык: Английский

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The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 35

Опубликована: Апрель 1, 2024

Abstract In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration modelling at multiple scales—from molecules to the whole brain. Major are emerging intersection of neuroscience with technology computing. This science combines high-quality research, across scales, culture multidisciplinary large-scale collaboration, translation into applications. As pioneered in Europe’s Human Brain Project (HBP), systematic approach will be essential for meeting coming decade’s pressing medical technological challenges. The aims this paper to: develop concept decade digital discuss community large, identify points convergence, derive therefrom scientific common goals; provide framework current future development EBRAINS, infrastructure resulting from HBP’s work; inform engage stakeholders, funding organisations institutions regarding research; address transformational potential comprehensive models artificial intelligence, including machine learning deep learning; outline collaborative that integrates reflection, dialogues, societal engagement on ethical opportunities challenges as part research.

Язык: Английский

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Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery

Journal of Neuroscience, Год журнала: 2024, Номер 44(1), С. e1051232024 - e1051232024

Опубликована: Янв. 3, 2024

Despite the increasing incidence and prevalence of amputation across globe, individuals with acquired limb loss continue to struggle functional recovery chronic pain. A more complete understanding motor sensory remodeling peripheral central nervous system that occurs postamputation may help advance clinical interventions improve quality life for loss. The purpose this article is first provide background context on then a comprehensive review known neural adaptations from both animal models human trials. Finally, bridges gap between basic science researchers clinicians treat by explaining how current treatments restore function modulate phantom pain using underlying described above. This should encourage further development novel neurological targets postamputation. Significance Statement In United States, 1.6 million people live loss; number expected than double 2050. Improved surgical procedures enhance recovery, new prosthetics interfaces can replace missing limbs those communicate bidirectionally brain. These advances have been fairly successful, but still most patients experience persistent problems like pain, others discontinue prostheses instead learning use them daily. problematic patient outcomes be due in part lack consensus among regarding plasticity mechanisms occur brain after injuries. Here we results model studies bridge clinicalbasic gap.

Язык: Английский

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Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 18, 2025

Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice expression of the autism/intellectual disability gene, Syngap1, cortical excitatory neurons is formation somatomotor networks promote SMI-mediated perception. Cortical Syngap1 was necessary and sufficient setting tactile sensitivity, sustaining object exploration, promoting learning. Mice with deficient exhibited impaired neural dynamics induced by exploratory touches within cortical-thalamic network promotes attention Disrupted neuronal were associated circuit-specific long-range synaptic connectivity abnormalities. Our data support model where autonomous abilities assembly circuits integrate temporally-overlapping sensory motor signals, process attention. These provide systems-level insights into robust association between ability.

Язык: Английский

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Permanent tactile sensory loss reduces neuronal activity in the amygdala and ventral hippocampus and alters anxiety-like behaviors.

Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115456 - 115456

Опубликована: Янв. 1, 2025

Язык: Английский

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Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1

eLife, Год журнала: 2021, Номер 10

Опубликована: Апрель 14, 2021

Sensory-guided limb control relies on communication across sensorimotor loops. For active touch with the hand, longest loop is transcortical continuation of ascending pathways, particularly lemnisco-cortical and corticocortical pathways carrying tactile signals via cuneate nucleus, ventral posterior lateral (VPL) thalamus, primary somatosensory (S1) motor (M1) cortices to reach corticospinal neurons influence descending activity. We characterized excitatory connectivity along this pathway in mouse. In leg, disynaptic cuneate→VPL→S1 connections excited mainly layer (L) 4 neurons. S1→M1 from L2/3 L5A downstream neurons, which excite The findings provide a detailed new wiring diagram for hand/forelimb-related circuit, delineating basic but complex set cell-type-specific feedforward that selectively extensively engage diverse intratelencephalic projection thereby polysynaptically linking subcortical input cortical output spinal cord.

Язык: Английский

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Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(4)

Опубликована: Янв. 18, 2022

Significance Functional MRI (fMRI) has led to tremendous advancements in brain science by allowing noninvasive mapping of functional regions response various stimuli and resting-state connectivity. Both evoked networks contain multiple that are hierarchically yet reciprocally connected. Therefore, it is critical determine the relative contributions different circuits fMRI findings better understand functions Here, we adopted local silencing with optogenetic stimulation suppress downstream successfully dissected responses at circuit level. This approach opens an avenue for understanding brain-wide, population-based neural circuits, investigations reorganization caused neuropathological modifications learning individual animals.

Язык: Английский

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Layer 1 neocortex: Gating and integrating multidimensional signals

Neuron, Год журнала: 2023, Номер 112(2), С. 184 - 200

Опубликована: Окт. 31, 2023

Язык: Английский

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