Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 12, 2024
Abstract
Sirtuins,
which
are
NAD
+
-dependent
class
III
histone
deacetylases,
involved
in
various
biological
processes,
including
DNA
damage
repair,
immune
inflammation,
oxidative
stress,
mitochondrial
homeostasis,
autophagy,
and
apoptosis.
Sirtuins
essential
regulators
of
cellular
function
organismal
health.
Increasing
evidence
suggests
that
the
development
age-related
diseases,
kidney
is
associated
with
aberrant
expression
sirtuins,
regulation
sirtuins
activity
can
effectively
improve
delay
progression
disease.
In
this
review,
we
summarise
current
studies
highlighting
role
renal
diseases.
First,
discuss
sirtuin
family
members
their
main
mechanisms
action.
We
then
outline
possible
roles
cell
types
Finally,
compounds
activate
or
inhibit
consequently
ameliorate
conclusion,
targeted
modulation
a
potential
therapeutic
strategy
for
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 29, 2022
Sirtuins
(SIRTs)
are
nicotine
adenine
dinucleotide(+)-dependent
histone
deacetylases
regulating
critical
signaling
pathways
in
prokaryotes
and
eukaryotes,
involved
numerous
biological
processes.
Currently,
seven
mammalian
homologs
of
yeast
Sir2
named
SIRT1
to
SIRT7
have
been
identified.
Increasing
evidence
has
suggested
the
vital
roles
members
SIRT
family
health
disease
conditions.
Notably,
this
protein
plays
a
variety
important
cellular
biology
such
as
inflammation,
metabolism,
oxidative
stress,
apoptosis,
etc.,
thus,
it
is
considered
potential
therapeutic
target
for
different
kinds
pathologies
including
cancer,
cardiovascular
disease,
respiratory
other
Moreover,
identification
modulators
exploring
functions
these
prompted
increased
efforts
discover
new
small
molecules,
which
can
modify
activity.
Furthermore,
several
randomized
controlled
trials
indicated
that
interventions
might
affect
expression
human
samples,
supplementation
diverse
impact
on
physiological
function
participants.
In
review,
we
introduce
history
structure
family,
discuss
molecular
mechanisms
elaborate
regulatory
SIRTs
summarize
inhibitors
activators,
review
related
clinical
studies.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Ноя. 23, 2021
The
morbidity
and
mortality
of
autoimmune
diseases
(Ads)
have
been
increasing
worldwide,
the
identification
novel
therapeutic
strategies
for
prevention
treatment
is
urgently
needed.
Sirtuin
1
(SIRT1),
a
member
class
III
family
nicotinamide
adenine
dinucleotide
(NAD
+
)-dependent
histone
deacetylases,
has
reported
to
participate
in
progression
several
diseases.
SIRT1
also
regulates
inflammation,
oxidative
stress,
mitochondrial
function,
immune
responses,
cellular
differentiation,
proliferation
metabolism,
its
altered
functions
are
likely
involved
Ads.
Several
inhibitors
activators
shown
affect
development
may
represent
target
these
diseases,
small
molecules
or
natural
products
that
modulate
potential
agents.
In
present
review,
we
summarize
current
studies
biological
role
pathogenesis
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 20, 2023
Hypoxia,
characterized
by
reduced
oxygen
concentration,
is
a
significant
stressor
that
affects
the
survival
of
aerobic
species
and
plays
prominent
role
in
cardiovascular
diseases.
From
research
history
milestone
events
related
to
hypoxia
development
diseases,
The
"hypoxia-inducible
factors
(HIFs)
switch"
can
be
observed
from
both
temporal
spatial
perspectives,
encompassing
occurrence
progression
(gradual
decline
concentration),
acute
chronic
manifestations
hypoxia,
geographical
characteristics
(natural
selection
at
high
altitudes).
Furthermore,
signaling
pathways
are
associated
with
natural
rhythms,
such
as
diurnal
hibernation
processes.
In
addition
innate
selection,
it
has
been
found
epigenetics,
postnatal
factor,
profoundly
influences
hypoxic
response
within
system.
Within
this
intricate
process,
interactions
between
different
tissues
organs
system
other
systems
context
have
established.
Thus,
time
summarize
construct
multi-level
regulatory
framework
mechanisms
diseases
for
developing
more
therapeutic
targets
make
reasonable
advancements
clinical
research,
including
FDA-approved
drugs
ongoing
trials,
guide
future
practice
field
Abstract
The
thymus
is
the
primary
immune
organ
responsible
for
generating
self‐tolerant
and
immunocompetent
T
cells.
However,
gradually
involutes
during
early
life
resulting
in
declined
naïve
T‐cell
production,
a
process
known
as
age‐related
thymic
involution.
Thymic
involution
has
many
negative
impacts
on
function
including
reduced
pathogen
resistance,
high
autoimmunity
incidence,
attenuated
tumor
immunosurveillance.
Age‐related
leads
to
gradual
reduction
cellularity
stromal
microenvironment
disruption,
loss
of
definite
cortical‐medullary
junctions,
cortical
epithelial
cells
medullary
cells,
fibroblast
expansion,
an
increase
perivascular
space.
compromised
aged
individuals
substantially
disturbs
thymocyte
development
differentiation.
regulated
by
transcription
factors,
micro
RNAs,
growth
cytokines,
other
factors.
In
this
review,
we
summarize
current
understanding
mechanisms
effects.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 14279 - 14279
Опубликована: Сен. 19, 2023
Aging
is
considered
the
deterioration
of
physiological
functions
along
with
an
increased
mortality
rate.
This
scientific
review
focuses
on
central
importance
genomic
instability
during
aging
process,
encompassing
a
range
cellular
and
molecular
changes
that
occur
advancing
age.
In
particular,
this
revision
addresses
genetic
epigenetic
alterations
contribute
to
instability,
such
as
telomere
shortening,
DNA
damage
accumulation,
decreased
repair
capacity.
Furthermore,
explores
aging,
including
modifications
histones,
methylation
patterns,
role
non-coding
RNAs.
Finally,
discusses
organization
chromatin
its
contribution
heterochromatin
loss,
remodeling,
in
nucleosome
histone
abundance.
conclusion,
highlights
fundamental
plays
process
underscores
need
for
continued
research
into
these
complex
biological
mechanisms.
Medicinal Research Reviews,
Год журнала:
2020,
Номер
41(2), С. 1089 - 1137
Опубликована: Дек. 16, 2020
Abstract
The
biological
functions
of
sirtuin
6
(SIRT6;
e.g.,
deacetylation,
defatty‐acylation,
and
mono‐ADP‐ribosylation)
play
a
pivotal
role
in
regulating
lifespan
several
fundamental
processes
controlling
aging
such
as
DNA
repair,
gene
expression,
telomeric
maintenance.
Over
the
past
decades,
aberration
SIRT6
has
been
extensively
observed
diverse
life‐threatening
human
diseases.
In
this
comprehensive
review,
we
summarize
critical
roles
onset
progression
diseases
including
cancer,
inflammation,
diabetes,
steatohepatitis,
arthritis,
cardiovascular
diseases,
neurodegenerative
viral
infections,
renal
corneal
injuries,
well
elucidation
related
signaling
pathways.
Moreover,
discuss
advances
development
small
molecule
modulators
activators
inhibitors
their
pharmacological
profiles
toward
potential
therapeutics
for
SIRT6‐mediated
Chemical Science,
Год журнала:
2020,
Номер
12(1), С. 464 - 476
Опубликована: Ноя. 2, 2020
Using
reversed
allosteric
communication,
we
performed
MD
simulations,
MSMs,
and
mutagenesis
experiments,
to
discover
sites.
It
reproduced
the
known
site
for
MDL-801
on
Sirt6
uncovered
a
novel
cryptic
Pocket
X.
