Biomedicines,
Год журнала:
2024,
Номер
12(4), С. 765 - 765
Опубликована: Март 29, 2024
Diabetic
cardiomyopathy
(DCM)
is
the
development
of
myocardial
dysfunction
in
patients
with
diabetes
despite
absence
comorbidities
such
as
hypertension,
atherosclerosis
or
valvular
defect.
The
cardiovascular
complications
poorly
controlled
are
very
well
illustrated
by
U.K.
Prospective
Diabetes
Study
(UKPDS),
which
showed
a
clear
association
between
increasing
levels
glycated
hemoglobin
and
heart
failure
(HF).
incidence
HF
projected
to
increase
significantly,
why
its
proper
diagnosis
treatment
so
important.
Providing
appropriate
therapy
focusing
on
antidiabetic
hypolipemic
consideration
pharmacotherapy
for
reduces
risk
CMD
complications.
Health-promoting
changes
made
low-carbohydrate
diet,
regular
exercise
weight
reduction
also
appear
be
important
achieving
outcomes.
New
hope
therapies
DCM
offered
novel
methods
using
stem
cells
miRNA,
which,
however,
require
more
thorough
research
confirm
their
efficacy.
Physiology,
Год журнала:
2024,
Номер
40(1), С. 000 - 000
Опубликована: Июль 30, 2024
Inflammation
is
an
important
physiological
response
of
the
organism
to
restore
homeostasis
upon
pathogenic
or
damaging
stimuli.
However,
persistence
harmful
trigger
a
deficient
resolution
process
can
evolve
into
state
low-grade,
chronic
inflammation.
This
condition
strongly
associated
with
development
several
increasingly
prevalent
and
serious
conditions,
such
as
obesity,
cancer,
cardiovascular
diseases,
elevating
overall
morbidity
mortality
worldwide.
The
current
pandemic
diseases
underscores
need
address
inflammation,
its
mechanisms,
potential
preventive
measures
limit
widespread
impact.
present
review
discusses
knowledge
research
gaps
regarding
association
between
low-grade
inflammation
focusing
on
digestive
cancer.
We
examine
art
in
selected
aspects
topic
propose
future
directions
approaches
for
field.
Phytomedicine,
Год журнала:
2024,
Номер
126, С. 155441 - 155441
Опубликована: Фев. 10, 2024
The
mitochondrial
unfolded
protein
response
(UPRmt)
is
the
first
line
of
defense
against
dysfunction
in
several
diseases.
Baicalein,
which
an
extract
Scutellaria
baicalensis
Georgi
roots,
exerts
mitoprotective
effects
on
metabolic
disorders
and
cardiovascular
However,
it
remains
unclear
whether
baicalein
alleviates
obesity-induced
cardiac
damage
through
UPRmt.
present
research
designed
to
clarify
role
lipotoxicity-induced
myocardial
apoptosis
investigated
UPRmt-related
mechanism.
In
vitro
experiment,
palmitic
acid
(PA)-treated
AC16
cardiomyocytes
were
established
mimic
injury.
After
pretreatment
cells
with
baicalein,
levels
cell
vitality,
apoptosis,
membrane
potential,
oxidative
stress,
proteins
determined.
Additionally,
treated
ML385
or
siRNA
explore
regulation
UPRmt
by
NRF2
signaling.
vivo
male
db/db
mice
administered
for
8
weeks
used
validate
induced
obesity,
UPRmt,
NRF2-related
pathway.
cardiomyocytes,
PA
dose-dependently
increased
expression
markers
(HSP60,
LONP1,
ATF4,
ATF5).
This
increase
was
accompanied
enhanced
production
ROS,
reduced
elevated
cytochrome
c,
cleaved
caspase-3,
Bax/Bcl2,
eventually
leading
apoptosis.
Baicalein
treatment
reversed
activation
impeded
mitochondrial-mediated
Moreover,
downregulation
its
inhibitor
diminished
baicalein-mediated
signaling
inhibition
triggered
dysfunction.
deficiency
more
intensely
activated
resulting
stress
PA-induced
thus
indicating
that
plays
a
vital
homeostasis
regulation.
study
mice,
inhibited
antioxidant
capacity,
attenuated
NRF2-activated
To
our
best
knowledge,
these
results
provide
insight
inhibits
induce
protective
effect
cardiomyocyte
via
activating
suggest
new
Biomedicines,
Год журнала:
2024,
Номер
12(4), С. 765 - 765
Опубликована: Март 29, 2024
Diabetic
cardiomyopathy
(DCM)
is
the
development
of
myocardial
dysfunction
in
patients
with
diabetes
despite
absence
comorbidities
such
as
hypertension,
atherosclerosis
or
valvular
defect.
The
cardiovascular
complications
poorly
controlled
are
very
well
illustrated
by
U.K.
Prospective
Diabetes
Study
(UKPDS),
which
showed
a
clear
association
between
increasing
levels
glycated
hemoglobin
and
heart
failure
(HF).
incidence
HF
projected
to
increase
significantly,
why
its
proper
diagnosis
treatment
so
important.
Providing
appropriate
therapy
focusing
on
antidiabetic
hypolipemic
consideration
pharmacotherapy
for
reduces
risk
CMD
complications.
Health-promoting
changes
made
low-carbohydrate
diet,
regular
exercise
weight
reduction
also
appear
be
important
achieving
outcomes.
New
hope
therapies
DCM
offered
novel
methods
using
stem
cells
miRNA,
which,
however,
require
more
thorough
research
confirm
their
efficacy.
