Association between parity and gravidity & hypertension and blood pressure: protocol for a systematic review and meta-analysis

BMJ Open, Год журнала: 2025, Номер 15(2), С. e094739 - e094739

Опубликована: Фев. 1, 2025

Introduction Cardiovascular disease is the leading cause of death among women worldwide, and hypertension one most prevalent modifiable risk factors. Parity gravidity, independent pregnancy complications, have each been associated with hypertension, although results are conflicting. Therefore, we propose to estimate association between parity gravidity blood pressure in a systematic review literature. Methods analysis A will be conducted pressure. Electronic databases (Excerpta Medica Database, Ovid MEDLINE, Cochrane Central Register Controlled Trials, Cumulative Index Nursing Allied Health Literature Plus Web Science) searched from inception January 2025. Two investigators independently screen identified abstracts select observational cohort studies, case-control studies randomised controlled trials examining or Extracted data include study population characteristics, comorbidities, parity, incidence changes pressure, quality bias. If there sufficient data, they summarised using random effects meta-analysis pooled ratio odds hypertension. Stratified subgroup analyses used explore potential sources heterogeneity. PROSPERO registration number CRD42024560535.

Язык: Английский

---

Influence of estradiol deficiency on the mineralocorticoid receptor response in postmenopausal women: a cross-sectional study

Climacteric, Год журнала: 2025, Номер unknown, С. 1 - 7

Опубликована: Фев. 10, 2025

Premenopausal women (PreM) have a cardioprotective advantage over postmenopausal (PostM) due to estrogen. The interaction of estrogen with the mineralocorticoid receptor (MR) pathway remains unexplored. This study aimed identify changes in aldosterone, renin and sexual steroid levels MR surrogate biomarkers PostM that may explain blood pressure renal damage. A cross-sectional was carried out 47 normotensive hypertensive Chilean distributed between PreM PostM. Clinical, anthropometric biochemical parameters, including plasma activity (PRA) markers activity, were assessed. had greater systolic (SBP) (p < 0.001) than PreM. negative correlation observed estradiol fractional excretion potassium (FEK) (ρ = -0.29; p 0.023), adjusted for age SBP. Compared PreM, (PostM-HT) showed reduced PRA 0.045) FEK 0.04). Normotensive (Post-NT) exhibited SBP 0.03), neutrophil gelatinase-associated lipocalin (NGAL) 0.04) 0.03) Our results suggest enhanced sensitivity not only PostM-HT, as evidenced by lower elevated FEK, but also PostM-NT, who NGAL levels, activation. These support novel role activation cardiovascular risk women.

Язык: Английский

---

Vascular actions of Ang 1-7 and Ang 1-8 through EDRFs and EDHFs in non-diabetes and diabetes mellitus

Nitric Oxide, Год журнала: 2025, Номер 156, С. 9 - 26

Опубликована: Март 1, 2025

Язык: Английский

---

Sex-specific trends in the global burden and risk factors of atrial fibrillation and flutter from 1990 to 2021

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 8, 2025

Significant sex disparities exist in the burden of atrial fibrillation and flutter. However, comprehensive systematic analysis its global trend by is scarce. The Global Burden Disease Study 2021 was used as data source for analysis. Sex-specific prevalence, incidence, disability-adjusted life years (DALY), mortality rates per 100,000 population from flutter were estimated using Bayesian meta-regression method. Temporal trends average annual percent change (AAPC) age-standardized age-specific burdens across age bands evaluated joinpoint model stratified socio-demographic index (SDI). Sex differences tested pairwise comparison. From 1990 to 2021, DALY rate [from 109.93 (95% uncertainty interval, 88.5 134.72) 112.05 (93.3 135.28), P < 0.001], 4.20 (3.65 4.59) 4.44 (3.94 4.81), 0.001] significantly increased males, while incidence decreased 58.0 (44.98 75.8) 57.11 (46.19 72.14) males (P 0.001). Countries with low low-middle SDI exhibited significant increases prevalence both females (all 0.001), a faster increase females. Across all bands, observed among under 50 showed higher on scale compared males. High systolic blood pressure predominant risk factor contributing flutter-related DALY. Notably, impact high body-mass increasing fast over last three decades, especially Although has substantially increased, different sexes, countries status.

Язык: Английский

---

Simultaneous isolation and culture of endothelial colony-forming cells, endothelial cells and vascular smooth muscle cells from human umbilical cords

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Март 13, 2025

Abstract Background Regulation of the human umbilical circulation under physiological and pathological conditions remains poorly understood. We previously demonstrated that intrauterine growth restriction (IUGR) is associated with sex-specific alterations in circulation. Our data strongly suggest a differential contribution subcellular compartmentation depending on fetal sex, vessel type presence IUGR. therefore developed protocol to isolate culture vascular cells further investigate relative each cell regulation. Methods results Human cords cord blood were collected just after delivery. Mononuclear recovered from using Ficoll gradient cultured obtain endothelial colony-forming (ECFCs). Endothelial (ECs) isolated vein (HUV) arteries (HUAs) by collagenase/dispase digestion, smooth muscle (SMCs) migration explants. All types characterized visualization, analysis biomarkers immunocytofluorescence Western blot. ECFCs also submitted polychromatic flow cytometry analysis. Conclusions This enables simultaneous isolation ECFCs, HUVECs, HUAECs, HUVSMCs HUASMCs same cord. It simpler, faster more cost-effective than other published methods, good success rates. will be helpful regulatory mechanisms implicated study influence sex.

Язык: Английский

---

Sex-Specific Association between Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes: A Post-Hoc Analysis of the SPRINT Trial

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(3)

Опубликована: Март 18, 2025

Systolic blood pressure time in target range (SBP TTR) is a novel metric for control. Previous studies have demonstrated an inverse association between SBP TTR and risks of cardiovascular events, but sex differences never been reported. This study aims to investigate the sex-specific relationship using data from Blood Pressure Intervention Trial (SPRINT). post hoc analysis included 8822 SPRINT participants with at least three follow-up systolic (SBP) measurements within first months. was calculated Rosendaal method linear interpolation. The primary endpoint major adverse cerebrovascular events (MACCE). Cox proportional hazards models restricted cubic splines (RCS) were used assess events. Women accounted 35.3% mean age 68.6 ± 9.5 years, having higher body mass index (p = 0.007) lower compared men < 0.001). In overall population women, each standard deviation (SD) increase associated reduced risk MACCE (adjusted hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.82-0.97; p 0.007, adjusted HR 0.85; CI 0.74-0.99; 0.039, respectively) acute decompensated heart failure 0.86; 0.73-0.99; 0.047, 0.68; 0.51-0.92; 0.011, respectively), while this not observed men. RCS indicated similar trend only when exceeded 39%. Additional adjustments variability yielded outcomes. demonstrates that failure, men, higher, underscoring necessity considering personalized management strategies. NCT01206062, https://www.clinicaltrials.gov/expert-search?term=NCT01206062.

Язык: Английский

---

Sex differences in the sensitization of prenatally programmed hypertension

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 28, 2025

Studies have demonstrated that there are sex differences in the timing of onset and severity prenatally programmed hypertension, with consistently milder phenotypes observed females relative to male offspring. However, root cause(s) for these sex-specific effects is unknown. Activation renin-angiotensin system (RAS), elevated oxidative stress inflammation, sympathetic hyperactivity cardiovascular organs regulatory systems, all involved pathogenesis hypertension. Sex hormones interact prohypertensive systems modulate blood pressure, this interaction may lead a development A more complete understanding functional capabilities their interactions factors offspring, from early life aging, would likely new insights into basis Recently, we discovered also occur sensitization offspring hypertension as by maternal gestational requires brain RAS proinflammatory factors. In review, will discuss possible mechanisms underlying mothers exposed various prenatal insults. These operate at levels periphery central nervous (e.g., vessel, heart, kidney, brain). Understanding responsible sensitized state can help develop therapeutic strategies interrupting vicious cycle transgenerational treating men women differentially maximize efficacy.

Язык: Английский

---

Sex- and age-related differences in kidney function in patients with psoriasis

Опубликована: Май 13, 2025

Background Psoriasis is a prevalent multifactorial chronic inflammatory skin disease that may adversely impact kidney function in affected individuals. This study aimed to investigate estimated glomerular filtration rate (eGFR) hospitalized patients with psoriasis, analyze its influencing factors, and explore the effects of sex age on eGFR psoriasis. Methods retrospectively analyzed values 456 psoriasis who were admitted two hospitals Taizhou, Zhejiang Province from January 2012 December 2023 using multiple linear regression. Results The prevalence (CKD) among was 7.9% (36/456). Multiple regression analysis revealed (B = -5.50, P 0.014), -23.10, < 0.001), duration -4.36, 0.018), hypertension -9.41, cardiovascular -8.68, 0.019), gout -18.73, 0.001) as main factors Subgroup by -22.32, -4.95, 0.021), -10.65, -17.56, male whereas -24.75, -32.83, 0.002), -44.00, 0.015) female -6.63, 0.015), -6.51, 0.006), -10.90, -14.84, 0.011) aged 60 years, -8.08, 0.008), -11.21, 0.020), -26.41, 0.005) ≥ years. Conclusion research indicated that differences sex. Hence, corresponding measures should be formulated for different ages sexes clinical settings.

Язык: Английский

---

Bidirectional predictors between baseline and recovery sleep measures and cardiovascular measures during sleep deprivation and psychological stress

Physiological Reports, Год журнала: 2025, Номер 13(10)

Опубликована: Май 1, 2025

Abstract For the first time, we investigated bidirectional predictors between baseline and recovery sleep cardiovascular (CV) measures during total deprivation (TSD) psychological stress in a five‐day experiment with 32 healthy adults (27‐53y; 14 females). CV were collected morning after two nights (B1, B2) TSD (TSD AM) evening following PM). Actigraphy assessed B2 before night (R1) TSD. Higher wake onset (WASO) predicted lower PM stroke volume higher systemic vascular resistance index (SVRI), greater percent predicting inverse relationships, explaining 12.8%–15.9% of variance. Also, WASO AM SVRI. Furthermore, longer left ventricular ejection time later R1 offset, duration, WASO; by contrast, heart rate earlier offset. indices explained 14.8%–24.9% Notably, females showed significant predictive relationships. Our novel results demonstrate that predicts metrics stress, these predict sleep, underscoring crucial mechanisms, biomarkers health.

Язык: Английский

---

Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture

Hypertension, Год журнала: 2024, Номер 81(6), С. 1233 - 1243

Опубликована: Март 27, 2024

The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development multicellular organisms. This evolutionary process is essential for coordination maintenance homeostasis overall health by facilitating adaptation organism to internal external cues. Disruption these complex interactions contributes progression pathologies involve multiple organs. Obesity-associated risks, such as hypertension, highlight significant influence processes exert on system. cardiometabolic communication reciprocal, indicated substantial evidence pointing ability system affect processes, with pathophysiological implications in disease conditions. In this review, I outline bidirectional nature interaction, special emphasis impact organs have also discuss contribution neural circuits autonomic nervous mediating crosstalk between functions disease, along molecular mechanisms involved.

Язык: Английский

---