Systemic Mechanisms of Ionic Regulation in Carcinogenesis

Cancers, Год журнала: 2025, Номер 17(2), С. 286 - 286

Опубликована: Янв. 17, 2025

Cancer is a complex disease characterized by uncontrolled cell proliferation at various levels, leading to tumor growth and spread. This review focuses on the role of ion homeostasis in cancer progression. It describes model ion-mediated regulation both normal cancerous proliferation. The main function this system maintain optimal number cells body regulating intra- extracellular content. discusses key points their impact spread during development. explains that levels sodium, potassium, calcium, chloride, hydrogen ions are regulated different levels. Damage transport mechanisms carcinogenesis can lead an increase sodium cations water content cells, disrupting balance calcium ions. This, turn, chromatin compaction reduction, gene overexpression, instability epigenetic genomic resulting increased mutagenesis. Restoring reduce proliferative potential populations. proposed systemic ionic aims reconcile diverse data related mitotic activity physiological conditions explain growth. Understanding behind pathological important for developing new approaches control body, potentially more effective treatment prevention.

Язык: Английский

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Simulated Heat Waves Affect Cell Fate and Fitness in the Social Amoeba Dictyostelium discoideum

Microbial Ecology, Год журнала: 2025, Номер 88(1)

Опубликована: Апрель 1, 2025

Язык: Английский

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Enhancing terpenoid production in Saccharomyces cerevisiae via cell morphology engineering

Biotechnology Letters, Год журнала: 2025, Номер 47(3)

Опубликована: Май 17, 2025

Язык: Английский

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A Generalized Adder mechanism for Cell Size Homeostasis: Implications for Stochastic Dynamics of Clonal Proliferation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Abstract Measurements of cell size dynamics have revealed phenomeno-logical principles by which individual cells control their across diverse organisms. One the emerging paradigms homeostasis is adder , where cycle duration established such that increase from birth to division independent newborn size. We provide a mechanistic formulation considering follows any arbitrary non-exponential growth law . Our results show main requirement obtain an regardless (the time derivative size) regulators are produced at rate proportional and triggered when these molecules reach prescribed threshold level. Among implications this generalized adder, we investigate fluctuations in proliferation single-cell derived colonies. Considering exponential growth, random clonal transient then eventually decay zero over (i.e., populations become asymptotically more similar). In contrast, several forms (with adder-based control) yield qualitatively different results: monotonically reaching non-zero value. These characterize interplay between level population level, explaining broad sizes seen barcoded human lines.

Язык: Английский

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Single-cell imaging reveals a key role of Bck2 in budding yeast cell size adaptation to nutrient challenges

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Abstract Cell size is tightly controlled to optimize cell function and varies broadly depending on the organism, type, environment. The budding yeast S. cerevisiae has been successfully used as a model gain insights into eukaryotic control. Multiple regulators of in steady-state conditions have identified, such G1/S transition activators Cln3 Bck2 inhibitor Whi5. Individual deletions these result populations with altered mean volumes. However, homeostasis remains largely intact. Here, we show that although roles for regulation appear redundant steady-state, switch from fermentable non-fermentable growth media reveals unique role adaptation changing nutrients. We use live-cell microscopy machine learning-assisted image analysis track single cells their progeny through nutrient switch. find after switch, bck2Δ experience longer cycle arrests more arrest-associated enlargement than wild-type, whi5Δ or cln3Δ cells, indicating becomes critical activator Our work demonstrates studying during shifts mimic dynamic environments free-growing microorganisms can resolve apparent redundancies observed regulation.

Язык: Английский

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Cell biology: Wanderers that balloon towards light

Current Biology, Год журнала: 2024, Номер 34(22), С. R1139 - R1141

Опубликована: Ноя. 1, 2024

Язык: Английский

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