Frontiers in Physiology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 13, 2022
Most
hypertensive
cases
are
primary
and
heavily
associated
with
modifiable
risk
factors
like
salt
intake.
Evidence
suggests
that
even
small
reductions
in
consumption
reduce
blood
pressure
all
age
groups.
In
regard,
the
ACC/AHA
described
a
distinct
set
of
individuals
who
exhibit
salt-sensitivity,
regardless
their
status.
Data
has
shown
salt-sensitivity
is
an
independent
factor
for
cardiovascular
events
mortality.
However,
despite
extensive
research,
pathogenesis
salt-sensitive
hypertension
still
unclear
tremendously
challenged
by
its
multifactorial
etiology,
complicated
genetic
influences,
unavailability
diagnostic
tool.
So
far,
important
roles
renin-angiotensin-aldosterone
system,
sympathetic
nervous
immune
system
have
been
studied.
first
part
this
review,
we
focus
on
how
systems
mentioned
above
aberrantly
regulated
hypertension.
We
follow
emphasis
variants
those
and/or
increase
predisposition
to
humans.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(6), С. 2224 - 2254
Опубликована: Янв. 1, 2022
This
review
summarizes
angstrom-scale
ion
channels
with
0D–3D
pore
structures
and
their
charge,
mono/divalent,
single-ion
selectivities
potential
applications.
Traffic,
Год журнала:
2019,
Номер
21(1), С. 76 - 93
Опубликована: Ноя. 5, 2019
The
late
endosomes/endo-lysosomes
of
vertebrates
contain
an
atypical
phospholipid,
lysobisphosphatidic
acid
(LBPA)
(also
termed
bis[monoacylglycero]phosphate
[BMP]),
which
is
not
detected
elsewhere
in
the
cell.
LBPA
abundant
membrane
system
present
lumen
this
compartment,
including
intralumenal
vesicles
(ILVs).
In
review,
current
knowledge
on
and
LBPA-containing
membranes
will
be
summarized,
their
role
control
endosomal
cholesterol
outlined.
Some
speculations
also
made
how
may
overwhelmed
storage
disorder
Niemann-Pick
C.
Then,
roles
endo-lysosomal
dynamics
functions
discussed
broader
terms.
Likewise,
mechanisms
that
drive
biogenesis
membranes,
ESCRTs,
discussed,
as
well
diverse
composition
fate,
degradation
lysosomes
secretion
exosomes.
This
review
discuss
are
hijacked
by
pathogenic
agents
during
intoxication
infection,
what
biochemical
function
intra-endosomal
lumenal
milieu.
Finally,
allude
to
size
limitations
imposed
vesicle
speculate
possible
calcium
chelator
acidic
stores
endo-lysosomes.
Physiological Reviews,
Год журнала:
2019,
Номер
99(4), С. 2015 - 2113
Опубликована: Сен. 11, 2019
Na+/H+
exchangers
play
pivotal
roles
in
the
control
of
cell
and
tissue
pH
by
mediating
electroneutral
exchange
Na+
H+
across
cellular
membranes.
They
belong
to
an
ancient
family
highly
evolutionarily
conserved
proteins,
they
essential
physiological
all
phyla.
In
this
review,
we
focus
on
mammalian
(NHEs),
solute
carrier
(SLC)
9
family.
This
transporters
constitutes
three
branches:
SLC9A,
-B,
-C.
Within
these,
each
isoform
exhibits
distinct
expression
profiles,
regulation,
roles.
Some
these
are
studied,
with
hundreds
original
articles,
some
still
only
rudimentarily
understood.
present
discuss
pioneering
work
as
well
current
state-of-the-art
research
NHEs.
We
aim
provide
reader
a
comprehensive
view
core
knowledge
recent
insights
into
member,
from
gene
organization
over
protein
structure
regulation
pathophysiological
Particular
attention
is
given
integrated
physiology
NHEs
main
organ
systems.
several
novel
analyses
useful
overviews,
pinpoint
remaining
enigmas,
which
hope
will
inspire
versatile
proteins.
Physiological Reviews,
Год журнала:
2022,
Номер
103(1), С. 433 - 513
Опубликована: Авг. 11, 2022
Developmental
and
epileptic
encephalopathies
(DEEs)
are
a
heterogeneous
group
of
disorders
characterized
by
early-onset,
often
severe
seizures
EEG
abnormalities
on
background
developmental
impairment
that
tends
to
worsen
as
consequence
epilepsy.
DEEs
may
result
from
both
nongenetic
genetic
etiologies.
Genetic
have
been
associated
with
mutations
in
many
genes
involved
different
functions
including
cell
migration,
proliferation,
organization,
neuronal
excitability,
synapse
transmission
plasticity.
Functional
studies
performed
animal
models
clinical
trials
patients
contributed
elucidate
pathophysiological
mechanisms
underlying
explored
the
efficacy
treatments.
Here,
we
provide
an
extensive
review
phenotypic
spectrum
included
determinants
these
conditions.
We
also
brief
overview
most
effective
treatment
now
available
emerging
therapeutic
approaches.
Frontiers in Physiology,
Год журнала:
2020,
Номер
11
Опубликована: Фев. 14, 2020
Ion
channels
are
integral
membrane
proteins
present
on
the
plasma
as
well
intracellular
membranes.
It
had
been
long
thought
that
transmembrane
ion
fluxes
depend
conduction
pathways
located
within
a
specific
group
of
given
lipid
bilayer
was
characterized
impermeable
to
water-soluble
ions.
Only
in
1980s,
convergence
state-of-the-art
biophysical
and
molecular
biological
techniques
allowed
in-depth
characterization
identification
responsible
for
fluxes.
In
human
genome,
there
more
than
400
known
genes
encoding
channels.
On
changing
their
conformation
from
closed
open
states,
they
allow
ions
flow
through
them
albeit
tightly
regulating
ionic
flux.
regulate
several
cellular,
organellar
physiological
processes,
any
mutation
or
disruption
function
can
result
common
(tumors)
rare
pathological
disorders.
widely
acknowledged
role
various
processes
but
recent
years,
studies
have
pointed
out
importance
Intracellular
not
well-understood
context
conditions
such
oncochannelopathies
therapeutic
targets
cancer.
A
novel
class
channels,
Chloride
Channels
(CLICs),
mainly
documented
cardiovascular
neurophysiology,
tumor
biology.
They
recently
shown
be
localized
mitochondria.
fact,
CLIC5
is
first
mitochondrial
chloride
channel
identified
up
level
inner
membrane,
CLIC4
predominantly
outer
this
review,
we
focused
unique
pathologies
include
cardiovascular,
cancer
neurodegenerative
diseases.
