Lymphatic Research and Biology, Год журнала: 2023, Номер 21(2), С. 194 - 226
Опубликована: Апрель 1, 2023
Circulation Research, Год журнала: 2023, Номер 132(9), С. 1185 - 1202
Опубликована: Апрель 27, 2023
Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a variety cardiovascular-related pathophysiologies. Thus, there is strong supporting evidence encouraging exploration AM-CLR (calcitonin receptor-like receptor) signaling pathway therapeutic target. This further bolstered because several drugs targeting shared CGRP gene-related peptide)-CLR are already Food Drug Administration-approved on market treatment migraine. In this review, we summarize its modulatory mechanisms provide overview current understanding physiological pathological roles yet untapped potentials target in cardiac vascular diseases outlook recently emerged strategies that may boost to possible applications signaling.
Язык: Английский
Процитировано
21
Journal of Clinical Investigation, Год журнала: 2023, Номер 133(17)
Опубликована: Авг. 31, 2023
The lymphatic system (LS) is composed of lymphoid organs and a network vessels that transport interstitial fluid, antigens, lipids, cholesterol, immune cells, other materials in the body. Abnormal development or malfunction LS has been shown to play key role pathophysiology many disease states. Thus, improved understanding anatomical molecular characteristics may provide approaches for prevention treatment. Recent advances harnessing single-cell technologies, clinical imaging, discovery biomarkers, computational tools have led strategies study LS. This Review summarizes outcomes NIH workshop entitled "Yet be Charted: Lymphatic System Health Disease," held September 2022, with emphasis on major areas advancement. International experts showcased current state knowledge regarding highlighted remaining challenges opportunities advance field.
Язык: Английский
Процитировано
21
Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2024, Номер 44(5), С. 1016 - 1020
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
7
Nature Cardiovascular Research, Год журнала: 2024, Номер 3(5), С. 515 - 524
Опубликована: Май 14, 2024
Язык: Английский
Процитировано
7
Hypertension, Год журнала: 2024, Номер 81(4), С. 727 - 737
Опубликована: Фев. 22, 2024
Blood pressure is regulated by vascular resistance and intravascular volume. However, exchanges of electrolytes water between intra extracellular spaces filtration fluid solutes in the capillary beds blur separation intravascular, interstitial intracellular compartments. Contemporary paradigms microvascular exchange posit fluids along whole bed a prominent role lymphatic vessels, rather than its venous end, for their reabsorption. In last decade, these concepts have stimulated greater interest better understanding system as one master regulators volume homeostasis. Here, we describe anatomy function focus on plasticity relation to accumulation sodium hypertension. The pathophysiological relevance exemplified kidneys, which are crucially involved control blood pressure, but also hypertension-mediated cardiac damage. Preclinical modulation reserve tissue drainage has demonstrated promise, generated conflicting results. A hydraulic element hypertension lymphatics maintaining balance can open new approaches prevent treat consequences, such heart failure.
Язык: Английский
Процитировано
6
Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2024, Номер 44(6), С. 1181 - 1190
Опубликована: Апрель 18, 2024
Cardiovascular diseases remain the largest cause of death worldwide with recent evidence increasingly attributing development and progression these to an exacerbated inflammatory response. As a result, significant research is now focused on modifying immune environment prevent disease progression. This in turn has highlighted lymphatic system pathophysiology cardiovascular owing, part, its established function cell surveillance trafficking. In this review, we highlight role cardiac potential as immunomodulatory therapeutic target selected diseases.
Язык: Английский
Процитировано
6
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
6
Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102542 - 102542
Опубликована: Окт. 12, 2024
Язык: Английский
Процитировано
5
Biology, Год журнала: 2023, Номер 12(7), С. 1039 - 1039
Опубликована: Июль 23, 2023
Lymphatic vessels are capable of sustaining lymph formation and propulsion via an intrinsic mechanism based on the spontaneous contraction lymphatic muscle in wall collectors. Exposure to a hyper- or hypo-osmolar environment can deeply affect rate therefore alter flow. In this work, we aimed at defining putative receptors underlying such response. Functional experiments were conducted ex vivo rat diaphragmatic specimens containing spontaneously contracting that exposed either solutions. Lymphatics challenged with blockers TRPV4, TRPV1, VRAC channels, known respond changes osmolarity and/or cell swelling expressed by vessels. Results show normal response hyperosmolar is steady decrease flow be prevented blocking TRPV1 channels capsazepine. The hyposmolar consists early phase increase rate, followed decrease. abolished VRACs DCPIB, while TRPV4 mainly resulted delay Overall, our data suggest cooperation three shape terms frequency flow, prominent role VRACs.
Язык: Английский
Процитировано
6
International Journal of Molecular Medicine, Год журнала: 2024, Номер 53(4)
Опубликована: Фев. 22, 2024
Heart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays crucial role in regulating essential physiological processes, including fluid balance, transportation extravasated proteins immune cell trafficking, all which are important for heart function. Through thorough scientometric analysis extensive research, present review identified lymphangiogenesis as hotspot mechanisms underlying impaired cardiac inadequate lymph drainage various diseases discussed. Furthermore, way used improve effectively regulate variety associated signaling pathways was investigated. Notably, current also highlights impact Traditional Chinese Medicine (TCM) on lymphangiogenesis, aiming establish clinical basis potential TCM by promoting lymphangiogenesis.
Язык: Английский
Процитировано
2