Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

Journal of the Science of Food and Agriculture, Год журнала: 2021, Номер 101(14), С. 5747 - 5762

Опубликована: Июнь 18, 2021

Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as an aromatic stimulant, food preservative, coloring material. The commonly used names of turmeric are castor saffron, turmeric, saffron root. yellow-orange polyphenolic natural substance derived from C. rhizomes. It has been to treat common inflammatory diseases, tumors, biliary anorexia, cough, topical wounds, diabetic injuries, liver disorders, rheumatism, sinusitis. Extensive studies on the biological properties pharmacological consequences extracts have conducted recent years. Curcumin, primary yellow biocomponent anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic, antibacterial, antiprotozoal, antiviral, antifibrotic, immunomodulatory, antifungal properties. Defense assessment tests showed that curcumin tolerated well at high doses, without adverse effects. Thus, highly active material with potential different diseases modern medicine. This review article focuses curcumin's characteristics. most popular methods for encapsulation also discussed. Several effective techniques approaches proposed curcuminoid capsulation, including nanocomplexing, gelation, complex coacervation, electrospraying, solvent-free pH-driven encapsulation. highlights chemical properties, allowing readers expand their perspectives its use development functional products health-promoting © 2021 Society Chemical Industry.

Язык: Английский

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Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

European Journal of Medicinal Chemistry, Год журнала: 2015, Номер 103, С. 133 - 162

Опубликована: Авг. 28, 2015

Язык: Английский

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Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

Pharmaceuticals, Год журнала: 2021, Номер 14(8), С. 806 - 806

Опубликована: Авг. 17, 2021

Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by chronic hyperglycaemia, insulin resistance, and inefficient secretion action. Primary care in T2DM pharmacological, using drugs several groups that include sensitisers (e.g., biguanides, thiazolidinediones), secretagogues sulphonylureas, meglinides), alpha-glucosidase inhibitors, newest incretin-based therapies sodium-glucose co-transporter inhibitors. However, their long-term application can cause many harmful side effects, emphasising importance natural therapeutic products. Natural health substances including non-flavonoid polyphenols resveratrol, curcumin, tannins, lignans), flavonoids anthocyanins, epigallocatechin gallate, quercetin, naringin, rutin, kaempferol), plant fruits, vegetables other products garlic, green tea, blackcurrant, rowanberry, bilberry, strawberry, cornelian cherry, olive oil, sesame carrot) may be a safer alternative to primary pharmacological therapy. They are recommended as food supplements prevent and/or ameliorate T2DM-related complications. In advanced stage T2DM, combination therapy synthetic agents compounds with synergistic interactions makes treatment more efficient. this review, both pharmaceutical selected products, well therapies, characterized. Mechanisms action possible negative effects also provided.

Язык: Английский

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Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial

European Journal of Nutrition, Год журнала: 2019, Номер 59(2), С. 477 - 483

Опубликована: Фев. 22, 2019

Curcumin has shown to exert a positive impact on human glucose metabolism, even if its bioavailability is usually very low. The present study aimed explore the effect of phosphatidylserine- and piperine-containing curcumin phytosomes large number metabolic parameters related insulin resistance, in context randomized double-blind placebo-controlled trial involving 80 overweight subjects with suboptimal fasting plasma glucose. Subjects were be treated indistinguishable tablets (2 per day, taken after dinner) containing 800 mg phytosomal (Curserin®: 200 curcumin, 120 phosphatidylserine, 480 phosphatidylcholine 8 piperine from Piper nigrum L. dry extract) for weeks. After 56-day treatment, curcumin-treated group experienced significant improvement (FPI), HOMA index, waist circumference, blood pressure, triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index steatosis serum cortisol compared baseline. FPI, TG, fatty level also significantly improved placebo-treated group. Compared baseline, at end placebo an only FPG TG. In conclusion, shows that supplementation preparation phosphatidylserine could improve glycemic factors, hepatic function levels impaired

Язык: Английский

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Antidiabetic phytoconstituents and their mode of action on metabolic pathways

Therapeutic Advances in Endocrinology and Metabolism, Год журнала: 2018, Номер 9(3), С. 81 - 100

Опубликована: Фев. 12, 2018

Diabetes Mellitus, characterized by persistent hyperglycaemia, is a heterogeneous group of disorders multiple aetiologies. It affects the human body at organ levels thus making it difficult to follow particular line treatment protocol and requires multimodal approach. The increasing medical burden on patients with diabetes-related complications results in an enormous economic burden, which could severely impair global growth near future. This shows that today’s healthcare system has conventionally been poorly equipped towards confronting mounting impact diabetes scale demands urgent need for newer better options. overall challenge this field identify individualized factors can lead improved glycaemic control. Plants are traditionally used worldwide as remedies healing. They synthesize diverse array biologically active compounds having antidiabetic properties. review endeavour document present armamentarium herbal drug discovery developments, highlighting mechanism-based properties over 300 different phytoconstituents various chemical categories from about 100 plants modulating metabolic pathways such glycolysis, Krebs cycle, gluconeogenesis, glycogen synthesis degradation, cholesterol synthesis, carbohydrate metabolism well peroxisome proliferator activated receptor activation, dipeptidyl peptidase inhibition free radical scavenging action. aim provide rich reservoir pharmacologically established specific references novel, cost-effective interventions, might be relevance other low-income middle-income countries world.

Язык: Английский

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Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial

Nutrition & Metabolism, Год журнала: 2019, Номер 16(1)

Опубликована: Янв. 28, 2019

Since lifestyle changes are main therapies for non-alcoholic fatty liver disease (NAFLD), changing dietary components (nutritional or bioactive) may play a parallel important role. Few studies have assessed the effects of curcumin on NAFLD (mainly antioxidant and anti-inflammatory effects). We aimed to determine nano-curcumin (NC) overweight/obese patients by assessing glucose, lipids, inflammation, insulin resistance, function indices, especially through nesfatin. This double-blind, randomized, placebo-controlled clinical trial was conducted in Oil Company Central Hospital, Tehran. 84 with diagnosed using ultrasonography were recruited according eligibility criteria (age 25-50 yrs., body mass index [BMI] 25-35 kg/m2). The randomly divided into two equal NC (n = 42) placebo groups. Interventions 40 mg capsules/day after meals 3 months. Lifestyle advised. A general questionnaire, 24-h food recall (at beginning, middle end), short-form international physical activity questionnaire beginning end) completed. Also, blood pressure, degree, anthropometrics, fasting sugar (FBS) (FBI), glycated hemoglobin (HbA1c), homeostasis model assessment-insulin resistance (HOMA-IR), quantitative sensitivity check (QUICKI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-c), high-density (HDL-c), tumor necrosis factor-alpha (TNF-α), high sensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), transaminases, nesfatin determined at end. compared significantly increased HDL, QUICKI, decreased waist circumference (WC), FBS, FBI, HbA1c, TG, TC, LDL, HOMA-IR, TNF-α, hs-CRP, IL-6 (P < 0.05). mean weight, BMI, composition (BC), pressure not significant > After adjustment confounders, similar unadjusted model. supplementation improved glucose WC, nesfatin, degree. Accordingly, proposed mechanism ameliorating approved serum likely consequent improvements profile. Further trials nano-curcumin's suggested. Iranian Registry Clinical Trials, IRCT2016071915536N3. Registered 2016-08-02.

Язык: Английский

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The effects of curcumin supplementation on high‐sensitivity C‐reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial

Phytotherapy Research, Год журнала: 2019, Номер 33(5), С. 1374 - 1383

Опубликована: Март 12, 2019

Diabetes mellitus is one of the most common and important metabolic diseases in human. Curcumin, which a natural polyphenol found turmeric, can be used treatment diabetes complications for its antidiabetic, anti‐inflammatory, antioxidant properties. In this double‐blind randomized clinical trial, 44 patients with Type 2 randomly assigned to curcumin or placebo group. Patients consumed either 1,500‐mg daily 10 weeks. Anthropometric measurements were measured at baseline end study. Serum concentrations triglyceride (TG), total cholesterol, high‐density lipoprotein low‐density high‐sensitivity C‐reactive protein, adiponectin determined after 12‐hr fasting beginning The mean serum level TG decreased group compared (109 ± 36 vs. 124 36; p < 0.05). At study, concentration protein control (2.9 2.9 3.4 4.2; increased (64 3 63 4; 0.05) results current study indicate that consumption may reduce through decreasing as well indicators inflammation.

Язык: Английский

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Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial

Frontiers in Pharmacology, Год журнала: 2021, Номер 12

Опубликована: Май 28, 2021

Background: Coronavirus disease-2019 (COVID-19) has a wide range of pathophysiological effects. Curcumin, an active constituent Curcuma longa (turmeric), several properties, including anti-inflammatory, antioxidant, antiviral, anti-thrombotic, and anti-proliferative effects, which make it promising candidate for the symptomatic treatment COVID-19. Objective: We aimed to determine effects curcumin administered with piperine (to optimize absorption) on symptoms in patients COVID-19 double-blind, randomized, controlled trial at 30-bed dedicated COVID Health Center (DCHC) Maharashtra, India. Methods: In addition conventional treatment, control group received dose probiotics twice day, study (525 mg) (2.5 tablet form day. The curcumin/piperine primary secondary outcomes were assessed duration hospitalization. Results: Patients mild, moderate, severe who showed early recovery (fever, cough, sore throat, breathlessness), less deterioration, fewer red flag signs, better ability maintain oxygen saturation above 94% room air, clinical compared group. Furthermore, appeared reduce hospitalization moderate symptoms, deaths observed Conclusions: Administration oral as adjuvant therapy could substantially morbidity mortality, ease logistical supply-related burdens healthcare system. Curcumin be safe natural therapeutic option prevent Post-Covid thromboembolic events. Clinicaltrials.gov identifier: CTRI/2020/05/025482

Язык: Английский

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Wound-Healing Effects of Curcumin and Its Nanoformulations: A Comprehensive Review

Pharmaceutics, Год журнала: 2022, Номер 14(11), С. 2288 - 2288

Опубликована: Окт. 25, 2022

Wound healing is an intricate process of tissue repair or remodeling that occurs in response to injury. Plants and plant-derived bioactive constituents are well explored the treatment various types wounds. Curcumin a natural polyphenolic substance has been used since ancient times Ayurveda for its properties, as it reduces inflammation acts on several stages. Several research studies curcumin delivery at wound site reported effectiveness eradicating reactive oxygen species ability enhance deposition collagen, granulation formation, finally, expedite contraction. widely investigated potential but lower solubility rapid metabolism, addition shorter plasma half-life, have limited applications healing. As nanotechnology proven be effective technique accelerate by stimulating appropriate mobility through phases, curcumin-loaded nanocarriers targeted sites. This review highlights nanoformulations, such liposomes, nanoparticles, nano-emulsions, etc. paper emphasizes numerous biomedical which collectively prepare base antibiofilm wound-healing action.

Язык: Английский

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Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity

BMC Endocrine Disorders, Год журнала: 2023, Номер 23(1)

Опубликована: Янв. 16, 2023

Polycystic ovary syndrome (PCOS) is a common condition affecting reproductive-aged women with reproductive, metabolic and psychological consequences. Weight lifestyle (diet, physical activity behavioural) management are first-line therapy in international evidence-based guidelines for PCOS. While these recommend following population-level diet guidelines, there ongoing interest research the potential benefit of including sleep interventions, as well range traditional, complimentary integrative medicine (TCIM) approaches, optimal There limited evidence to specific composition PCOS approaches modifying protein, carbohydrate or fat quality quantity generally having similar effects on presentations With regards activity, promising supports provision vigorous aerobic exercise, which has been shown improve body composition, cardiorespiratory fitness insulin resistance. Psychological interventions also important considerations, displaying poor emotional wellbeing higher rates clinical subclinical disturbance, potentially limiting their ability make positive change. optimising may aid symptom PCOS, exploring efficacy lacking. Uptake TCIM particular supplement herbal use, by growing. However, currently insufficient support integration into routine practice. Research investigating inositol supplementation have produced most findings, showing improved profiles reduced hyperandrogenism. Findings other supplements, medicines, acupuncture yoga so far inconsistent, reduce heterogeneity more populations, (e.g. defined age BMI ranges) consistent intervention delivery, duration comparators needed. components addition population-recommendations robust trials warranted expand relatively evidence-base regarding holistic management. consumer healthcare rising, providers will be required broaden knowledge pertaining how therapies can safely appropriately utilised adjuncts conventional medical

Язык: Английский

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