Metabolites,
Год журнала:
2023,
Номер
13(5), С. 655 - 655
Опубликована: Май 13, 2023
The
elderly
have
higher
concentrations
of
advanced
glycation
end-products
(AGEs).
AGEs
are
considered
risk
factors
that
accelerate
aging
and
cause
diabetic
nephropathy.
effects
on
renal
function
in
the
remain
to
be
clarified.
This
study
aimed
explore
role
decline
protective
effect
resveratrol,
a
stilbenoid
polyphenol,
comparing
it
with
aminoguanidine
(an
inhibitor).
A
D-galactose-induced
mouse
model
was
used
process
aging.
mice
were
administered
D-galactose
subcutaneously
for
eight
weeks
presence
or
absence
orally
resveratrol.
results
showed
serum
levels
markers
BUN,
creatinine,
cystatin
C
significantly
increased
after
administration
D-galactose,
this
outcome
could
reversed
by
treatment
protein
expression
apoptosis,
fibrosis,
aging-related
indicators
kidneys
increased,
which
also
These
findings
suggest
resveratrol
alleviate
AGEs-related
dysfunction
through
improvement
cellular
senescence,
fibrosis
mice.
Objective:
The
objective
of
this
study
was
to
detect
the
prevalence
incidental
chronic
kidney
disease
(CKD)
in
patients
newly
diagnosed
with
type
2
diabetes
(T2D).
Method:
This
a
cross-sectional
conducted
from
July
2023
November
2024,
at
Faiha
Specialized
Diabetes,
Endocrine,
and
Metabolism
Center
Al-Rafidain
Basrah,
southern
Iraq.
A
total
202
drug-naïve
T2D
were
included.
baseline
clinical
biochemical
characteristics
for
inclusion.
CKD
by
measuring
estimated
glomerular
filtration
rate
(eGFR)
urine
albumin
creatinine
ratio
(UACR).
Results:
mean
age
included
49.1±12
years.
68
(33.7%)
based
on
GFR
<60
mL/minute/1.73
m2
and/or
UACR
≥
30
mg/g.
categories
G1,
2,
G3a,
3b
prevalent
71.3%,
24.2%,
3.0%,
1.5%,
respectively.
For
albuminuria,
31.2%
had
10-30
mg/g,
22.8%
30-300
7.9%
higher
than
300
stepwise
binary
regression
analysis
showed
that
patients'
HbA1c
levels
factors
significantly
associated
CKD.
Conclusion:
is
one-third
T2D.
Early
screening
highly
recommended
as
it
will
affect
overall
management.
Metabolites,
Год журнала:
2023,
Номер
13(5), С. 655 - 655
Опубликована: Май 13, 2023
The
elderly
have
higher
concentrations
of
advanced
glycation
end-products
(AGEs).
AGEs
are
considered
risk
factors
that
accelerate
aging
and
cause
diabetic
nephropathy.
effects
on
renal
function
in
the
remain
to
be
clarified.
This
study
aimed
explore
role
decline
protective
effect
resveratrol,
a
stilbenoid
polyphenol,
comparing
it
with
aminoguanidine
(an
inhibitor).
A
D-galactose-induced
mouse
model
was
used
process
aging.
mice
were
administered
D-galactose
subcutaneously
for
eight
weeks
presence
or
absence
orally
resveratrol.
results
showed
serum
levels
markers
BUN,
creatinine,
cystatin
C
significantly
increased
after
administration
D-galactose,
this
outcome
could
reversed
by
treatment
protein
expression
apoptosis,
fibrosis,
aging-related
indicators
kidneys
increased,
which
also
These
findings
suggest
resveratrol
alleviate
AGEs-related
dysfunction
through
improvement
cellular
senescence,
fibrosis
mice.
