Molecular mechanisms of oxidative stress in stroke and cancer

Brain Disorders, Год журнала: 2021, Номер 5, С. 100029 - 100029

Опубликована: Дек. 18, 2021

Oxidative stress is a silent participant in all chronic progressive pathology and degenerative disorders. Neurodegeneration cognitive impairment are caused by increased imbalanced oxidative down-regulated natural anti-oxidant combat mechanisms. Cancer the end result of cell malfunction activation tumour-specific genes, which regulated specific geneomolecular pathways. Acute stroke decrease body's combating defence stress, results from an imbalance between antioxidative activities cells, has been linked to aetiology number diseases, including cancer stroke. The harmful effects ROS their role lesion progression after ischaemic undeniable; however, therapeutic usefulness anti-oxidants this scenario remains debatable. In review, we have summarised potent molecular mechanisms play vital through various pathways associated advanced targeted therapeutics like pathologies.

Язык: Английский

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Potential health benefits of anthocyanins in oxidative stress related disorders

Phytochemistry Reviews, Год журнала: 2021, Номер 20(4), С. 705 - 749

Опубликована: Май 8, 2021

Язык: Английский

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A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Июнь 13, 2022

Aging is a normal, inevitable, irreversible, and progressive process which driven by internal external factors. Oxidative stress, that the imbalance between prooxidant antioxidant molecules favoring first, plays key role in pathophysiology of aging comprises one molecular mechanisms underlying age-related diseases. However, oxidative stress theory has not been successfully proven all animal models studying lifespan, meaning altering stress/antioxidant defense systems did always lead to prolonged as expected. On other hand, pathological phenotypes showed well-correlated relationship with levels molecules. Therefore, it seems more complicated than once believed this might be affected environment each organism. Environmental factors such UV radiation, air pollution, an unbalanced diet, have also implicated seem initiate rapidly even at younger ages.The purpose review elucidate physiology effect certain environmental initiating sustaining process. Understanding will contribute development strategies postpone phenomenon. In addition, recent studies investigating ways alter order prevent presented.Careful exposure harmful use supplements could potentially affect biological processes driving slow down Maybe lifespan achieved strategy alone, but longer healthspan favorable target.

Язык: Английский

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Psoriasis between Autoimmunity and Oxidative Stress: Changes Induced by Different Therapeutic Approaches

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 17

Опубликована: Март 12, 2022

Psoriasis is defined as chronic, immune-mediated disease. Regardless of the development new therapeutic approaches, precise etiology psoriasis remains unknown and speculative. The aim this review was to systematize results previous research on role oxidative stress aberrant immune response in pathogenesis psoriasis, well impact certain modalities status patients with psoriasis. Complex pathways both innate adaptive systems appear be major pathomechanisms Oxidative represents another important contributor pathophysiology disease, redox imbalance has been reported skin cells and, systemically, plasma blood cells, more recently, also saliva. Current model begins activation system susceptible person by some environmental factor loss tolerance autoantigens. Increased production IL-17 appears most prominent pathogenesis, while IL-23 recognized master regulator having a specific cross bridging acquired immunity. Other proinflammatory cytokines, including IFN-γ, TNF-α, IL-1β, IL-6, IL-22, IL-26, IL-29, or IL-36, have play roles can promote inflammation through several signaling pathways. noticeable powerful antioxidative effects exert various biologics compared convenient modalities, such methotrexate phototherapy. complex interaction redox, immune, inflammatory should focused further researches tackling supplementation could solution refractory cases

Язык: Английский

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Dietary nutrients in edible mushroom, Agaricus bisporus and their radical scavenging, antibacterial, and antifungal effects

Process Biochemistry, Год журнала: 2022, Номер 121, С. 10 - 17

Опубликована: Июнь 23, 2022

Язык: Английский

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The Effect of β-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used

Biomolecules, Год журнала: 2022, Номер 12(8), С. 1087 - 1087

Опубликована: Авг. 7, 2022

Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and functioning, is associated with the development of numerous disorders. Naturally occurred anti-oxidant compounds reduce in living organisms. In this review, antioxidant properties β-carotene, tocopherols ascorbic acid are presented based vitro, vivo populational studies. Firstly, environmental factors contributing to OS occurrence intracellular sources Reactive Oxygen Species (ROS) generation, as well ROS-mediated cellular degradation, introduced. Secondly, enzymatic non-enzymatic mechanism defence against development, presented. Furthermore, ROS-preventing mechanisms effectiveness anti-oxidants summarized, studies where different ROS-generating (oxidizing) agents used. Oxidative biomarkers, indicators level prevention by supplementation, a focus methods (spectrophotometric, fluorometric, chromatographic, immuno-enzymatic) their detection. Finally, application Raman spectroscopy imaging tool for monitoring (β-carotene, acid) metabolism, proposed. Literature data gathered suggest that possess potential mitigate various biological systems. Moreover, can be valuable technique study molecules

Язык: Английский

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Comprehensive Analysis of Bioactive Compounds in Wild Ganoderma applanatum Mushroom from Kerala, South India: Insights into Dietary Nutritional, Mineral, Antimicrobial, and Antioxidant Activities

Pharmaceuticals, Год журнала: 2024, Номер 17(4), С. 509 - 509

Опубликована: Апрель 17, 2024

The present study focused on the mushroom Ganoderma, which has been used in Eastern countries for centuries as a food and medicinal source. Specifically, fruiting bodies of Ganoderma applanatum from Kerala Forest Research Institute Thirussur, Kerala, India, were analyzed their nutritional properties. methanolic extracts G. to examine secondary metabolites proximate profiles, revealing presence various phytochemicals such terpenoids, phenolics, glycosides, alkaloids, flavonoids, saponins. Further analysis revealed significant amounts calcium, sodium, phosphorus, manganese. compounds characterized using chromatographic analysis, FTIR, GC-MS, potential therapeutic with C-H C-O bonds amide group, β-glycosides, C-C/C-O vibrations phenolic substances. Mushroom extract at concentration 100 µg mL−1 exhibited potent antimicrobial activity against pathogens. This suggests that rich biochemical composition pharmacological potential, making it promising candidate drug development traditional medicine, contributes valuable insights into its diverse applications.

Язык: Английский

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Potential use of antioxidants for the treatment of chronic inflammatory diseases

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 16, 2024

The excessive production of various reactive oxidant species over endogenous antioxidant defense mechanisms leads to the development a state oxidative stress, with serious biological consequences. consequences stress depend on balance between generation and include damage biomolecules, disruption signal transduction, mutation, cell apoptosis. Accumulating evidence suggests that is involved in physiopathology debilitating illnesses associated chronic inflammation, including cardiovascular diseases, diabetes, cancer, or neurodegenerative processes, need continuous pharmacological treatment. Oxidative inflammation are tightly linked pathophysiological one which can be simply promoted by another. Although, many trials have been unsuccessful (some showed either no effect even harmful effects) human patients as preventive curative measure, targeting remains an interesting therapeutic approach for new agents design novel anti-inflammatory drugs reliable safety profile. In this regard, several natural compounds were explored potential options treatment inflammatory diseases. Several metalloenzymes, such superoxide dismutase, catalase, glutathione peroxidase, among essential enzymes maintain low nanomolar physiological concentrations (O 2 •−) hydrogen peroxide (H O ), major redox signaling molecules, thus play important roles alteration homeostasis. These become striking source motivation catalytic enhance action these under pathological conditions related inflammation. This review focused representatives synthetic antioxidants drug candidates

Язык: Английский

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Effect of Sustainable Pretreatments on the Nutritional and Functionality of Chickpea Protein: Implication for Innovative Food Product Development

Journal of Food Biochemistry, Год журнала: 2024, Номер 2024, С. 1 - 29

Опубликована: Фев. 7, 2024

Chickpea is a globally cultivated legume, rich in vitamins, protein, carbohydrates, polyphenols, fatty acids, fibers, and flavonoids. Despite its nutritional benefits, chickpeas contain antinutritional factors that can hinder nutrient absorption. Therefore, we reviewed the various pretreatment methods to enhance chickpea protein’s value functional properties. Thermal biochemical treatments food applications of protein are thoroughly reviewed. The review revealed physical, thermal, were reported be effective reducing improving solubility, emulsifying capacity, foaming proteins used cereals bakery products meet consumer demand. Encapsulation enhances stability, inclusion gluten-free has different effects on glycemic index, antioxidant activity, overall acceptability. These findings highlight chickpea’s potential improve aspects while offering health benefits consumers.

Язык: Английский

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A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Год журнала: 2025, Номер 11(3), С. e41654 - e41654

Опубликована: Янв. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Язык: Английский

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