Assessment of hippocampal-related behavioral changes in adolescent rats of both sexes following voluntary intermittent ethanol intake and noise exposure: a putative underlying mechanism and implementation of a non-pharmacological preventive strategy DOI Creative Commons
Gustavo Ezequiel Buján, Luciana D’Alessio, Héctor Alejandro Serra

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 19, 2023

Abstract Ethanol (EtOH) intake and noise exposure are particularly concerning among human adolescents because the potential to harm brain. Unfortunately, putative underlying mechanisms remain be elucidated. Moreover, although neuroprotection tools could aid prevent individuals from injury, limited data available. Using an adolescent animal model, present study aims explore a possible mechanism that underlie altered hippocampus-dependent behaviors induced by EtOH and/or exposure, as well neuroprotective impact of environmental challenge. Adolescent Wistar rats both sexes were subjected intermittent voluntary paradigm for one week. A subgroup animals was exposed white two hours after last session intake. Some groups housed in EE cages. Hippocampal-dependent behavioral assessment hippocampal oxidative state evaluation performed. Present results show different alterations might intake, with or without sequential noise, some cases sex-specific. imbalance seems mechanisms. Additionally, most prevented EE. These findings suggest recreational agents may behavior via pathways, sexes, model. In addition, improved housing resulted effective strategy. Therefore, it suggested non-pharmacological approach potentially provide advantages against other challenges. Finally, worth considering its translational benefit.

Язык: Английский

Advancements in Elucidating the Mechanisms of Central Nervous System Damage Induced by Infrasound Exposure DOI Open Access

Liu Xia,

Ci Li, Chunying Shi

и другие.

American Journal of Life Sciences, Год журнала: 2025, Номер 13(1), С. 7 - 13

Опубликована: Март 11, 2025

Infrasound, defined as sound waves with frequencies below 20 Hz, is gaining attention for its potential effects on human health, particularly the central nervous system (CNS). It can impact CNS through direct and indirect mechanisms, such damaging neuronal membranes, interfering neurotransmitter release, altering intracellular signaling, compromising blood-brain barrier. These may cause dysfunction, imbalances, increased oxidative stress, inflammation, affecting mood, cognition, memory. This review summarizes current understanding of infrasound's underlying aiming to provide a foundation future research applications.

Язык: Английский

Процитировано

0
Inhibition of astroglial hemichannels ameliorates infrasonic noise induced short-term learning and memory impairment DOI Creative Commons
Wei Zhang,

Jue Yin,

Beiyao Gao

и другие.

Behavioral and Brain Functions, Год журнала: 2023, Номер 19(1)

Опубликована: Дек. 18, 2023

Abstract As a kind of environmental noise, infrasonic noise has negative effects on various human organs. To date, research shown that infrasound impairs cognitive function, especially the ability for learning and memory. Previously, we demonstrated impaired memory induced by was closely related with glia activation; however, underlying mechanisms remain unclear. Connexin 43 hemichannels (Cx43 HCs), which are mainly expressed in hippocampal astrocytes, activated under pathological conditions, lending support to hypothesis Cx43 HCs might function infrasound. This study revealed blocking or downregulating expression significantly alleviated We also observed exposure led abundant release glutamate ATP through HCs. In addition, depended proinflammatory cytokines. Our finds suggested enhanced astroglial may be involved deficits caused exposure.

Язык: Английский

Процитировано

3
Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy DOI Creative Commons
Yifei Tang, Yajing Duan,

Rui-Dong Ge

и другие.

Journal of Integrative Neuroscience, Год журнала: 2022, Номер 22(1), С. 5 - 5

Опубликована: Ноя. 29, 2022

One of the most serious complications sepsis is sepsis-associated encephalopathy (SAE), which impairs cognition ability survivors. Environmental enrichment (EE) has been demonstrated to alleviate deficits under many kinds brain injury conditions. However, EE's effects on SAE remain unknown. Therefore, this study aimed determine effect disorders conditions and underlying mechanism.Adult male rats, subject or not, were housed a standard environment (SE) EE for 30 days. Subsequently, rats subjected cognitive tests, such as novel object recognition (NOR) test, Morris water maze (MWM) an Open Field (OF) elevated plus (EPM) sensory neglect (SN) test. Neuroinflammation, apoptosis, oxidative stress changes in also detected.The results revealed that impaired somatesthesia, memory, spatial learning exploratory activity, significantly improved by housing. prevented SAE-induced anxiety-like behavior. In addition, housing capable induced decrease pro-inflammatory cytokines, increase anti-inflammatory cytokines antioxidant properties brain. Moreover, exerted anti-apoptosis function upregulating level B-cell lymphoma/leukemia-2 (Bcl-2) downregulating p53 hippocampus.The present indicated exerts neuroprotective rats. The achieved increasing antioxidants, antiapoptotic capacities. can effectively rescue deficits.

Язык: Английский

Процитировано

3
Assessment of Hippocampal-Related Behavioral Changes in Adolescent Rats of both Sexes Following Voluntary Intermittent Ethanol Intake and Noise Exposure: A Putative Underlying Mechanism and Implementation of a Non-pharmacological Preventive Strategy DOI

GE Buján,

Luciana D’Alessio,

HA Serra

и другие.

Neurotoxicity Research, Год журнала: 2024, Номер 42(3)

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

0
Impact of Enriched Environment on Hippocampal-Dependent Behavioral Changes Induced by Extended Voluntary Ethanol Intake and Intermediate Noise Exposure in Male and Female Wistar Rats DOI
Gustavo Ezequiel Buján,

Gonzalo Corsi,

L Alessio

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Assessment of hippocampal-related behavioral changes in adolescent rats of both sexes following voluntary intermittent ethanol intake and noise exposure: a putative underlying mechanism and implementation of a non-pharmacological preventive strategy DOI Creative Commons
Gustavo Ezequiel Buján, Luciana D’Alessio, Héctor Alejandro Serra

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 19, 2023

Abstract Ethanol (EtOH) intake and noise exposure are particularly concerning among human adolescents because the potential to harm brain. Unfortunately, putative underlying mechanisms remain be elucidated. Moreover, although neuroprotection tools could aid prevent individuals from injury, limited data available. Using an adolescent animal model, present study aims explore a possible mechanism that underlie altered hippocampus-dependent behaviors induced by EtOH and/or exposure, as well neuroprotective impact of environmental challenge. Adolescent Wistar rats both sexes were subjected intermittent voluntary paradigm for one week. A subgroup animals was exposed white two hours after last session intake. Some groups housed in EE cages. Hippocampal-dependent behavioral assessment hippocampal oxidative state evaluation performed. Present results show different alterations might intake, with or without sequential noise, some cases sex-specific. imbalance seems mechanisms. Additionally, most prevented EE. These findings suggest recreational agents may behavior via pathways, sexes, model. In addition, improved housing resulted effective strategy. Therefore, it suggested non-pharmacological approach potentially provide advantages against other challenges. Finally, worth considering its translational benefit.

Язык: Английский

Процитировано

0