Informatics in Medicine Unlocked,
Год журнала:
2024,
Номер
47, С. 101509 - 101509
Опубликована: Янв. 1, 2024
Terminalia
Catappa
fruits
are
recognized
for
their
use
in
diabetes
treatment,
yet
the
mechanism
by
which
they
inhibit
diabetes-related
enzymes
remain
largely
undefined.
This
study
aimed
to
elucidate
therapeutic
potential
and
interactions
of
T.
catappa
fruit
extract
through
vitro
silico
approaches.
The
compounds
from
were
extracted
using
microwave-assisted
extraction
techniques,
followed
qualitative
phytochemical
screening
quantitative
analysis
via
GC-MS.
physicochemical
properties
evaluated
according
Lipinski
rule
ADMET
criteria.
Antidiabetic
analyses,
both
silico,
performed
on
secondary
metabolites
found
fruit,
targeting
α-amylase
α-glucosidase
enzymes.
methanol
ethyl
acetate
extracts
contained
alkaloids,
flavonoids,
saponins,
steroids,
terpenoids.
These
inhibited
a
dose-dependent
manner,
with
showing
significantly
higher
inhibitory
activity
than
pure
acarbose
(by
two-
five-fold,
respectively)
extract.
Furthermore,
antioxidant
methanolic
was
seven
times
greater
that
Molecular
docking
studies
supported
these
findings,
revealing
ΔG
values
gibberellic
acid,
rescinnamine,
digoxin
comparable
those
acarbose.
Notably,
has
against
acarbose,
while
nerolidol
showed
similar
Gibberellic
unique
extract,
demonstrated
high
values,
suggesting
its
significant
role
extract's
enhanced
glucosidase
amylase
activities.
identifies
specific
(digitoxin,
nerolidol)
proposes
multi-target
drugs
treatment.
Understanding
constituents
effects
diabetes-involved
could
benefit
individuals
type
2
diabetes,
particularly
at
risk
complications.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
150, С. 113038 - 113038
Опубликована: Апрель 28, 2022
Diabetes
mellitus
(DM)
is
a
real
challenge
to
the
recent
era
and
one
of
major
diseases
for
initiating
life-threatening
disorders.
In
current
research,
compound
was
designed
by
combining
vanillin,
thiazolidinedione
morpholine.
The
goal
our
work
demonstrate
ability
design
(9)
modulate
more
than
target
responsible
hyperglycemia
at
same
time.
synthesized
able
show
good
moderate
inhibition
potential
against
α-glucosidase,
α-amylase
protein
tyrosine
phosphatase
1B.
However,
it
exhibited
excellent
in-vitro
Dipeptidyl
peptidase-4
(DPP-4)
with
IC50
value
0.09
µM.
Antioxidant
activity
using
DPPH
assay
also
showed
its
antioxidant
potential.
in-vivo
experiments,
9
proved
be
safe
in
experimental
mice.
profile
observed
21
days
which
that
effective
Binding
orientations
Interactions
key
amino
acid
residues
selected
targets
were
studied
docking
studies.
Overall,
we
successful
synthesizing
multitarget
preclinical
therapeutic
three
pharmacophoric
moieties
into
single
chemical
entity
can
Journal of Food Quality,
Год журнала:
2022,
Номер
2022, С. 1 - 15
Опубликована: Июнь 15, 2022
Cancer
therapies
are
associated
with
various
challenges
including
the
emergence
of
multidrug
resistant
tumors,
toxicological
issues,
severe
side
effects,
and
economic
burden.
To
counteract
these
natural
products
as
substitutes
adjuvant
have
received
considerable
attention
owing
to
their
safety,
efficacy,
aspects.
Various
preclinical
clinical
studies
revealed
that
combinations
chemotherapeutics
mediate
anticancer
effects
via
modulation
signaling
pathways
implicated
in
promoting
apoptosis,
inhibiting
excessive
cellular
proliferation,
mobilizing
immune
system.
Several
lead
phytochemicals
curcumin,
resveratrol,
quercetin,
cannabinoids
synergistically
act
cancer
reducing
cell
proliferation
inducing
apoptosis
cycle
arrest.
However,
on
subject
matter
limited
need
further
extensive
studies.
It
has
been
observed
patients
undergoing
chemotherapy
use
alternative
ameliorate
symptoms
chemotherapeutic
agents.
Nevertheless,
some
inform
physicians
regarding
herbal
medicine
during
while
others
do
not,
even
most
not
know
composition
they
consume
chemotherapy.
Herbal
interactions
both
beneficial
harmful
aspects,
but
aspect
overweighs
ones
terms
controlling
Nonetheless,
a
large
number
medicines
demonstrated
synergistic
effect
alleviate
The
concomitant
majority
be
multiple
malignant
tumors
like
blood,
lungs,
kidneys,
liver,
skin,
gastrointestinal
tract.
which
possess
positive
interaction
improve
quality
life
should
sorted
out
integrated
There
control
system
for
appraisal
medicine,
there
also
an
appropriate
patient-doctor
communication
counsel
deleterious
combination
ACS Omega,
Год журнала:
2022,
Номер
7(50), С. 46358 - 46370
Опубликована: Дек. 8, 2022
Diabetes
mellitus
(DM)
is
a
complex
and
multiple
group
of
disorders,
understanding
the
molecular
mechanisms
key
role
in
identifying
various
markers
involved
diagnosis
disease.
Brucine
derived
from
seeds
Strychnos
nux-vomica
L.
(Loganiaceae),
which
has
been
used
traditional
medicine
to
cure
variety
ailments,
such
as
chronic
rheumatism,
nervous
system
diseases,
dyspepsia,
gonorrhea,
anemia,
bronchitis,
analgesic,
anti-inflammatory,
anti-oxidant,
anti-snake
venom,
anti-diabetic
properties.
The
potential
brucine
was
studied
utilizing
vitro,
silico,
vivo,
methods,
including
streptozotocin-induced
diabetic
rat
models,
α-glucosidase
α-amylase
inhibitory
assays,
via
Auto-DocVina
software.
exhibits
binding
affinities
-5.0
-10.1
Kcal/mol
against
chosen
protein
targets,
according
an
silico
investigation.
In
vitro
studies
revealed
that
inhibited
enzymes
α-glucosidase,
(20
mg/kg)
reduced
blood
glucose
levels,
oral
tolerance
overload,
body
weight,
glycosylated
hemoglobin
total
cholesterol,
triglycerides,
low-density
lipoprotein,
alanine
transaminase,
aspartate
aminotransferase,
bilirubin,
alkaline
phosphatase
elevated
high-density
lipoprotein
levels
vivo
studies.
energy
certain
targets
ranges
Kcal/mol.
It
anti-diabetic,
anti-hyperlipidemic,
hepatoprotective,
anti-inflammatory
properties,
are
mediated
inhibition
α-amylase.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16501 - 16501
Опубликована: Ноя. 19, 2023
Since
the
earliest
times,
essential
oils
(EOs)
have
been
utilized
for
medicinal
and
traditional
purposes.
However,
in
recent
decades,
an
increasing
interest
has
developed
due
to
need
rediscover
herbal
remedies
adjuvant
therapies
management
of
various
diseases,
particularly
chronic
ones.
The
present
narrative
review
examines
potential
EOs
exert
hypoglycemic
antioxidant
effects
diabetes
mellitus,
analyzing
main
publications
having
evaluated
plant
species
with
potentially
beneficial
through
their
phytocompounds
mellitus
its
complications.
Numerous
shown
promising
characteristics
that
can
be
used
management.
these
are
attributed
capacity
stimulate
glucose
uptake,
suppress
production,
increase
insulin
sensitivity.
Moreover,
alleviate
oxidative
stress
by
manifesting
via
a
variety
mechanisms,
including
scavenging
free
radicals,
regulation
enzymes,
decreasing
lipid
peroxidation,
diverse
chemical
composition.
These
findings
demonstrate
possible
benefits
as
therapeutic
agents
use
treatment
shows
good
development
natural
effective
strategies
enhance
health
outcomes
people
this
condition,
but
additional
experimental
endorsements
required.
Journal of Natural Remedies,
Год журнала:
2025,
Номер
unknown, С. 141 - 150
Опубликована: Янв. 31, 2025
Background:
Various
species
of
the
genus
Allium
have
been
reported
to
exhibit
antidiabetic
potential.
Among
various
species,
stracheyi
Baker
is
one
most
popular
and
important
ethnobotanical
traditional
perennial
Himalayan
seasoning
herbs
belonging
family
Alliaceae.
Since
no
scientific
studies
carried
out
assess
potential
in
reducing
blood
sugar
levels.
Therefore,
present
research
work
aimed
screen
different
leaf
extracts
for
presence
bioactive
phytochemicals
evaluate
vitro
each
extract.
Aim:
To
ascertain
phytochemical
composition
by
using
preliminary
qualitative
quantitative
screening
methods
assessment
enzymatic
assays.
Methods:
The
successive
extraction
was
a
sequence
solvents
with
increasing
polarity
including
petroleum
ether,
methanol,
hydroalcoholic
water
soxhlation
apparatus.
concentrated
were
subjected
analysis
or
absence
active
their
quantity
extract
followed
determination
application
standard
Results:
Phytochemical
on
confirmed
phytochemicals.
Results
showed
that
methanolic
possesses
highest
amount
phenolic
flavonoids
which
may
contribute
plant.
All
demonstrated
marked
(α-amylase
α-glucosidase)
Additionally,
only
tested
significant
Conclusion:
Research
findings
concluded
methanol
exhibited
because
existence
compounds
as
well
majority.
Further
additional
plant
are
strongly
suggested
isolate
purify
major
phenolics
from
confirm
its
vivo
studies.
Major
Findings:
This
study’s
main
finding
that,
all
extracts,
effective
at
inhibiting
activity
alpha-glucosidase
enzyme
(IC50=32.92
μg/ml
100
μg/ml)
alpha-amylase
(IC50=50.51
μg/m
μg/ml),
suggests
it
be
used
treat
diabetes.
high
concentration
polyphenolic
chemicals,
tannins,
steroids,
alkaloids,
saponins,
what
causes
this
activity.
BMC Complementary Medicine and Therapies,
Год журнала:
2022,
Номер
22(1)
Опубликована: Июнь 13, 2022
The
study
was
planned
to
investigate
the
phytochemicals,
antidiabetic
and
antioxidant
studies
of
A.
consanguineum.The
preliminary
were
performed
on
crude
extract
different
solvent
fractions.
Based
potency,
chloroform
fraction
semi-purified
phyto-fractions
CHF-1
-
5.
Furthermore,
CHF-3
subjected
isolation
pure
compounds
using
column
chromatography.
α-glucosidase,
α-amylase
assays
(DPPH,
ABTS,
H2O2)
all
samples.
in-vivo
experiments
1
2
also
oral
glucose
tolerance
test.
Docking
α-glucosidase
targets.Among
fractions,
exhibited
excellent
activities
profile
giving
IC50
values
824,
55,
117,
58
85
μg/ml
against
α-amylase,
DPPH,
ABTS
H2O2
targets
respectively.
Among
five
(CHF-1-5),
leading
in
85.54,
61.19
26.58
DPPH
overall
potency
physical
amount
CHF-3,
it
purification
get
2.
two
found
potent
in-vitro
activities.
observed
for
compound
7.93,
28.01
6.19
Similarly,
14.63,
24.82
7.654
Compounds
decreasing
blood
levels
experimental
animals.
showed
interactions
with
respective
enzymes
molecular
docking.We
can
conclude
that
Consanguineum
is
a
rich
source
natural
agents.
Bioguided
potential
inhibitions
tested
targets.
Further,
both
able
decrease
