The Design and Testing of an Additive Manufacturing-Obtained Compliant Mechanism for the Complex Personalisation of Lenses in Clinical Optometry DOI Creative Commons
Victor Constantin, Daniel Comeagă, Bogdan Grămescu

и другие.

Applied Sciences, Год журнала: 2023, Номер 13(24), С. 13010 - 13010

Опубликована: Дек. 6, 2023

The precision needed in optometric measurements for the correct customization of progressive lenses usually falls short what is required accurate prescriptions. This stems from fact that most are obtained using outdated methods, employing either rulers or protractors. While there equipment available precise measurements, cost purchase and ownership prohibitive. In this context, due to constant progress high-resolution cameras along with processing power handheld devices, another solution has presented itself different iterations past decade, as put forward by manufacturers optical lenses. Such a system comprises mobile computing device image capture capabilities (tablet smartphone), marker support be mounted on user’s glasses frames. Aside cost, ease implementation usage, advantage such parameters, measured, allow better customization, since eyewear already position which it will used. It allows optometrist measure parameters interpupillary distance, pantoscopic angle curvature relation own specific shape size. paper proposes model easy use, precise, low minimal impact optometrist. As such, examines steps determining supports need taken; finite element analysis was proposed, various tests modifications were made until material combination found satisfied all required. An experimental produced tested wide variety frames good results, following work.

Язык: Английский

Unraveling the mechanobiology of cornea: From bench side to the clinic DOI Creative Commons
Shu Juan Yang, Jing Zhang, Youhua Tan

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Окт. 3, 2022

The cornea is a transparent, dome-shaped structure on the front part of eye that serves as major optic element and protector from external environment. Recent evidence shows aberrant alterations corneal mechano-environment in development progression various diseases. It is, thus, critical to understand how cells sense respond mechanical signals physiological pathological conditions. In this review, we summarize discuss impact these cues cellular functions bench side (in laboratory research setting). From clinical perspective, comprehensively review changes tissue several cornea-related diseases, including keratoconus, myopia, keratectasia, following refractive surgery. findings clinic underscore involvement disorders, which may open new avenue for novel therapeutic strategies by targeting mechanics.

Язык: Английский

Процитировано

14
Contact lens fitting and changes in the tear film dynamics: mathematical and computational models review DOI Creative Commons
Darshan Ramasubramanian, José Luis Hernández‐Verdejo,

José M. López-Alonso

и другие.

Graefe s Archive for Clinical and Experimental Ophthalmology, Год журнала: 2024, Номер 262(9), С. 2751 - 2764

Опубликована: Март 2, 2024

This review explores mathematical models, blinking characterization, and non-invasive techniques to enhance understanding refine clinical interventions for ocular conditions, particularly contact lens wear.

Язык: Английский

Процитировано

2
Finite Element Analysis of Cornea and Lid Wiper during Blink, with and without Contact Lens DOI Creative Commons
Vivek Suganthan Ramasubramanian,

S. Sundaram,

Rinu Thomas

и другие.

Journal of Ophthalmology, Год журнала: 2022, Номер 2022, С. 1 - 13

Опубликована: Май 17, 2022

Ocular surface disorders such as Lid Wiper Epitheliopathy (LWE), Superior Epithelial Arcuate Lesion (SEAL), and contact lens-induced Limbal Stem Cell Deficiency (LSCD) well Limbic Keratoconjunctivitis (SLK) affect one's quality of life. Hence, it is imperative to investigate the underlying causes these ocular disorders. During blink, undersurface eyelid tends interact with cornea conjunctiva. The presence a lens can add biomechanical frictional changes on surfaces. To estimate without lens, finite element model (FEM) wiper, eyeball, was developed using COMSOL Multiphysics. Biomechanical properties von Mises stress (VMS) displacement were calculated. Our study concluded that (a) maximum VMS observed in lid wiper absence eye (b) superior 1.3 mm eye. Thus, development friction-induced LWE, SLK, SEAL, LSCD could be attributed increased VMS. FEA useful simulation tool helps us understand effect blink normal CL.

Язык: Английский

Процитировано

9
Influence of Contact Lens Parameters on Cornea: Biomechanical Analysis DOI Creative Commons
Darshan Ramasubramanian, José Luis Hernández‐Verdejo,

José M. López-Alonso

и другие.

Bioengineering, Год журнала: 2024, Номер 11(10), С. 966 - 966

Опубликована: Сен. 27, 2024

This study presents a finite element analysis to model ocular biomechanics and the interactions between human eye contact lenses in closed-eye condition. The state, where eyelids are fully shut, challenges for experimental measurements due invasive nature of accessing analysing lens corneal interface, making simulation tools valuable accurate characterisation. primary objective this was examine how CLs fold twist their impact on cornea when is closed. secondary aim assess crucial parameters (Young’s modulus, base curve, diameter) influence stress distribution overall fit eye. findings show that increasing Young’s modulus significantly reduces promotes uniform distribution, it most influential factor wearer comfort safety. While curve diameter variations primarily affect area, minimal. research provides insights improving design enhancing safety wearers.

Язык: Английский

Процитировано

1
A Review of Contact Lens-Induced Limbal Stem Cell Deficiency DOI Creative Commons

Y. F. Lee,

Dayna Wei Wei Yong,

Manotosh Ray

и другие.

Biology, Год журнала: 2023, Номер 12(12), С. 1490 - 1490

Опубликована: Дек. 5, 2023

Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and destruction of cells, precursors limbal niche in corneal epithelium, leading to severe conjunctivalization cornea. Etiologies for LSCD span from congenital (aniridia), traumatic (chemical or thermal injuries), autoimmune (Stevens-Johnson syndrome) iatrogenic disease contact lens (CL) wear. Of these, CL wear least understood often subclinical cause LSCD. Even with recent advances research, limitations persist establishing pathogenesis treatment guidelines CL-induced A literature search was conducted include original articles containing patients This review will critically discuss complex pathophysiology behind LSCD, underlying risk factors epidemiology as well methods obtain diagnosis. Various options be reviewed based on proposed strategies.

Язык: Английский

Процитировано

3
The effect of type 2 diabetes mellitus on lid wiper epitheliopathy and ocular surface parameters DOI Creative Commons

Meiting Huang,

Xiaoming Yan, Yuan Gao

и другие.

Heliyon, Год журнала: 2024, Номер 10(17), С. e36912 - e36912

Опубликована: Авг. 26, 2024

This cross-sectional study was conducted to investigate the impact of type 2 diabetes mellitus(DM) and its duration on indicators such as lid wiper epitheliopathy(LWE), assess significance LWE for early diagnosis dry eye disease(DED) in DM patients.

Язык: Английский

Процитировано

0
Mathematical Models of Drug Delivery via a Contact Lens During Wear DOI Creative Commons
Daniel Anderson, Rayanne A. Luke

La Matematica, Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

Abstract In this work we develop and investigate mathematical computational models that describe drug delivery from a contact lens during wear. Our are designed to predict the dynamics of release subsequent transport into adjacent pre-lens tear film post-lens as well ocular tissue (e.g. cornea), eyelid, out these regions. These processes modeled by one dimensional diffusion coupled compartment-type for concentrations in various accompanying addition numerical solutions compared with experimental data on an vitro eye model, also identify large limit model which analytical can be written down all quantities interest, such cumulative lens. We use our make assessments about possible mechanisms pathways through films provide interpretation observations. discuss successes limitations their potential guide further research help understand ophthalmic via drug-eluting lenses.

Язык: Английский

Процитировано

0
A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks DOI Creative Commons
Guofei Pang, Chenyan Wang, Xiaojun Wang

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Окт. 15, 2024

The cornea is a vital tissue of the human body. health status has great impact on quality life person. There been deal research biomechancis. However, difficulty in obtaining greatly limited Using finite element modelling become very effective and economical means for studying mechanical properties cornea. In this review, geometrical constitutive models are summarised analysed, respectively. Some factors affecting calculation discussed. addition, prospects challenges model presented. This review will be helpful to researchers performing studies relevant fields analysis.

Язык: Английский

Процитировано

0
The Design and Testing of an Additive Manufacturing-Obtained Compliant Mechanism for the Complex Personalisation of Lenses in Clinical Optometry DOI Creative Commons
Victor Constantin, Daniel Comeagă, Bogdan Grămescu

и другие.

Applied Sciences, Год журнала: 2023, Номер 13(24), С. 13010 - 13010

Опубликована: Дек. 6, 2023

The precision needed in optometric measurements for the correct customization of progressive lenses usually falls short what is required accurate prescriptions. This stems from fact that most are obtained using outdated methods, employing either rulers or protractors. While there equipment available precise measurements, cost purchase and ownership prohibitive. In this context, due to constant progress high-resolution cameras along with processing power handheld devices, another solution has presented itself different iterations past decade, as put forward by manufacturers optical lenses. Such a system comprises mobile computing device image capture capabilities (tablet smartphone), marker support be mounted on user’s glasses frames. Aside cost, ease implementation usage, advantage such parameters, measured, allow better customization, since eyewear already position which it will used. It allows optometrist measure parameters interpupillary distance, pantoscopic angle curvature relation own specific shape size. paper proposes model easy use, precise, low minimal impact optometrist. As such, examines steps determining supports need taken; finite element analysis was proposed, various tests modifications were made until material combination found satisfied all required. An experimental produced tested wide variety frames good results, following work.

Язык: Английский

Процитировано

1