STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS
Aspects of Molecular Medicine,
Год журнала:
2025,
Номер
5, С. 100062 - 100062
Опубликована: Янв. 5, 2025
A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 141394 - 141394
Опубликована: Фев. 1, 2025
Язык: Английский
Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 375 - 375
Опубликована: Март 15, 2025
Recent
progress
in
material
science
has
led
to
the
development
of
new
drug
delivery
systems
that
go
beyond
conventional
approaches
and
offer
greater
accuracy
convenience
application
therapeutic
agents.
This
review
discusses
evolutionary
role
nanocarriers,
hydrogels,
bioresponsive
polymers
enhanced
release,
target
accuracy,
bioavailability.
Oncology,
chronic
disease
management,
vaccine
are
some
applications
explored
this
paper
show
how
these
materials
improve
results,
counteract
multidrug
resistance,
allow
for
sustained
localized
treatments.
The
also
translational
barriers
bringing
advanced
into
clinical
setting,
which
include
issues
biocompatibility,
scalability,
regulatory
approval.
Methods
overcome
challenges
surface
modifications
reduce
immunogenicity,
scalable
production
methods
such
as
microfluidics,
harmonization
systems.
In
addition,
convergence
artificial
intelligence
(AI)
machine
learning
(ML)
is
opening
frontiers
personalized
medicine.
These
technologies
predictive
modeling
real-time
adjustments
optimize
needs
individual
patients.
use
can
be
applied
rare
underserved
diseases;
thus,
strategies
gene
therapy,
orphan
drugs
development,
global
distribution
may
hopes
millions
Язык: Английский
A Model of a “Smart” Thermoresponsive Composite with Convertible Surface Geometry Controlled by the Magnetocaloric Effect
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 97 - 97
Опубликована: Фев. 21, 2025
A
model
of
a
“smart”
composite
based
on
thermosensitive
PNIPAM
polymer
deposited
FeRh
substrate
with
modified
periodic
microstructure
was
proposed.
The
initial
parameters
the
were
determined
from
properties
actual
sample
and
its
components.
Cooling
using
magnetic
field
shown
by
two
independent
methods,
at
~37
°C,
it
−5.5
°C
when
1.8
T
applied.
Based
experimental
data,
models
traditional
PNIPAM/FeRh
composites
constructed.
Calculations
show
that
surface
modification
allows
for
an
increase
in
activation
time
layer
is
20
µm
thick
~20
ms
conventional
to
~60
composite.
Modification
form
wells
can
be
used
more
effectively
implement
idea
loading
releasing
drugs
potential
biomedical
applications.
Язык: Английский
Smart Poly(N-isopropylacrylamide)-Based Hydrogels: A Tour D’horizon of Biomedical Applications
Gels,
Год журнала:
2025,
Номер
11(3), С. 207 - 207
Опубликована: Март 15, 2025
Hydrogels
are
innovative
materials
characterized
by
a
water-swollen,
crosslinked
polymeric
network
capable
of
retaining
substantial
amounts
water
while
maintaining
structural
integrity.
Their
unique
ability
to
swell
or
contract
in
response
environmental
stimuli
makes
them
integral
biomedical
applications,
including
drug
delivery,
tissue
engineering,
and
wound
healing.
Among
these,
“smart”
hydrogels,
sensitive
such
as
pH,
temperature,
light,
showcase
reversible
transitions
between
liquid
semi-solid
states.
Thermoresponsive
exemplified
poly(N-isopropylacrylamide)
(PNIPAM),
particularly
notable
for
their
sensitivity
temperature
changes,
transitioning
near
lower
critical
solution
(LCST)
approximately
32
°C
water.
Structurally,
PNIPAM-based
hydrogels
(PNIPAM-HYDs)
chemically
versatile,
allowing
modifications
that
enhance
biocompatibility
functional
adaptability.
These
properties
enable
application
diverse
therapeutic
areas
cancer
therapy,
phototherapy,
healing,
engineering.
In
this
review,
the
behavior
smart
PNIPAM
explored,
with
an
emphasis
on
synthesis
methods
brief
note
biocompatibility.
Furthermore,
PNIPAM-HYDs
detailed,
along
applications
skin
conditions,
ocular
diseases,
etc.
Various
delivery
routes
patents
highlighting
advancements
also
examined.
Finally,
future
prospects
remain
promising,
ongoing
research
focused
enhancing
stability,
responsiveness,
clinical
applicability.
continued
development
is
expected
revolutionize
technologies,
paving
way
more
efficient
targeted
solutions.
Язык: Английский
Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Biosensors
serve
as
indispensable
analytical
tools
in
biomedical
diagnostics,
environmental
monitoring,
and
personalized
healthcare,
offering
operation
simplicity,
cost-effectiveness,
high
sensitivity,
portability.
Nanostructure
integration
has
overcome
traditional
sensing
platform
limitations,
particularly
sensitivity
response
dynamics.
These
nanoscale
materials-including
nanoparticles,
nanowires,
nanosheets,
nanotubes-leverage
unique
physicochemical
properties
such
surface-to-volume
ratio,
quantum
confinement
effects,
plasmonic
interactions
to
enhance
biosensor
performance
significantly.
This
review
systematically
analyzes
recent
advances
nanostructure-based
biosensing
technologies,
examining
how
nanomaterial
engineering
improves
sensor
selectivity,
multifunctionality.
Fundamental
mechanisms
are
explored
by
which
nanostructures
electrochemical,
optical,
electrical
performance,
emphasizing
low-abundance
biomarkers
complex
biological
matrices.
Beyond
technological
innovations,
practical
applications
evaluated
across
healthcare
monitoring.
Finally,
current
challenges
outline
future
research
directions,
highlighting
these
technologies'
potential
addressed
transform
diagnostic
capabilities
outcomes.
Язык: Английский
Engineering of a hemostatic and antibacterial sealant based on oxidized tannic acid-chitosan containing gentamicin sulfate-imprinted tine oxide for surgical adhesives
Carbohydrate Polymer Technologies and Applications,
Год журнала:
2025,
Номер
unknown, С. 100810 - 100810
Опубликована: Апрель 1, 2025
Язык: Английский
Silver nanoparticle‐infused hydrogels for biomedical applications: A comprehensive review
Journal of the Chinese Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
Recent
advancements
in
biomedical
applications
have
highlighted
the
need
for
nontoxic
and
organic
materials
with
versatile
capabilities.
Silver
nanoparticles
(AgNPs)
emerged
as
a
promising
antimicrobial
agent
due
to
their
exceptional
physicochemical
properties,
whereas
hydrogels
offer
potential
biomedicine
biocompatibility,
biodegradability,
hydrophilicity.
AgNPs‐infused
hydrogel
can
synergistic
approach
various
applications,
specifically
wound
healing,
drug
delivery,
coatings.
The
incorporation
of
AgNPs
into
enhances
making
them
ideal
reducing
infections
promoting
tissue
regeneration.
Furthermore,
serve
controlled‐release
systems
therapeutic
agents,
which
ensures
sustained
targeted
delivery.
Most
importantly,
this
type
system
offers
pathway
overcoming
challenges
posed
by
traditional
materials.
While
significant
advantages
such
cytotoxicity,
environmental
concerns,
long‐term
effects
require
further
investigation.
Overall,
review
comprehensively
explores
synthesis
methods,
associated
hydrogel.
Язык: Английский