Ginsenoside Rg1 in Parkinson’s disease: from basic research to clinical applications

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

This review provides an in-depth exploration of the potential Ginsenoside Rg1 in treatment Parkinson’s disease (PD). The emphasis this article was therapeutic mechanisms Rg1, which involved reduction inflammation, antioxidant properties, support for neuronal survival and regeneration, regulation cellular energy processes, enhancement autophagic pathways. may protect neurons improve both motor cognitive impairments associated with PD through multiple mechanisms. However, challenges exist clinical application such as low bioavailability well a lack comprehensive long-term safety efficacy data. also reviewed network pharmacology analyses published previously to identify explore molecular targets treatment, while evaluating strategies drug delivery technologies, optimizing administration routes, combination therapies. Ultimately, highlights necessity large-scale trials validate discusses its clinically.

Язык: Английский

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Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism of Protopanaxadiol Triphenylphosphate Derivative in Non-Small-Cell Lung Cancer

Molecules, Год журнала: 2024, Номер 29(17), С. 4275 - 4275

Опубликована: Сен. 9, 2024

The objective of this study was to enhance the membrane permeability and anticancer effectiveness (20S)-protopanaxadiol (PPD) by introducing triphenylphosphonium into OH group at C-3 site. This shows that anti-proliferation activity CTPPPPD, with an IC50 value 1.65 ± 0.10 μmol/L, 33-times better than PPD (with 54.56 4.56 μmol/L) superior cisplatin 1.82 0.25 against A549 cells. Biological examinations suggested CTPPPPD treatment reduced growth rate cells, increased cell membranes, changed structure chromosomal DNA in a concentration-dependent manner. Annexin V/PI assay flow cytometry were employed detect effect on apoptosis results showed could induce cells treated 0, 1.0, 2.0, 4.0 μM for 24 h 0%, 4.9%, 12.7%, 31.0%, respectively. integration transcriptomics metabolomics provided systematic detailed perspective induced antitumor mechanisms. A combined analysis DEGs DAMs they primarily involved central carbon metabolism pathway cancer, as well aminoacyl-tRNA biosynthesis, alanine, aspartate, glutamate. Central cancer-related genes, i.e., SLC16A3, FGFR3, LDHA, PGAM1, SLC2A1, significantly after CTPPPPD. In particular, dominant mechanism responsible total may be attributed perturbations PI3K-AKT, MAPK, P53 pathways. findings derived from empirically confirmed through q-PCR molecular docking. Further analyses revealed promising lead development protopanaxadiol non-small-cell lung cancer (NSCLC) drugs.

Язык: Английский

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Efficacy and safety of YOXINTINE for depression: a double-blinded, randomized, placebo-controlled, phase 2 clinical trial

Phytomedicine, Год журнала: 2024, Номер 136, С. 156204 - 156204

Опубликована: Ноя. 14, 2024

Язык: Английский

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Coinhibitory Effects of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extracts Against Melanogenic Activities in Melan-a Cells

Plants, Год журнала: 2024, Номер 13(23), С. 3385 - 3385

Опубликована: Дек. 1, 2024

In the current study, we aimed to evaluate combined antimelanogenic effects of resveratrol- and protopanaxadiol (PPD)-enriched rice seed extracts (DJ526 DJ-PPD) in melan-a cells. The treatment antioxidant capacity was evaluated using ABTS radical scavenging method. TR_3 (70% [wight (

Язык: Английский

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A GH1 β-glucosidase from the Fervidobacterium pennivorans DSM9078 showed extraordinary thermostability and distinctive ability in the efficient transformation of ginsenosides

Bioorganic Chemistry, Год журнала: 2024, Номер 154, С. 108049 - 108049

Опубликована: Дек. 9, 2024

Язык: Английский

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