Transplantation and Cellular Therapy, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
JAMA Network Open, Год журнала: 2025, Номер 8(1), С. e2449556 - e2449556
Опубликована: Янв. 3, 2025
Research indicates that social drivers of health are associated with cancer screening adherence, although the exact magnitude these associations remains unclear.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Background: Puerto Rico, a United States (U.S.) territory with 99% of its inhabitants identifying as Hispanic/Latino, has one the most rapid aging populations in world. In this study, we quantified incidence and mortality cancer among 85+ year-old residents compared these rates Hispanic/Latino U.S. Methods: We accessed age-adjusted (2005-2021) from Cancer Statistics North American Association Centralized Registries datafiles. Cancers were restricted to males females age 85+. addition analyzing Rico data, also analyzed data nine states unsuppressed rates. calculated annual percentage changes (APCs), Mortality-Incidence Ratios (MIR), Standardized Incidence Mortality (SIRs, SMRs) for all cancers specific sites. Results: Since 2001, both aged declined. The declines male (APC =-3.1%) =-3.3% annually) particularly pronounced, exceeding those observed comparable However, 2021, MIR (0.73) (0.94) higher than state MIRs. Between 2005 proportion diagnosed at advanced stages increased by 12%. Conclusions: While significant progress been made reducing Rico's oldest residents, challenges persist. Addressing survivorship through improved healthcare access policies tailored psychosocial support programs could help reduce burden population. Data revealing disaggregated ethnicity nationality beyond further inform targeted efforts advance equity across
Язык: Английский
Процитировано
0
BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 11, 2025
Compared to older adults with breast cancer (BC), adolescents and young (AYAs) develop more aggressive disease necessitating intensive therapy curative intent, which is disruptive planned life trajectories. The burden of unmet needs among AYA BC survivors exists in two domains: (1) symptoms (e.g., sexual problems, anxiety, fatigue, stress, hot flashes) (2) concerns fertility, genetics, relationships, economic attainment). Improved attention may improve symptom management quality life. Young, Empowered Strong (YES) trial tests the efficacy a 9-month, multicomponent digital health intervention that includes monthly assessments prevalent symptoms, chat room, journal engage support AYAs by providing tailored information, resources, outside clinical setting. YES multicenter, randomized controlled across three academic institutions United States 400 participants either or usual care arm. Inclusion criteria include biologically female; 15-39 years age at diagnosis stage 0-III BC; within 3 diagnosis; no known evidence recurrence; prior history new malignancy since initial ability access medical records from treatment site. All complete REDCap surveys baseline, 3, 6, 9 months post-enrollment. primary outcome as measured Quality Life Adult Cancer Survivors Scale (QLACS), changes baseline 6-months QLACS scores, compared Secondary outcomes patient reported concerns/needs, emotional general health, physical behaviors, DISCUSSION: Study findings will provide valuable insight into address assist them track self-manage their own concerns, related clinic. Clinicaltrials.gov, NCT04906200, registered May 13, 2021.
Язык: Английский
Процитировано
0
Cancer Investigation, Год журнала: 2025, Номер unknown, С. 1 - 8
Опубликована: Фев. 8, 2025
Background Human immunodeficiency virus is associated with the development of various aggressive non-Hodgkin B-cell lymphomas (NHL). Despite this, people living HIV (PLWH) are often excluded from clinical trials. Here we analyze change in trial exclusion among PLWH resulting multilateral advocacy efforts since 2017.
Язык: Английский
Процитировано
0
Advances in Oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Neurosurgical Review, Год журнала: 2025, Номер 48(1)
Опубликована: Фев. 19, 2025
Abstract Purpose The objective of this study was to evaluate the reporting racial, ethnic, and socioeconomic data in clinical trials exploring management metastatic spine disease (MSD). Methods We undertook a cross-sectional analysis North American completed published registered on ClinicalTrials.gov patients with MSD. Data patient demographics, trial characteristics, race ethnicity, distribution racial ethnic groups, measures extracted from related publications identified through PubMed Google Scholar searches. An exploratory performed, followed by Pearson’s Chi-square binary logistic regression analyses explore associations covariates racioethnic reporting. Results Out 158 trials, only 8% (12 158) met inclusion criteria results. These 12 included total 1,568 mean age 61 years. Almost half (42%; (5 12)) did not report race, while 17% (2 12) reported ethnicity. In complete ( n = 5), 77% (377 493) were White, 15% 73) Black or African American, 4% 19) Asian. Indian/Alaska Native Hawaiian/Other Pacific Islander severely underrepresented (0.4% 0.2%, respectively). Of two 94% (479 514) Not Hispanic Latino. Sponsoring body trial, phase, intervention type, number patients, significantly associated Notably, no any status. Conclusion Our review revealed significant gaps MSD substantial underrepresentation minority groups. This limits generalizability findings may perpetuate health disparities. Coordinated efforts researchers, clinicians, policymakers, funding bodies are needed improve diversity future trials. Strategies such as targeted outreach, community engagement, more inclusive eligibility should be implemented ensure that populations better reflect general population.
Язык: Английский
Процитировано
0
Current Oncology Reports, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
Leukemia & lymphoma/Leukemia and lymphoma, Год журнала: 2025, Номер unknown, С. 1 - 11
Опубликована: Апрель 1, 2025
Acute myeloid leukemia (AML) poses complex management challenges and requires specialized care. Academic cancer centershave multidisciplinary teams, offer rapid advanced diagnostics, provideaccess to novel therapies. Community centers provide care closer home, especially for underserved rural populations, but their resources expertise vary. Effective collaboration between academic community centerscanimproveaccess therapies, reduce treatment disparities, bringcare home. However, barriers such as delayed referrals, resource constraints, communication gaps complicate collaboration.Timely referral emergencies serious complications is critical. Bidirectional communication, including shared electronic health records telemedicine, essential when patients are co-managed across centers. System-level strategies, networks, patient navigators, transportation assistance, can further address these challenges. Developing integrated models standardized guidelines will enhance collaboration, enabling high-quality personalized individuals with AML.
Язык: Английский
Процитировано
0
JNCI Journal of the National Cancer Institute, Год журнала: 2024, Номер unknown
Опубликована: Авг. 27, 2024
Abstract The central premise of this article is that a portion the established relationships between social determinants health and racial ethnic disparities in cancer morbidity mortality mediated through differences rates biological aging processes. We further posit using knowledge about could enable discovery testing new mechanism-based pharmaceutical behavioral interventions (“gerotherapeutics”) to differentially improve survivors from minority populations reduce disparities. These hypotheses are based on evidence lifelong adverse contribute (“social aging”), with individuals minoritized groups experiencing accelerated (ie, steeper slope or trajectory over time relative chronological age) more often than nonminoritized groups. Acceleration can increase risk, age onset, aggressiveness, stage many adult cancers. There also documented negative feedback loops whereby cellular damage caused by its therapies act as drivers additional aging. Together, these dynamic intersectional forces outcomes vs populations. highlight key targetable mechanisms potential applications reducing discuss methodological considerations for preclinical clinical impact gerotherapeutics Ultimately, promise will require broad societal policy changes address structural causes ensure equitable access all control paradigms.
Язык: Английский
Процитировано
2
Cancer Epidemiology Biomarkers & Prevention, Год журнала: 2024, Номер 33(9), С. 1143 - 1146
Опубликована: Сен. 3, 2024
I cannot believe that it has been more than 5 years since began as the Cancer Epidemiology, Biomarkers & Prevention (CEBP) Editor-in-Chief! As leading subspecialty journal for scientifically meritorious reports on fundamental and applied population-based population-focused cancer research, CEBP serves our field is thought of fondly by editors, authors, readers alike. At AACR annual meeting each year, multiple attendees in Meet Editor session convey—with great enthusiasm—that was published their first ever research article. have noticed some NCI-Designated Comprehensive Centers list a high-impact population science. articles are policy- guideline-informing, receiving over 300 mentions US global policy documents 2020 (the start pandemic). am sure you will agree staff Journals truly expert scientific publishing, making process rigorous, fair, efficient. And these many reasons, so proud CEBP.It time another update few thoughts.The fared well during pandemic continues to be strong measured quality publications submitted published, speed review publication, extent use content. We 1,100 across full range CEBP's scope. The content widely cited field, amassing 9,000 citations date and, addition, 10,000 news, blogs, social media.Recently, made changes apply might want know about.•To increase transparency reporting thus, reproducibility, Materials Methods section no longer counts toward article length requirements, word limit type remains same. This means need move chunks supplement when limit! Authors also encouraged utilize available resources, including SciScore, RRIDs, Code Ocean, improve rigor reproducibility.•Leveraging technology enhance discoverability dissemination, now exclusively online. For special conferences events, printed material may available, print-on-demand issues can requested members.•To boost accessibility publishing expand perspectives, offers country-specific discounts publication charges (excluding open access). present, authors from only 34 countries pay price, other afforded 25%, 50%, or 100% waiver based primary affiliation corresponding author.•To ensure integrity, all manuscripts after peer screened plagiarism detection system, images subject automated screening image duplication manipulation. In about generative AI writing assistance.Because we aim serve impactful, editors take author reader feedback seriously. A colleague reminded us intentional considering diversity editorial aspects. We, staff, reflected people processes, recognized could do better. charged senior editor subcommittee with developing Guiding Principles. talented Gregory Pavlovcak, managing editor, crafted tagline principle. Principles were endorsed at retreat fall 2022 immediate implementation.•Communicate disparities research◦The support reviews help address long-standing health an actionable way.•Embrace diverse perspectives◦The bring perspectives interpretation strengthen breadth depth science impact journal.•Boost accessibility◦The career development researchers historically marginalized underrepresented groups exposure wide current science, promote participation process, encourage greater opportunities collaboration, likelihood academic professional success.•Practice purposeful action◦With intention, flexibility, humility, engage DEI practices dismantling structural racism inequality publishing.CEBP integrated Communicate, Embrace, Boost, Practice into do. Editorial Board 2023 2024 Annual Meeting reflection this annually spring meeting. To implement action, convened two subcommittees, international-focused US-focused, recommend actions. asked them prioritize implementation near- versus long-term, feasibility. Strategies near-term priorities developed prioritized increasing diversity, global, board, reviewer training program early-stage investigators, backgrounds.We welcome most recent Jonine Figueroa, Caitlin Murphy, Camille Ragin! They join Smita Bhatia, Talía Malagón, Hazel Nichols, Mark Purdue, Anne Zeleniuch-Jacquotte, who service update. Samuel O. Antwi, Iona Cheng, Sophia George, Theresa Hastert, Martin Lajous, Lauren McCullough, Jessica Petrick, Aesun Shin, Melissa A. Simon, Gideon St. Helen, Lang Wu, Yelena Wu board. eternally grateful board members completed last update.In reviewers typically identified through knowledge personal networks. strategy did not necessarily broad perspective equitable selection. critical point because expecting respond variety potentially enhances research. Equally important benefit investigators: Serving learning opportunity promoting (promotions committees look CVs indication being viewed expert). Dr. Jing Peng, associate heard new investigators events (roundtable Becoming Effective Peer Reviewer: Improving Quality Articles Cultivating Career Development) obvious how become reviewer, they served, had idea whether critique provided target useful authors.Thus, excited Review Training Program, which announced Meeting. aims early scientists providing live manuscript experienced leaders Early around globe invited April cohort. Selected participants automatically entered pool, those performance evaluations beyond program. Each year applications solicited. See information page, linked above, additional program, watch next round 2025.Consistent Scope Principles, publishes rigorous conducted populations geographies. Recently, submissions report already well-recognized associations studied meet expectation innovation, such should provide solid rationale why association needs again (e.g., higher lower background incidence population, potential interaction exposures unique geography) put findings context what known. seen uptick pressing local evaluated small studies. These better suited regional journals.CEBP showcases strives utility ways. within issue.•Highlights. issue, suggestions rigor, impact, select four attention readers. balance highlights scope areas. Highlights posted webpage particular under "Issue Sections."•In Spotlight commentaries. increased number pieces reflect found particularly noteworthy.•Traditional media. Communications identifies interest general audiences irrespective communicates press releases, Research Catalyst, via media outlets like LinkedIn.•Editors' picks. month, releases editors' "must read" selections journal, CEBP.•Award. recognize "major fields represented Journal's area" Frederick P. Li Impact Award. Recipients reception. Congratulations recipient, Angela Mariotto colleagues, "Medical Care Costs Associated Survivorship United States" (1).•Dynamic collections. 2020, introduced "Dynamic Collections," compilations recently thematically related curated editors. continually add themes, cover contemporary cancer-relevant populations, "Epidemiology Aging Cancer" "Cancer Epidemiology Asian American Pacific Islander Populations." E-collections dynamic; theme regularly.•Resource reports. provides "descriptions major data resources cohorts, consortia, networks, researchers. practical application resource must clearly described." An online collection forthcoming, but using search feature site.•Cancer progress priorities. articles, authored national international experts, statistics, trends, risk factors, gaps knowledge. Recent installments included breast (2), thyroid (3), gastric (4). installment, liver cancer, process. convenient cite grant applications. one prostate (5) advance reading lecture colleague's epidemiology course.•AACR Disparities Progress Report 2024: Achieving Bold Vision Health Equity. commentary highlighting read! (6).I pondering even guide fulfilling tagline. appropriate, urge consider implementing strategies "Translating Science Populations."Coordinate policy-makers generate needed evidence. promoted policy-informing (AACR AM offprint; Dynamic Collection), mentioned documents. But, if evidence need. call coordination conduct inform policy-making near term.Coordinate basic "back translation" causation. 30 years, sciences, often epidemiology, focus discovery biomarkers outcomes, (Cancer Prevention's issue November 1991). With emerging technologies, efforts NCI fully 'omics era consortium-based validation sets. studies observational biases, chance always possible explanation, despite large size dealing false rates. Furthermore, lots "validated" that's where inquiry ends…no "Translation Populations."To realize translation, bridge assess causation determine underlying mechanisms experiment. supported, forward evaluate optimal interventions, individual societal policy), best them.I find handoff smooth cohort samples investigate laboratory observed study population. What certainly systematic laboratory. see following barriers:•No term purpose generating experimental mechanism.•No handoff. How effective connections handoff?•No discoveries mechanism.◦When worth effort cost?◦What criteria, evidence, back translation?◦Do wait consortium finding confirmed set, mechanism unclear?◦How big warrant handoff?◦Should substantiated identified?•No funding uncover mechanism. De novo experiments designed specifically expensive.◦In my experience, funders discourage include both animal models discipline "might get it."There considerations translation:•How worsen disparities? occur handed off systematically cohorts consortia long follow-up, tend US- Europe-based cohorts.•How laboratory-based cell lines animals) appropriate natural history acting model actually informs mechanism?•If uncovered, efficiently closer translation?I low-cost lead:•Develop exciting name explicit term, relevant.•For CEBP, prepare case successful handoffs argue strategy, educate scientists, spark strategy.•Using content, direction flow especially same application.•Encourage conference chairs discussions directions.On lighter side, wondered art comes from? identify figures amenable artful adaptation guided Pavlovcak (so talents!). Jing, Greg, weigh feel month's issue. three Mid-Atlantic region, colors imagery match season July captures peak summer sun heat). derived referenced, key described issue's link "Cover Image." Please encouragement color (there fees color) readability your work. Your adapted cover!I re-read "An Update Editor-in-Chief" (7) outlined journal. happy achieved thanks users, reviewers, Journals!E.A. Platz study, elected member directors AACR.
Язык: Английский
Процитировано
0