Unravelling the Regulatory Roles of lncRNAs in Melanoma: From Mechanistic Insights to Target Selection

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2126 - 2126

Опубликована: Фев. 27, 2025

Melanoma is the deadliest form of skin cancer, and its treatment poses significant challenges due to aggressive nature resistance conventional therapies. Long non-coding RNAs (lncRNAs) represent a new frontier in search for suitable targets control melanoma progression invasiveness. Indeed, lncRNAs exploit wide range regulatory functions along chromatin remodeling, gene transcription, post-transcription, transduction, post-transduction ultimately tune multiple cellular processes. The understanding this intricate flexible network orchestrated by pathological conditions can strategically support rational identification promising targets, speeding up setup therapeutics integrate currently available approaches. Here, most recent findings on involved will be analyzed. In particular, functional links between their mechanisms action some frequently underestimated features, like different subcellular localizations, highlighted.

Язык: Английский

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Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

Advanced Science, Год журнала: 2024, Номер 11(44)

Опубликована: Окт. 8, 2024

Abstract RNA‐modifying proteins, classified as “writers,” “erasers,” and “readers,” dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing stability, functionality, interactions. To date, over 170 distinct modifications more than 100 enzymes have been identified, with ongoing research expanding these numbers. Although significant progress has made in understanding modification, the regulatory mechanisms that govern proteins themselves remain insufficiently explored. Post‐translational (PTMs) such phosphorylation, ubiquitination, acetylation are crucial modulating function behavior of proteins. However, full extent PTM influence on their role disease development remains to be fully elucidated. This review addresses gaps offering a comprehensive analysis roles PTMs play regulating Mechanistic insights provided into how alter biological processes, contribute cellular function, drive progression. In addition, current landscape is examined, highlighting therapeutic potential targeting for precision medicine. By advancing networks, this seeks facilitate effective strategies inspire future critical area

Язык: Английский

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Molecular Mechanisms and Therapeutic Implications of Long Non‐coding RNAs in Cutaneous Biology and Disease

Journal of Cellular Physiology, Год журнала: 2025, Номер 240(2)

Опубликована: Фев. 1, 2025

ABSTRACT Human skin is the largest organ of human body and accounts for approximately fifteen percent total bodyweight. Its main physiological role to protect against a wide range environmental factors including pathogens, ultraviolet light, injury. Importantly, can regenerate heal upon injury in large part by differentiation keratinocytes. Not surprisingly, dysregulation cutaneous self‐renewal result variety skin‐related pathologies, autoimmune disease cancer. Increasing evidence supports premise that long non‐coding RNAs (lncRNAs) act as critical mediators gene expression regulate important biological processes within skin. Notably, lncRNAs has been shown influence diverse pathological consequences. More recently, numerous reports have revealed new mechanistic insight on play homeostasis well their contribution pathogenesis disorders. Here, we review functions impact homeostasis. We also describe fundamental roles disorders, fibrotic, autoimmune, malignant diseases. Lastly, will highlight how better understanding at molecular level may reveal novel therapeutic approaches improvement

Язык: Английский

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Recent Advances in the Mutual Regulation of m6A Modification and Non-Coding RNAs in Atherosclerosis

International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 1047 - 1073

Опубликована: Фев. 1, 2025

Atherosclerosis, a progressive inflammatory disease of the arteries, remains leading cause cardiovascular morbidity and mortality worldwide. Recent years have witnessed pivotal role N6-methyladenosine (m6A) RNA methylation in regulating various biological processes, including those implicated atherosclerosis. Current evidence suggested that m6A regulators (writers, erasers, readers) participated modification multiple non-coding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), thereby affecting their metabolism functions. Meanwhile, ncRNAs also emerged as key modulator expression turn. Therefore, understanding mutual regulation between modifications is great significance to identify novel therapeutic targets for atherosclerosis has clinical application prospects. This review aims summarize recent advances reciprocal provide insights into interaction context

Язык: Английский

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KLF12 transcriptional activation by a novel LncRNA A930015D03Rik enhances melanoma metastasis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 142686 - 142686

Опубликована: Апрель 4, 2025

Язык: Английский

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