Clonal haematopoiesis and ionizing radiation: risks for hematological malignancies and somatic diseases DOI
Anastasiia Zherniakova, О. Б. Крысюк, Евгений Олегович Куневич

и другие.

Опубликована: Ноя. 6, 2024

Introduction . The influence of radiation-induced genetic instability on the formation clonal expansion is a relevant problem in health monitoring and preventive diagnostics oncohematological somatic pathology individuals exposed to long-term low-dose anthropogenic irradiation, such as nuclear industry workers radiation doctors. Objective Identification possible application points genome markers hematopoiesis groups irradiation. Results discussion Genetic genes epigenetic regulation ( DNMT3A, TET2, ASXL1 ), signaling pathways cell proliferation JAK2, FLT3 DNA repair regulators TP53, PPM1D RNA splicing factors SF3B1, SRSF2 ) most often initiates hematopoiesis, which realized more frequently by myeloid less lymphoid neoplasia. development diseases mediated combined effect carrying these mutations processes chronic inflammation. Low-dose ionizing capable initiating mainly due DNMT3A TET2 genes. There lack studies assessment increased morbidity against background occupational risk exposure (workers doctors diagnostics), requires further study. Conclusions Studies aimed at identifying growth setting action form basis for developing cohort-oriented programs disease prevention individuals.

Язык: Английский

Prognostic impact of TET2 mutations in patients with acute myeloid leukemia: HM-SCREEN-Japan 01 and 02 study DOI Creative Commons
Satoshi Iyama, SungGi Chi, Masashi Idogawa

и другие.

Annals of Hematology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Ten-eleven translocation-2 (TET2) gene mutations are observed in 12–20% of adult patients with acute myeloid leukemia (AML). The prognostic impact TET2 AML and myelodysplastic syndromes has been reported several studies; however, their results remain controversial. Therefore, we aimed to analyze the prevalence significance AML. Data were obtained from 331 according Hematologic Malignancies-SCREEN-Japan 01 02 studies, which prospective multicenter genomic profiling analyses. We found a distinct type mutations, particularly detrimental prognosis patients. Thirty-five 'significant' identified (26 frameshift nine nonsense mutations). proportion was 31.7% (10.6% 21.1% significant non-significant mutation groups). group had shorter OS than or wild-type (median: 15.9 vs. 35.0 25.9 months). Regarding response chemotherapy status, complete (CR) CR incomplete count recovery rate 37.1% 46.6% group. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) improved patient group; allo-HSCT did not affect This study indicates that certain may have effects.

Язык: Английский

Процитировано

0
The phenomenon of clonal hematopoiesis: etiology, classification and its prognostic role DOI Creative Commons
Евгений Олегович Куневич, Mariia Mikhaleva, О. Б. Крысюк

и другие.

Oncohematology, Год журнала: 2025, Номер 20(1), С. 28 - 54

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

0
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis DOI
Christopher Maximilian Arends, Siddhartha Jaiswal

Cancer Discovery, Год журнала: 2024, Номер 14(9), С. 1581 - 1583

Опубликована: Сен. 3, 2024

Summary: There is no general consensus on the set of mutations capable driving age-related clonal expansions in hematopoietic stem cells known as hematopoiesis, and current variant classifications typically rely rules derived from expert knowledge. In this issue Cancer Discovery, Damajo colleagues trained validated machine learning models without prior knowledge hematopoiesis driver to classify somatic blood for 12 genes a purely data-driven way. See related article by Demajo et al., p. 1717 (9).

Язык: Английский

Процитировано

1
Clonal haematopoiesis and ionizing radiation: risks for hematological malignancies and somatic diseases DOI
Anastasiia Zherniakova, О. Б. Крысюк, Евгений Олегович Куневич

и другие.

Опубликована: Ноя. 6, 2024

Introduction . The influence of radiation-induced genetic instability on the formation clonal expansion is a relevant problem in health monitoring and preventive diagnostics oncohematological somatic pathology individuals exposed to long-term low-dose anthropogenic irradiation, such as nuclear industry workers radiation doctors. Objective Identification possible application points genome markers hematopoiesis groups irradiation. Results discussion Genetic genes epigenetic regulation ( DNMT3A, TET2, ASXL1 ), signaling pathways cell proliferation JAK2, FLT3 DNA repair regulators TP53, PPM1D RNA splicing factors SF3B1, SRSF2 ) most often initiates hematopoiesis, which realized more frequently by myeloid less lymphoid neoplasia. development diseases mediated combined effect carrying these mutations processes chronic inflammation. Low-dose ionizing capable initiating mainly due DNMT3A TET2 genes. There lack studies assessment increased morbidity against background occupational risk exposure (workers doctors diagnostics), requires further study. Conclusions Studies aimed at identifying growth setting action form basis for developing cohort-oriented programs disease prevention individuals.

Язык: Английский

Процитировано

0