Effects of tumor treating fields (TTFields) on human mesenchymal stromal cells DOI Creative Commons
Maren Strack,

Jan Kückelhaus,

Martin Diebold

и другие.

Journal of Neuro-Oncology, Год журнала: 2024, Номер 169(2), С. 329 - 340

Опубликована: Июнь 20, 2024

Abstract Purpose Mesenchymal stromal cells (MSCs) within the glioblastoma microenvironment have been shown to promote tumor progression. Tumor Treating Fields (TTFields) are alternating electric fields with low intensity and intermediate frequency that exhibit anti-tumorigenic effects. While effects of TTFields on studied previously, nothing is known about influence MSCs. Methods Single-cell RNA sequencing immunofluorescence staining were employed identify glioblastoma-associated MSCs in patient samples. Proliferation clonogenic survival human bone marrow-derived assessed after vitro. MSC’ characteristic surface marker expression was determined using flow cytometry, while multi-lineage differentiation potential examined immunohistochemistry. Apoptosis quantified based caspase-3 annexin-V/7-AAD levels senescence ß-galactosidase staining. MSCs’ migratory evaluated Boyden chamber assays. Results showed presence significantly reduced proliferation by up 60% 90%, respectively. capacity intact TTFields, treatment resulted increased apoptosis senescence. Furthermore, capacity. Conclusion We could demonstrate tumor-associated patients, providing a rationale study impact considerably increase MSCs, resulting impaired migration. The results provide basis for further analyses role patients receiving TTFields.

Язык: Английский

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy DOI Creative Commons

Fan Guan,

Xiaomin Wu,

Jiatong Zhou

и другие.

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Май 21, 2024

A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during process of tumorigenesis, even in presence abundant oxygen, shifting main pathway energy metabolism from tricarboxylic acid cycle to aerobic glycolysis. Recent studies have unveiled dynamic transfer mitochondria within tumor microenvironment, not only between but also and stromal cells, immune others. In this review, we explore pathways mechanisms mitochondrial as well how these activities promote aggressiveness, chemotherapy resistance, evasion. Further, discuss research progress potential clinical significance targeting phenomena. We highlight therapeutic intercellular a future anti-cancer strategy enhancing cell-mediated immunotherapy.

Язык: Английский

Процитировано

20
The evolutionary theory of cancer: challenges and potential solutions DOI
Lucie Laplane, Carlo C. Maley

Nature reviews. Cancer, Год журнала: 2024, Номер 24(10), С. 718 - 733

Опубликована: Сен. 10, 2024

Язык: Английский

Процитировано

15
Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives DOI Open Access
Sílvia Fernandes, Mariana Vieira, Cristina Prudêncio

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2108 - 2108

Опубликована: Фев. 9, 2024

Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well chemical synthesis microbial biotransformation. has been investigated for its potential therapeutic properties, and exhibits anti-inflammatory, antiviral, antimalarial, antioxidant activities. Notably, ability to cross the blood-brain barrier addresses significant challenge in treating neurological pathologies. This review aims compile information about impact of betulinic an antitumor agent, particularly context glioblastoma. Importantly, demonstrates selective activity against glioblastoma cells by inhibiting proliferation inducing apoptosis, consistent with observations other cancer types. Compelling evidence published highlights acid's action suppressing Akt/NFκB-p65 signaling cascade enhancing cytotoxic effects chemotherapeutic agent temozolomide. Interesting findings also suggest focus on researching reduction glioblastoma's invasiveness aggressiveness profile. involves modulation extracellular matrix components, remodeling cytoskeleton, secretion proteolytic proteins. Drawing comprehensive review, we conclude formulations nanoparticles and/or ionic liquids are promising drug delivery approaches translation into clinical applications treatment management

Язык: Английский

Процитировано

13
The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties DOI Open Access
Sonia Gavasso, Torbjørn Kråkenes,

Håkon Olsen

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1365 - 1365

Опубликована: Янв. 23, 2024

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within central nervous system (CNS) and promote remyelination regeneration. Mesenchymal stem cells (MSCs) represent promising therapeutic option, as they have been shown migrate site of CNS injury exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, endogenous neural cell stimulation. This review summarizes current understanding underlying mechanisms discusses translation MSC transplantation their derivatives from pre-clinical demyelinating models clinical trials MS patients.

Язык: Английский

Процитировано

11
Exercise-induced extracellular vesicles in reprogramming energy metabolism in cancer DOI Creative Commons
Marju Puurand,

Alicia Llorente,

Aija Linē

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 6, 2025

Cancer is caused by complex interactions between genetic, environmental, and lifestyle factors, making prevention strategies, including exercise, a promising avenue for intervention. Physical activity associated with reduced cancer incidence progression systemic anti-cancer effects, improved tumor suppression prolonged survival in preclinical models. Exercise impacts the body's nutrient balance stimulates release of several exercise-induced factors into circulation. The mechanisms how exercise modulates energy metabolism microenvironment through effects mediated, part, extracellular vesicles (EVs) are still unknown. By transferring bioactive cargo such as miRNAs, proteins metabolites, EVs may influence cells altering glycolysis oxidative phosphorylation, potentially shifting metabolic plasticity - hallmark cancer. This short review explores roles mediators to reprogram cellular exchanging information inside microenvironment, influencing immune cells, fibroblast distant cells. Considering this knowledge, further functional studies production pathways could inform more specific interventions enhance therapy improve patient outcomes.

Язык: Английский

Процитировано

1
Glioblastoma-Associated Mesenchymal Stem/Stromal Cells and Cancer-Associated Fibroblasts: Partners in Crime? DOI Open Access

Thibault Lootens,

Bart I. Roman, Christian V. Stevens

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2285 - 2285

Опубликована: Фев. 14, 2024

Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as attractive therapeutic targets in several cancer types, due to their ability enhance tumor growth and angiogenesis contribution an immunosuppressive microenvironment (TME). In glioblastoma (GB), stem (MSCs) seem be recruited the site, where they differentiate into glioblastoma-associated (GA-MSCs) under influence of TME. GA-MSCs are reported exert important protumoral functions, such promoting invasion, increasing angiogenesis, stimulating cell (GSC) proliferation stemness, mediating resistance therapy contributing Moreover, could act precursor for cancer-associated fibroblasts (CAFs), which recently identified GB. this review, we provide overview different functions exerted by CAFs current knowledge on relationship between these types. Increasing our understanding interactions signaling pathways relevant models might contribute future regimens targeting GB-associated inhibit render TME less immunosuppressive.

Язык: Английский

Процитировано

8
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile DOI Creative Commons
Audrey Burban,

Cloé Tessier,

Mathieu Larroquette

и другие.

EMBO Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

1
Diversity of Intercellular Communication Modes: A Cancer Biology Perspective DOI Creative Commons

Thanzeela Ebrahim,

Abdul Shukkur Ebrahim, Mustapha Kandouz

и другие.

Cells, Год журнала: 2024, Номер 13(6), С. 495 - 495

Опубликована: Март 12, 2024

From the moment a cell is on path to malignant transformation, its interaction with other cells from microenvironment becomes altered. The flow of molecular information at heart cellular and systemic fate in tumors, various processes participate conveying key or certain cancer cells. For instance, loss tight junction molecules part signal sent so that they are no longer bound primary tumors thus free travel metastasize. Upon targeting single by therapeutic drug, gap junctions able communicate death by-standing discovery importance novel modes cell–cell communication such as different types extracellular vesicles tunneling nanotubes changing way scientists look these processes. However, all actively involved contexts same time recruited fulfill specific tasks? What does multiplicity mean for overall progression disease? Here, we extend an open invitation think about significance questions, rather than engage elusive attempt systematic repertory mechanisms play.

Язык: Английский

Процитировано

6
Metabolic Reprogramming in Glioblastoma Multiforme: A Review of Pathways and Therapeutic Targets DOI Creative Commons

Ashley Irin Cortes Ballen,

Maryam Amosu,

Surya Ravinder

и другие.

Cells, Год журнала: 2024, Номер 13(18), С. 1574 - 1574

Опубликована: Сен. 19, 2024

Glioblastoma (GBM) is an aggressive and highly malignant primary brain tumor characterized by rapid growth a poor prognosis for patients. Despite advancements in treatment, the median survival time GBM patients remains low. One of crucial challenges understanding treating GBMs involves its remarkable cellular heterogeneity adaptability. Central to proliferation cells their ability undergo metabolic reprogramming. Metabolic reprogramming process that allows cancer alter metabolism meet increased demands survive often oxygen- nutrient-deficient microenvironment. These changes include Warburg effect, alterations several key pathways including glutamine metabolism, fatty acid synthesis, tricarboxylic (TCA) cycle, uptake utilization glutamine, more. complexity adaptability deeper offers hope developing more effective therapeutic interventions against GBMs.

Язык: Английский

Процитировано

6
Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions DOI Creative Commons
Veronica Marabitti, Elisabetta Vulpis, Francesca Nazio

и другие.

Pharmacological Research, Год журнала: 2024, Номер 208, С. 107382 - 107382

Опубликована: Авг. 30, 2024

It is now recognized that tumors are not merely masses of transformed cells but intricately interconnected with healthy in the tumor microenvironment (TME), forming complex and heterogeneous structures. Recent studies discovered cancer can steal mitochondria from to empower themselves, while reducing functions their target organ. Mitochondrial transfer, i.e. intercellular movement mitochondria, recently emerging as a novel process biology, contributing growth, metastasis, resistance therapy by shaping metabolic landscape microenvironment. This review highlights influence transferred on bioenergetics, redox balance apoptotic resistance, which collectively foster aggressive phenotype. Furthermore, therapeutic implications mitochondrial transfer discussed, emphasizing potential targeting these pathways overcome drug improve treatment efficacy.

Язык: Английский

Процитировано

5