Living well with dementia: a systematic review and correlational meta-analysis of factors associated with quality of life, well-being and life satisfaction in people with dementia

Psychological Medicine, Год журнала: 2018, Номер 48(13), С. 2130 - 2139

Опубликована: Май 7, 2018

Abstract Current policy emphasises the importance of ‘living well’ with dementia, but there has been no comprehensive synthesis factors related to quality life (QoL), subjective well-being or satisfaction in people dementia. We examined available evidence a systematic review and meta-analysis. searched electronic databases until 7 January 2016 for observational studies investigating associated QoL, Articles had provide quantitative data include ⩾75% dementia any type severity. included 198 QoL taken from 272 articles The analysis focused on 43 sufficient data, relating 37639 Generally, these were significantly effect sizes often small (0.1–0.29) negligible (<0.09). Factors reflecting relationships, social engagement functional ability better QoL. indicative poorer physical mental health (including depression other neuropsychiatric symptoms) carer Longitudinal about predictors was limited. There considerable between-study heterogeneity. pattern numerous predominantly associations suggests need reconsider approaches understanding assessing living well

Язык: Английский

---

Drug Burden Index in older adults: theoretical and practical issues

Clinical Interventions in Aging, Год журнала: 2014, Номер unknown, С. 1503 - 1503

Опубликована: Сен. 1, 2014

Drug Burden Index in older adults: theoretical and practical issues Lisa Kouladjian,1 Danijela Gnjidic,1,2 Timothy F Chen,2 Arduino A Mangoni,3 Sarah N Hilmer1 1Sydney Medical School, University of Sydney, Kolling Institute Research Departments Clinical Pharmacology Aged Care, Royal North Shore Hospital, 2Faculty Pharmacy, NSW, 3Department Pharmacology, School Medicine, Flinders Centre, Bedford Park, SA, Australia Abstract: Anticholinergic sedative medications are commonly used adults associated with adverse clinical outcomes. The was developed to measure the cumulative exposure these its impact on physical cognitive function. This narrative review discusses research applications Index, advantages limitations, compared other pharmacologically measures high-risk prescribing. Keywords: anticholinergics, medications, prescribing, adults, pharmacological risk assessment tools, deprescribing

Язык: Английский

---

Associations of drug burden index with falls, general practitioner visits, and mortality in older people

Pharmacoepidemiology and Drug Safety, Год журнала: 2014, Номер 23(7), С. 753 - 758

Опубликована: Апрель 10, 2014

ABSTRACT Aim On a population level in people aged ≥65 years old living New Zealand, the aim of this study is to quantify each individual's cumulative exposure anticholinergic and sedative medicines using Drug Burden Index (DBI) examine impact DBI on fall‐related hospitalisations, general practitioner (GP) visits, all‐cause mortality. Method The used data extracted from Pharmaceutical Claims Data Mart (2011), National Minimum set (2012), Births, Death Marriages (2012) GP Visits for patient demographics, hospitalisations Cumulative was measured DBI. Polypharmacy defined as greater than or equal five dispensed concurrently at any time during period. Results Amongst ( n = 537 387; 45% male), 43.22% were exposed drugs (95% confidence intervals (CIs) 43.09–43.35). odds individuals with polypharmacy are 4.92 (95%CI 4.86–4.98) times that without polypharmacy. associated (incidence rate ratio (IRR) 1.56, 95%CI 1.47–1.65) number visits (IRR 1.13, 1.12–1.13). Individuals > 0 had 1.29 higher mortality risk 1.25–1.33). also hazard (HR) 1.66 1.59–1.73). Conclusion independently frequency level, may be useful quality indicator guide policy improve prescribing optimize clinical outcomes older people. Copyright © 2014 John Wiley & Sons, Ltd.

Язык: Английский

---

Anticholinergic Drug Burden Tools/Scales and Adverse Outcomes in Different Clinical Settings: A Systematic Review of Reviews

Drugs & Aging, Год журнала: 2018, Номер 35(6), С. 523 - 538

Опубликована: Май 8, 2018

Язык: Английский

---

Associations Between Polypharmacy, Symptom Burden, and Quality of Life in Patients with Advanced, Life-Limiting Illness

Journal of General Internal Medicine, Год журнала: 2019, Номер 34(4), С. 559 - 566

Опубликована: Фев. 4, 2019

Язык: Английский

---

Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review

Current Clinical Pharmacology, Год журнала: 2015, Номер 10(3), С. 178 - 184

Опубликована: Июнь 15, 2015

The aim of this systematic review was to identify, assess and summarize studies about potentially inappropriate drug use (IDU) in cognitive impairment dementia present findings whether are associated with IDU. search made Medline/PubMed using free terms the title or abstract. inclusion criteria were: English language, published until 1 March 2014, original quantitative study assessment overall IDU a consensus based summarized measure. Exclusion focus on specific patient group (other than dementia), class failure prevalence measure an effect estimate (i.e. odds ratio). Of initial 182 found Medline, 22 articles fulfilled criteria. Most used Beers for Prevalence among individuals ranged from 10.2% 56.4% higher nursing home settings community-dwelling samples. reported lower likelihood case dementia. To conclude, is highly prevalent persons dementia, although these conditions seem be probability This might reflect awareness clinicians cautious prescribing vulnerable patients. More large cohorts needed draw conclusions optimal frail older persons. Keywords: Cognitive impairment, use, review.

Язык: Английский

---

Quantification of anticholinergic and sedative drug load with the Drug Burden Index: a review of outcomes and methodological quality of studies

European Journal of Clinical Pharmacology, Год журнала: 2016, Номер 73(3), С. 257 - 266

Опубликована: Дек. 1, 2016

Язык: Английский

---

Identifying potentially inappropriate prescribing in older people with dementia: a systematic review

European Journal of Clinical Pharmacology, Год журнала: 2019, Номер 75(4), С. 467 - 481

Опубликована: Янв. 4, 2019

Older people with dementia are at risk of adverse events associated potentially inappropriate prescribing. Aim: to describe (1) how international tools designed identify prescribing have been used in studies older dementia, (2) the prevalence this cohort and (3) advantages/disadvantages Systematic literature review, reported according Preferred Reporting Items for Review Meta-Analysis Protocols (PRISMA-P). MEDLINE, EMBASE, PsychInfo, CINAHL, Cochrane Library, Social Science Citation Index, OpenGrey, Base, GreyLit, Mednar National Database Ageing Research were searched April 2016 describing use a tool or criteria dementia. Three thousand three hundred twenty-six unique papers identified; 26 included review. Eight more than one There variations applied. The Beers most commonly tool. Thirteen 15 using did not full ranged from 14 74% Benzodiazepines, hypnotics anticholinergics common inappropriately prescribed medications. Variations application may least part explain across studies. Recommendations include standardised usage ensuring comprehensive enough all medications kept up date.

Язык: Английский

---

Global prevalence of polypharmacy and potentially inappropriate medication in older patients with dementia: a systematic review and meta-analysis

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Авг. 24, 2023

Background: Older patients with dementia always need multiple drugs due to comorbidities and cognitive impairment, further complicating drug treatment increasing the risk of potentially inappropriate medication. The objective our study is estimate global prevalence polypharmacy medication (PIM) explore factors PIM for older dementia. Methods: We searched PubMed, Embase (Ovid), Web Science databases identify eligible studies from inception 16 June 2023. conducted a meta-analysis observational reporting in using random-effect model. associated were meta-analyzed. Results: Overall, 62 included, which 53 reported 28 polypharmacy. pooled was 43% (95% CI 38–48) 62% 52–71), respectively. Sixteen referred use, 15 pooled. Polypharmacy (2.83, 95% 1.80–4.44), diabetes (1.31, 1.04–1.65), heart failure (1.17, 1.00–1.37), depression (1.45, 1.14–1.88), history cancer (1.20, 1.09–1.32), hypertension (1.46, 1.05–2.03), ischemic disease (1.55, 0.77–3.12), any cardiovascular (1.11, 1.06–1.17), vascular (1.09, 1.03–1.16), chronic obstructive pulmonary (1.39, 1.13–1.72), psychosis (1.91, 1.04–3.53) are positively use. Conclusion: highly prevalent Among different regions, use varied widely. Increasing closely For other such as diabetes, prescribing should be cautioned.

Язык: Английский

---

Different methods, different results—how do available methods link a patient’s anticholinergic load with adverse outcomes?

European Journal of Clinical Pharmacology, Год журнала: 2015, Номер 71(11), С. 1299 - 1314

Опубликована: Сен. 7, 2015

Язык: Английский

---