Risk of falls or fall-related injuries associated with potentially inappropriate medication use among older adults with dementia DOI Creative Commons

Arum Moon,

Suhyun Jang,

Jung‐Ha Kim

и другие.

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 23, 2024

Potentially inappropriate medications (PIMs) are prevalent in older adults with dementia and subsequent falls or fall-related injuries. The present study determined the risk of injuries associated PIM use dementia. National Health Insurance Service-Elderly Cohort Database 2.0 (NHIS-ECDB 2.0) was used for this self-controlled case series (SCCS) study. This included 1430 participants who went through exposure non-exposure periods application among patients experienced outcome events between January 2016 December 2019. incidence during post-exposure compared that period. Beers Criteria were to define PIMs Negative binomial regression conducted. rate ratio (IRR) determine During which occurred, mean number 3.76 (SD = 2.99), most commonly first-generation antihistamines (n 283; 59.1%). Compared period, adjusted IRR period 1.57 (95% CI 1.39–1.76). increased when initiated (1–14 days: 2.76, 95% 2.31–3.28; 15–28 1.95, 1.48–2.56; ≥ 29 1.17, 1.01–1.35). Especially, an greater Among dementia, significantly increase Therefore, strategies should be developed manage prescriptions prevent falls.

Язык: Английский

The Impact of Pharmacist Interventions on Quality Use of Medicines, Quality of Life, and Health Outcomes in People with Dementia and/or Cognitive Impairment: A Systematic Review DOI
Tuan Anh Nguyen, Julia Gilmartin‐Thomas, Edwin C.K. Tan

и другие.

Journal of Alzheimer s Disease, Год журнала: 2019, Номер 71(1), С. 83 - 96

Опубликована: Июль 22, 2019

Medication use in people with dementia and/or cognitive impairment (PWD/CI) is challenging. As medication experts, pharmacists have an important role improving care of this vulnerable population. Systematically review evidence for the effectiveness pharmacist-led interventions on quality medicines, life, and health outcomes PWD/CI. A systematic was conducted using MEDLINE, EMBASE, PsycINFO, Allied Complementary Medicine (AMED) Cumulative index to Nursing Health Literature (CINAHL) databases from conception 20 March 2017. Full articles published English were included. Data synthesized a narrative approach. Nine studies eligible inclusion. All high-income countries assessed management services. There great variability content focus services described reported. Pharmacists found provide number including reconciliation, review, adherence These generally effective regards medicines PWD/CI their caregivers, saving costs healthcare system. Pharmacist-led consultation may also improve caregiver understanding different aspects pharmacotherapy, thus adherence. Emerging suggests that outcomes. Future research should confirm these findings more robust study designs explore additional roles could undertake pursuit supporting

Язык: Английский

Процитировано

29
Burden of Potentially Harmful Medications and the Association With Quality of Life and Mortality Among Institutionalized Older People DOI
Anna-Liisa Juola,

S. Pylkkanen,

Hannu Kautiainen

и другие.

Journal of the American Medical Directors Association, Год журнала: 2016, Номер 17(3), С. 276.e9 - 276.e14

Опубликована: Янв. 22, 2016

Язык: Английский

Процитировано

27
Medication Monitoring for People with Dementia in Care Homes: The Feasibility and Clinical Impact of Nurse-Led Monitoring DOI Creative Commons
Sue Jordan,

Marie Gabe,

Louise Newson

и другие.

The Scientific World JOURNAL, Год журнала: 2014, Номер 2014, С. 1 - 11

Опубликована: Янв. 1, 2014

Objectives . People with dementia are susceptible to adverse effects of medicines. However, they not always closely monitored. We explored (1) feasibility and (2) clinical impact nurse-led medication monitoring. Design Feasibility “before-and-after” intervention study. Setting Three care homes in Wales. Participants Eleven service users diagnosed dementia, taking at least one antipsychotic, antidepressant, or antiepileptic medicine. Intervention West Wales Adverse Drug Reaction (ADR) Profile for Mental Health Medicines. Outcome Measures Feasibility: recruitment, retention, implementation. Clinical impact: previously undocumented problems identified ameliorated, as recorded participants’ records before after introduction the profile, month later. Results Nurses recruited retained 11 29 eligible users. The profile took 20–25 minutes implement, caused no harm, supplemented usual care. Initially, all participants (mean 12.7 (SD 4.7)). One later, some had been ameliorated 4.9 (3.6)). gains included new prescriptions manage pain (2 participants), psoriasis (1), Parkinsonian symptoms rash dose reduction benzodiazepines plans oral hygiene, skin problems, constipation. Conclusions benefited from structured trials our ADR feasible necessary.

Язык: Английский

Процитировано

27
Validation of the Spanish Version of the ICECAP-O for Nursing Home Residents with Dementia DOI Creative Commons
Carmen Sarabia‐Cobo, Paula Parás‐Bravo, Francisco José Amo-Setién

и другие.

PLoS ONE, Год журнала: 2017, Номер 12(1), С. e0169354 - e0169354

Опубликована: Янв. 9, 2017

Background Measurement of health-related quality life (HRQoL) is important for a chronic disease, such as dementia, which impairs the affected patients in addition to their length life. This context economic evaluations when interventions do not (only) affect HRQoL and these other factors also overall Objective To validate Spanish translation ICECAP-O's capability measure Health-related elderly with dementia who live nursing homes. Method Cross-sectional study. For 217 residents living 8 homes, questionnaires were completed by professionals serving proxy respondents. We analyzed internal consistency psychometric properties. investigated convergent validity ICECAP-O instruments, EQ-5D extended cognitive dimension (EQ-5D+C), Alzheimer's Disease Related Quality Life (ADRQL) measures, Barthel Index activities daily (ADL). Results The presents satisfactory (alpha 0.820). factorial analysis indicated structure five principal dimensions that explain 66.57% total variance. Convergent between ICECAP-O, EQ-5D+C, ADRQL, scores was moderate good (with correlations 0.62, 0.61, 0.68, respectively), but differed instruments. Discriminant confirmed finding differences subgroups based on ADL (0.70 low, 0.59 medium, 0.39 high level care), severity (0.72 mild, 0.63 0.50 severe), ages (0.59 below 75 years 0.84 above years). Conclusions study presented first use version ICECAP-O. results indicate appears be reliable measurement instrument showing discriminant people dementia.

Язык: Английский

Процитировано

25
Risk of falls or fall-related injuries associated with potentially inappropriate medication use among older adults with dementia DOI Creative Commons

Arum Moon,

Suhyun Jang,

Jung‐Ha Kim

и другие.

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 23, 2024

Potentially inappropriate medications (PIMs) are prevalent in older adults with dementia and subsequent falls or fall-related injuries. The present study determined the risk of injuries associated PIM use dementia. National Health Insurance Service-Elderly Cohort Database 2.0 (NHIS-ECDB 2.0) was used for this self-controlled case series (SCCS) study. This included 1430 participants who went through exposure non-exposure periods application among patients experienced outcome events between January 2016 December 2019. incidence during post-exposure compared that period. Beers Criteria were to define PIMs Negative binomial regression conducted. rate ratio (IRR) determine During which occurred, mean number 3.76 (SD = 2.99), most commonly first-generation antihistamines (n 283; 59.1%). Compared period, adjusted IRR period 1.57 (95% CI 1.39–1.76). increased when initiated (1–14 days: 2.76, 95% 2.31–3.28; 15–28 1.95, 1.48–2.56; ≥ 29 1.17, 1.01–1.35). Especially, an greater Among dementia, significantly increase Therefore, strategies should be developed manage prescriptions prevent falls.

Язык: Английский

Процитировано

2