Clinical & Experimental Allergy,
Год журнала:
2023,
Номер
53(11), С. 1147 - 1161
Опубликована: Авг. 28, 2023
Abstract
Suppressor
of
cytokine
signalling
(SOCS)
proteins
bind
to
certain
receptors,
Janus
kinases
and
molecules
regulate
pathways,
thus
controlling
immune
inflammatory
responses.
Dysregulated
expression
various
types
SOCS
was
indicated
in
multiple
allergic
diseases.
SOCS1,
SOCS2,
SOCS3,
SOCS5,
cytokine‐inducible
SH2
domain
protein
(CISH)
can
differentially
exert
anti‐allergic
impacts
through
different
mechanisms,
such
as
suppressing
Th2
cell
development
activation,
reducing
eosinophilia,
decreasing
IgE
production,
repressing
production
pro‐allergic
chemokines,
promoting
Treg
differentiation
Th17
increasing
Th1
responses,
inhibiting
M2
macrophage
polarization,
modulating
survival
mast
cells,
activity
keratinocytes,
pulmonary
fibrosis.
Although
some
effects
were
attributed
it
perform
several
supporting
boosting
eosinophils,
enhancing
the
chemokine
receptor,
differentiation,
Th9
well
mucus
secretion
collagen
deposition.
In
this
review,
we
discuss
contrasting
roles
contexts
disorders
provide
new
insights
regarding
pathophysiology
these
diseases
possibly
explore
potential
therapeutic
targets
for
alleviating
allergies.
Medical Principles and Practice,
Год журнала:
2022,
Номер
31(6), С. 501 - 515
Опубликована: Янв. 1, 2022
IgE-mediated
type
I
hypersensitivity
reactions
have
many
reported
beneficial
functions
in
immune
defense
against
parasites,
venoms,
toxins,
etc.
However,
they
are
best
known
for
their
role
allergies,
currently
affecting
almost
one
third
of
the
population
worldwide.
allergic
diseases
result
from
a
maladaptive
2
response
that
promotes
synthesis
IgE
antibodies
directed
at
special
class
antigens
called
allergens.
bind
to
high-affinity
receptors
(FcεRI)
on
mast
cells
and
basophils,
sensitizing
them
get
triggered
subsequent
encounter
with
cognate
allergen.
This
release
large
variety
inflammatory
mediators
including
histamine
responsible
symptoms
immediate
hypersensitivity.
The
development
2-driven
allergies
is
dependent
complex
interplay
genetic
environmental
factors
barrier
surfaces
host
microbiome
builds
up
during
early
life.
While
undoubtedly
origin
majority
it
has
become
clear
similar
responses
can
be
by
other
types
adaptive
mediated
via
IgG
or
complement
involving
mediators.
Likewise,
various
nonadaptive
innate
triggers
expressed
been
found
either
directly
launch
reaction
and/or
amplify
existing
responses.
review
summarizes
recent
findings
both
IgE-dependent
IgE-independent
mechanisms
hypersensitivities
provides
an
update
diagnosis
allergy.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 927 - 927
Опубликована: Янв. 23, 2025
Although
mast
cells
have
long
been
known,
they
are
not
yet
fully
understood.
They
traditionally
recognized
for
their
role
in
allergic
reactions
through
the
IgE/FcεRI
axis,
but
different
groups
of
surface
receptors
since
characterized,
which
appear
to
be
involved
manifestation
peculiar
clinical
features.
In
particular,
MRGPRX2
has
emerged
as
a
crucial
receptor
degranulating
human
skin
cells.
Because
cells’
close
proximity
peripheral
nerve
endings,
it
may
play
key
neuroimmune
interactions.
This
paper
provides
an
overview
cell
contributions
hypersensitivity
and
so-called
“pseudoallergic”
reactions,
well
update
on
neuroinflammatory
implications
main
models
airway
diseases.
cellular
characteristics
most
relevant
MC
pathophysiology
reappraised
light
recent
advancements
research.
Molecular
aspects
related
degranulation
induced
by
IgE
or
analyzed
compared,
along
with
possible
repercussions
limitations
future
therapeutic
perspectives.
Mechanobiology in Medicine,
Год журнала:
2024,
Номер
2(1), С. 100041 - 100041
Опубликована: Фев. 1, 2024
Type
1
hypersensitivity
involves
an
exaggerated
immune
reaction
triggered
by
allergen
exposure,
leading
to
rapid
release
of
inflammatory
mediators.
Meanwhile,
mechanobiology
explores
how
physical
forces
influence
cellular
processes,
and
recent
research
underscores
its
relevance
in
allergic
reactions.
This
review
provides
a
concise
overview
hypersensitivity,
highlighting
the
pivotal
role
mast
cells
immunoglobulin
E
(IgE)
antibodies
orchestrating
Recognizing
dynamic
nature
responses
allergies,
this
study
subsequently
delves
into
emerging
field
significance
understanding
mechanical
governing
cell
behavior.
Furthermore,
molecular
during
activation
degranulation
are
explored,
elucidating
aspects
IgE
binding
cytoskeletal
rearrangements.
Next,
we
discuss
intricate
interplay
between
extracellular
matrix,
emphasizing
impact
matrix
stiffness
on
responses.
Additionally,
examine
key
mechanosensitive
signaling
pathways,
including
mitogen-activated
protein
kinase
(MAPK)
pathway,
Rho
guanosine
triphosphatase
(GTPase)
integrin-mediated
focal
adhesion
signaling,
shedding
light
their
contributions
insights
potential
therapeutic
targets
biomarkers,
paving
way
for
better
clinical
management
Pharmacological Research,
Год журнала:
2024,
Номер
204, С. 107203 - 107203
Опубликована: Май 6, 2024
Recent
research
has
demonstrated
the
immunomodulatory
potential
of
Panax
notoginseng
in
treatment
chronic
inflammatory
diseases
and
cerebral
hemorrhage,
suggesting
its
significance
clinical
practice.
Nevertheless,
complex
immune
activity
various
components
hindered
a
comprehensive
understanding
immune-regulating
properties
notoginseng,
impeding
broader
utilization.
This
review
evaluates
effect
to
types
white
blood
cells,
elucidates
underlying
mechanisms,
compares
effects
different
active
fractions,
aiming
provide
theory
basis
for
future
investigation.
Authorea (Authorea),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 22, 2024
Type
1
hypersensitivity
involves
an
exaggerated
immune
reaction
triggered
by
allergen
exposure,
leading
to
rapid
release
of
inflammatory
mediators.
Meanwhile,
mechanobiology
explores
how
physical
forces
influence
cellular
processes,
and
recent
research
underscores
its
relevance
in
allergic
reactions.
This
review
provides
a
concise
overview
hypersensitivity,
highlighting
the
pivotal
role
mast
cells
immunoglobulin
E
(IgE)
antibodies
orchestrating
Recognizing
dynamic
nature
responses
allergies,
this
study
subsequently
delves
into
emerging
field
significance
understanding
mechanical
governing
cell
behavior.
Furthermore,
molecular
during
activation
degranulation
are
explored,
elucidating
aspects
IgE
binding
cytoskeletal
rearrangements.
Next,
we
discuss
intricate
interplay
between
extracellular
matrix,
emphasizing
impact
matrix
stiffness
on
responses.
Additionally,
examine
key
mechanosensitive
signaling
pathways,
including
mitogen-activated
protein
kinase
(MAPK)
pathway,
Rho
guanosine
triphosphatase
(GTPase)
integrin-mediated
focal
adhesion
signaling,
shedding
light
their
contributions
insights
potential
therapeutic
targets
biomarkers,
paving
way
for
better
clinical
management
reactions.Keywords:
hypersensitivity;
mechanobiology;
mechanosensing;
mechanotransduction;
allergy.IntroductionType
represents
prototypical
characterized
response
innocuous
substances,
known
as
allergens.
is
classified
immediate
or
(IgE)-mediated
involving
mediators
upon
re-exposure
specific
The
sensitization
phase
begins
when
system
individuals
prone
responds
first
exposure
allergens
producing
[1,2].
These
occupy
high-affinity
receptors
surface
basophils.
Upon
subsequent
these
allergens,
crosslink
activate
basophils,
triggering
potent
such
histamine,
leukotrienes,
cytokines
(Figure
)
[1,3–5].
results
manifestations
allergy,
ranging
from
mild
symptoms
like
itching
sneezing
severe,
life-threatening
reactions
anaphylaxis
[1,6].
Common
implicated
span
broad
spectrum,
environmental
pollen,
dust
mites
animal
dander,
well
food
nuts,
shellfish
eggs.
insect
venom,
certain
medications
latex
recognized
triggers
[7].
pivotal,
perceives
them
foreign
mounts
response,
with
exposures
heightened
sensitivity
escalating
[8].
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 6913 - 6913
Опубликована: Июнь 24, 2024
Chronic
exposure
to
harmful
pollutants,
chemicals,
and
pathogens
from
the
environment
can
lead
pathological
changes
in
epithelial
barrier,
which
increase
risk
of
developing
an
allergy.
During
allergic
inflammation,
cells
send
proinflammatory
signals
group
2
innate
lymphoid
cell
(ILC2s)
eosinophils,
require
energy
resources
mediate
their
activation,
cytokine/chemokine
secretion,
mobilization
other
cells.
This
review
aims
provide
overview
metabolic
regulation
asthma,
atopic
dermatitis
(AD),
rhinitis
(AR),
highlighting
its
underlying
mechanisms
phenotypes,
potential
regulatory
roles
eosinophils
ILC2s.
Eosinophils
ILC2s
regulate
inflammation
through
lipid
mediators,
particularly
cysteinyl
leukotrienes
(CysLTs)
prostaglandins
(PGs).
Arachidonic
acid
(AA)-derived
metabolites
Sphinosine-1-phosphate
(S1P)
are
significant
markers
that
indicate
immune
dysfunction
barrier
Notably,
promoters
symptoms
exhibit
greater
plasticity
compared
ILC2s,
directly
involved
promoting
symptoms.
Our
findings
suggest
metabolomic
analysis
provides
insights
into
complex
interactions
between
cells,
environmental
factors.
Potential
therapeutic
targets
have
been
highlighted
further
understand
Future
research
metabolomics
facilitate
development
novel
diagnostics
therapeutics
for
future
application.
Allergy,
Год журнала:
2024,
Номер
79(10), С. 2625 - 2661
Опубликована: Авг. 4, 2024
Abstract
The
impact
of
human
IgE
glycosylation
on
structure,
function
and
disease
mechanisms
is
not
fully
elucidated,
heterogeneity
in
different
studies
renders
drawing
conclusions
challenging.
Previous
reviews
discussed
focusing
specific
topics
such
as
health
versus
disease,
FcεR
binding
or
function.
We
present
the
first
systematic
review
conducted
utilizing
PRISMA
guidelines.
sought
to
define
current
consensus
concerning
roles
biology
disease.
Despite
diverse
analytical
methodologies,
source,
expression
systems
sparsity
data
antibodies
from
non‐allergic
individuals,
collectively
evidence
suggests
differential
profiles,
particularly
allergic
diseases
compared
with
healthy
states,
indicates
functional
impact,
contributions
IgE‐mediated
hypersensitivities
atopic
diseases.
Beyond
diseases,
dysregulated
terminal
glycan
structures,
including
sialic
acid,
may
regulate
metabolism.
Glycan
sites
N394
contribute
stabilizing
alterations
these
glycans
likely
influencing
both
structure
IgE‐FcεR
interactions.
This
therefore
highlights
critical
attributes
that
be
exploitable
for
therapeutic
intervention,
need
novel
analytics
explore
pertinent
research
avenues.
Applied Biological Chemistry,
Год журнала:
2025,
Номер
68(1)
Опубликована: Янв. 14, 2025
Abstract
Allergy
is
an
immune-mediated
disorder
characterized
by
exaggerated
response
of
the
immune
system
to
non-hazardous
substances,
resulting
in
allergic
symptoms
such
as
rash,
itching,
and
runny
nose.
Current
therapeutic
interventions
include
antihistamines
steroids;
however,
they
induce
several
side
effects.
Although
5,7-dihydroxy-4-methylcoumarin,
a
phytochemical
derivative,
has
been
demonstrated
exhibit
antioxidant,
anti-apoptotic,
anti-aggregatory
effects,
its
anti-allergic
properties
underlying
molecular
mechanisms
remain
elusive.
Therefore,
this
study
was
conducted
investigate
effects
5,7-dihydroxy-4-methylcoumarin
two
experimental
models:
rat
basophilic
leukemia-2H3
cells
sensitized
using
dinitrophenyl-specific
immunoglobulin
E
(IgE)/human
serum
albumin
passive
cutaneous
anaphylaxis
(PCA)
murine
model.
Our
findings
that
reduced
release
histamine
β-hexosaminidase
downregulated
mRNA
expression
allergic-inflammatory
cytokines,
interleukin
(IL)-4,
IL-13,
tumor
necrosis
factor-alpha,
well
inflammatory
enzyme
cyclooxygenase-2.
Furthermore,
phosphorylation
mitogen-activated
protein
kinases
extracellular
signal-regulated
kinase
p38,
B.
In
vivo,
PCA
reaction,
evidenced
Evans
blue
dye
extravasation
IgE-mediated
local
responses.
Collectively,
these
results
suggest
holds
promise
novel
candidate
for
development
drugs.
