Decoding the language of fear: Unveiling objective and subjective indicators in rodent models through a systematic review and meta-analysis
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
157, С. 105537 - 105537
Опубликована: Янв. 11, 2024
Язык: Английский
Epigenetics of Violence Against Women: A Systematic Review of the Literature
Current Zoology,
Год журнала:
2024,
Номер
10(1)
Опубликована: Янв. 1, 2024
Violence
against
women
is
a
pervasive
global
issue
with
profound
impacts
on
victims'
well-being,
extending
across
cultural
boundaries.
Besides
immediate
physical
harm,
it
triggers
mental
health
consequences
such
as
post-traumatic
stress
disorder
(PTSD).
Indeed,
the
trauma
experienced
during
violent
event
that
can
lead
to
epigenetic
modifications,
ultimately
contributing
onset
of
PTSD.
While
research
effects
initially
focused
war
veterans
and
disaster
survivors,
there
dearth
studies
violence
women.
In
this
article,
we
performed
systematic
review
aimed
fill
gap,
examining
existing
impact
The
assessed
sample
sizes,
study
validity,
gene-specific
investigations.
Currently,
insufficient
data
for
comprehensive
meta-analysis,
highlighting
nascent
stage
in
understanding
complex
issue.
Future
crucial
deeper
insights
into
mechanisms
related
women,
improved
interventions
support
healthcare
systems
affected
individuals.
Язык: Английский
Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neurons
Опубликована: Окт. 16, 2024
Most
epigenetic
research
on
post-traumatic
stress
disorder
(PTSD)
has
primarily
focused
DNA
methylation
(5mC)
in
peripheral
tissues,
particularly
at
CpG
sites.
hydroxymethylation
(5hmC)
been
found
to
be
highly
enriched
the
mammalian
brain,
while
5mC
non-CpG
sites
shows
high
enrichment
neurons.
However,
little
is
known
about
their
role
PTSD.
Here,
we
characterize
genome-wide
differential
and
5hmC
both
postmortem
orbitofrontal
neurons
from
PTSD
cases
controls.
Utilizing
reduced-representation
oxidative
bisulfite
sequencing,
that
significant
(GWS)
CpGs
were
hyper-5mC/5hmC,
whereas
GWS
non-CpGs
hypo-5mC/5hmC.
Compared
with
5mC,
show
a
more
sensitive
mark
PTSD,
higher
number
of
stronger
significance
pathways.
Integrating
other
-omics
data
highlighted
developmental
processes
as
convergent
pathways
revealed
overlap
our
findings
50
previously
reported
PTSD-associated
genes,
including
potential
therapeutic
targets
such
CRHR1
DRD4.
This
study
underscores
importance
evaluating
human
brain
multi-omics
integration
provides
insights
into
target
genes
for
future
interventions
Graphical
abstract
The
conducted
comprehensive
analysis
modifications
25
13
healthy
It
was
observed
patients
exhibit
greater
compared
Specifically,
individuals
tend
hyper-5mC/5hmC
sites,
within
islands
promoter
regions,
hypo-5mC/5hmC
especially
intragenic
regions.
Functional
indicated
distinct
yet
interconnected
roles
marks
regulate
cell-cell
adhesion
processes,
are
involved
embryonic
morphogenesis
cell
fate
commitment.
By
integrating
published
central
tissues
through
approaches,
several
biological
mechanisms
prioritized,
HPA
axis
regulation,
immune
responses.
Based
consistent
hypothesize
if
changes
occur
during
early
stages,
they
may
increase
risk
developing
following
trauma
exposure.
Conversely,
these
adulthood,
influence
neuronal
apoptosis
survival
mechanisms.
Язык: Английский
Post-traumatic stress disorder: molecular mechanisms of the intergenerational and transgenerational inheritance
Успехи физиологических наук,
Год журнала:
2024,
Номер
55(4), С. 3 - 26
Опубликована: Дек. 8, 2024
Post-traumatic
stress
disorder
is
a
mental
that
closely
associated
with
dysfunction
of
the
hypothalamic-pituitary-adrenal
axis,
and
for
its
development
required
experience
traumatic
event
causes
negative
emotions
memories
persist
quite
long
time.
The
likelihood
post-traumatic
influenced
both
environmental
factors,
genetic
epigenetic
characteristics
body.
In
this
case
modifications
act
as
dynamic
biomarkers
(“nanotags”)
impact
environment
on
genome
(epigenome),
which
can,
under
certain
conditions,
disappear
or
remain
not
only
in
an
individual
directly
exposed
to
psychogenic
trauma,
but
also
transmitted
over
number
generations.
Review
focuses
possible
mechanisms
intergenerational
transgenerational
inheritance
biological
effects
stress-related
disorders.
Язык: Английский