Alimentary Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
We
thank
Drs
Mendoza
and
Irwin
for
the
insightful
editorial
on
our
paper
[1,
2].
Allostatic
load
(AL),
which
represents
cumulative
wear
tear
multiple
organs
tissues
resulting
from
various
stressors
throughout
life,
may
serve
as
a
pivotal
lever
to
explore
association
between
chronic
stress
development
progression
of
inflammatory
bowel
disease
(IBD)
[3].
However,
several
points
merit
further
discussion.
First,
effectively
assessing
characterising
AL
has
been
widely
discussed.
Since
concept
was
introduced,
research
linking
it
health
outcomes
surged
in
past
30
years.
there
remains
lack
consensus
regarding
assessment
characterisation
methods,
severely
limits
ability
make
comparisons
across
studies
[4].
The
system-specific
scoring
method
regarded
significant
advancement
Furthermore,
clinimetrics
extend
beyond
biomarkers
have
developed
describe
or
measure
symptoms,
physical
signs
other
clinical
phenomena
[5].
Second,
most
relies
baseline
static
measurements
biomarkers,
making
difficult
capture
dynamic
changes
over
time.
emphasises
preclinical
state;
therefore,
monitoring
allostatic
biomarker
panel
(ALBP)
time
can
more
utilise
this
information
identify
individuals
at
greater
risk
developing
specific
diseases
enable
early
intervention,
reflects
true
utility
Third,
although
five
dimensions
metabolic
syndrome
(MetS;
i.e.,
obesity,
triglycerides,
blood
pressure,
glucose
HDL-cholesterol)
are
included
ALBP
calculation,
key
difference
is
that
MetS
uses
thresholds
diagnosis,
while
relative
levels
general
population,
mainly
indicating
state
[6].
Beyond
cardiovascular
systems
MetS,
includes
sympathetic
nervous
system,
inflammatory/immune
system
renal
function,
all
linked
higher
(Figure
1A).
Finally,
lifestyle
environmental
factors
influence
AL.
conducted
supplementary
analysis
found
an
unhealthy
significantly
associated
with
elevated
A
systematic
review
supports
findings
[7].
Evidence
lifestyles
regulate
stress,
bidirectional
relationship
exists
two
[8].
Therefore,
maintaining
healthy
potentially
reduce
by
mitigating
impact
stress.
Additionally,
green
residential
environment
lower
[9],
poor
living
environment,
characterised
lead
exposure,
household
crowding,
dangerous
traffic
riskscapes,
contribute
increased
[10].
Considering
influenced
be
reduced
through
multidimensional
opportunity
prevention
intervention
related
AL,
such
IBD.
In
summary,
future
should
validate
standardised
measurement
assess
using
longitudinal
repeated
measures
data
accurately
evaluate
concerning
occurrence
investigations
health-promoting
mitigate
Jianhui
Zhao:
conceptualization,
formal
analysis,
writing
–
original
draft.
Erxu
Xue:
curation.
Zhanju
Liu:
editing,
supervision.
Xue
Li:
supervision,
editing.
authors'
declarations
personal
financial
interests
unchanged
those
article
[1].
This
Zhao
et
al
papers.
To
view
these
articles,
visit
https://doi.org/10.1111/apt.18217
https://doi.org/10.1111/apt.18325
support
study
available
corresponding
author
upon
reasonable
request.
Psychotherapy and Psychosomatics,
Год журнала:
2024,
Номер
93(2), С. 94 - 99
Опубликована: Янв. 1, 2024
Clinical
interviewing
is
the
basic
method
to
understand
how
a
person
feels
and
what
are
presenting
complaints,
obtain
medical
history,
evaluate
personal
attitudes
behavior
related
health
disease,
give
patient
information
about
diagnosis,
prognosis,
treatment,
establish
bond
between
physician
that
crucial
for
shared
decision
making
self-management.
However,
value
of
this
skill
threatened
by
time
pressures
emphasis
on
technology.
Current
care
trends
privilege
expensive
tests
procedures
tag
devoted
interaction
with
as
lacking
cost-effectiveness.
Instead,
spent
inquire
problems
life
setting
may
actually
help
avoid
further
testing,
procedures,
referrals.
Moreover,
dialogue
an
essential
instrument
increase
patient's
motivation
engage
in
healthy
behavior.
The
aim
paper
was
provide
overview
clinical
its
optimal
use
relation
style,
flow
hypothesis
domains,
modifications
according
settings
goals,
teaching.
This
review
points
primacy
process.
quality
determines
data
collected
and,
eventually,
assessment
treatment.
Thus,
deserves
more
attention
educational
training
space
encounters
than
it
currently
receiving.
Neuropsychobiology,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Янв. 14, 2025
Background:
Somatic
symptoms,
such
as
chronic
pain,
fatigue,
and
gastrointestinal
disturbances,
are
commonly
reported
in
individuals
with
a
history
of
childhood
maltreatment
(CM),
which
includes
various
forms
abuse
neglect
experienced
before
age
18.
Although
CM
is
strongly
associated
somatic
the
specific
relationships
between
subtypes
these
well
mechanisms
connecting
them,
remain
insufficiently
understood.
This
review
examines
complex
interaction
often
coexist
mental
disorders
significantly
impact
quality
life
healthcare
systems.
Summary:
frequently
mix
"explained"
"unexplained"
conditions,
personal
distress
pose
diagnostic
challenges.
has
been
linked
to
symptoms
through
neurobiological
mechanisms,
HPA
axis
dysregulation
allostatic
load,
while
theoretical
models
emphasize
roles
hyperawareness,
cultural
factors,
vulnerability
symptom
development.
However,
existing
research
fails
account
for
subtypes,
full
range
situational
leading
inconsistencies
findings.
Key
Messages:
Bridging
gaps
literature
requires
adopting
World
Health
Organization’s
subtype
definitions
ICD-11
codes
(MA00-MH2Y)
encompass
broader
spectrum
symptoms.
Employing
rigorous
methodologies,
systematic
reviews
meta-analyses,
essential
advancing
understanding.
These
approaches
can
enhance
accuracy,
support
tailored
interventions,
promote
biopsychosocial
framework
research,
ultimately
improving
patient
outcomes
alleviating
societal
burdens.
ABSTRACT
It
would
be
highly
valuable
to
possess
a
tool
for
evaluating
disease
progression
and
identifying
patients
at
risk
of
experiencing
more
severe
clinical
course
potentially
worse
outcomes.
The
concept
allostatic
load,
which
represents
the
overall
strain
on
body
from
repeated
stress
responses,
has
been
recognized
as
precursor
development
chronic
illnesses.
functions
cumulative
measure
body's
capacity
adapt
stress.
Numerous
studies
have
demonstrated
that
elevated
load
levels
are
associated
with
various
negative
health
outcomes,
both
physical
mental,
predictive
mortality
than
individual
biomarkers.
Leveraging
unique
circumstances
presented
by
COVID‐19
pandemic,
we
evaluated
different
laboratory
parameters
in
hospitalised
assess
load.
Our
results
indicated
acts
strong
predictor
prolonged
hospitalisation,
increased
ICU
days,
mortality.
This
highlights
its
efficacy
precise
gauge
biological
dysregulation
linked
response
during
progression.
Allostatic
is
easily
obtainable
provides
an
early,
cost‐effective
indication
prognosis.
Additionally,
it
potential
forecast
necessity
admission.
As
result,
this
parameter,
indicative
comprehensive
physiological
disruption
stress,
emerges
promising
prognostic
marker
patients,
extending
beyond
COVID‐19.
Issues in Mental Health Nursing,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Апрель 23, 2025
Mental
health
nursing
demands
a
dynamic,
patient-centered
approach
that
goes
beyond
crisis
intervention
and
symptom
management.
Traditional
models
like
the
Roy
Adaptation
Model
Tidal
emphasize
adaptation
recovery
but
fall
short
in
capturing
fluid,
nonlinear
nature
of
mental
health.
The
Garcia
Adaptive
Equilibrium
Theory
(GAET)
introduces
new
framework
viewing
as
continuous
balancing
process.
In
this
model,
nurses
serve
Facilitators,
identifying
points
instability
intervening
early
to
prevent
crises.Central
GAET
is
Spectrum,
which
conceptualizes
fluctuating
continuum-from
stability
severe
distress.
Unlike
traditional
psychiatric
approaches
focused
on
reactive
treatment,
incorporates
Forecasting,
proactive
assessment
strategy
integrates
subjective
tools
(scales,
narratives)
objective
data
(biomarkers,
physiologic
signs)
anticipate
deterioration.By
reframing
care
around
real-time
stabilization,
promotes
intervention,
sustained
well-being,
shift
toward
preventive,
holistic
care.
This
theory
redefines
an
active,
interdisciplinary
practice
maintaining
equilibrium
rather
than
responding
disruption-empowering
lead
stabilization
prevention.
Psychotherapy and Psychosomatics,
Год журнала:
2024,
Номер
93(4), С. 244 - 248
Опубликована: Янв. 1, 2024
A
number
of
evidence-based
psychological
and
pharmacological
treatments
for
posttraumatic
stress
disorder
(PTSD)
are
available
today
[1‒5].
However,
many
trauma
survivors
do
not
have
PTSD
alone
but
suffer
from
various
comorbidities.
Moreover,
patients'
priorities
frequently
differ
their
therapists'
therapeutic
strategies.
In
other
words,
clinical
reality
is
usually
much
more
complex
than
research
evidence
appears
to
suggest.
Thorough
training
in
trauma-focused
psychotherapy
[4]
essential,
as
knowledge
about
effective
approaches.
wisdom
may
be
important.
The
therapist
needs
skilled
listening
patient
building
up
a
mutually
trusting
relationship.
They
also
must
able
honestly
engage
shared
decision-making
while
at
the
same
time
being
straightforward
guiding
so
that
they
can
jointly
develop
consensus
regarding
steps
take
[6‒8].John
returns
work,
tired,
bit
tense
due
some
minor
stressors
he
had
experienced
office.
On
his
way
home,
buys
2
cheeseburgers.
His
fiancée,
Anna,
will
visit
join
him
dinner.
When
opening
front
door
apartment,
key
gets
stuck,
John
has
struggle
until
manages
release
lock.
Anna
there
already,
gives
her
mouthful,
accusing
having
created
problem
with
key.
He
drops
bag
burgers
on
kitchen
table
tells
going
shower
before
shower,
suddenly
sees
entering
bathroom,
gagging,
looking
strange
expression,
then
collapsing.
jumps
out,
naked
wet,
lying
ground
motionless,
lifeless.
shakes
her,
screams
no
avail.
runs
call
ambulance.
kitchen,
obviously
taken
big
bite
one
calls
ambulance
second
time,
asking
them
angrily
why
it
takes
long
come.
After
felt
eternity,
paramedics
arrive,
only
testify
Anna's
death.John
devastated.
cannot
sleep.
concentrate.
senses
an
unbearable
restlessness.
consults
family
doctor
who
puts
sick
leave.
Yet
barely
makes
through
first
days
immediate
aftermath
tragic
passing
away
what
known
"bolus
death":
burger
she
gotten
stuck
throat,
causing
vagal
reflex,
which
led
sudden
cardiovascular
arrest.Ten
after
event,
I
see
time.
complains
insomnia
extreme
inner
tension
feels
guilty
been
rescue
fiancée.
reports
frequent
flashbacks
nightmares
reexperiences
collapsing,
ultimately
away.
fulfills
diagnostic
criteria
acute
(ASD)
[9].
provide
psychoeducation
typical
responses
potentially
traumatic
events
[10‒12].
try
convey
confident,
optimistic
attitude,
suggest
early
intervention,
combined
"watchful
waiting."
We
agree
weekly
appointments
over
next
couple
weeks
(Fig.
1).John's
ASD
symptomatology
fluctuates
course
days.
line
current
guidelines
intervention
[1,
13],
apply
elements
cognitive-behavior
treatment
[14],
limited
success.
me
expert,
very
keen
learning
my
views
repercussions
how
treat
trauma-related
problems.
clearly
idealizes
extent
during
these
sessions.
address
John's
positive
transference
this
point
helps
relationship.Six
passed
since
death.
somewhat
stabilized.
acquired
set
emotion
regulation
skills
such
walk
when
distressed.
still
nightmares.
persistently
avoids
external
reminders
death,
visiting
grave
cemetery.
keeps
blaming
himself
save
life.
hypervigilant,
difficulties
concentrating,
suffers
insomnia.
addition,
moderate
major
depressive
disorder.
depressed
mood
most
experiences
great
loss
energy,
completely
worthless.Of
note,
does
feel
sad
lost
Anna.
Instead,
constantly
haunted
by
guilt
feelings.
Whenever
reminded
incident,
immediately
idea
responsible
spends
hours
ruminating:
"If
was
doctor,
could
applied
Heimlich
maneuver,
thus
rescuing
her!"
(the
maneuver
medical
emergency
procedure
relieve
foreign
body
airway
obstruction
if
timely
properly).
feelings
additionally
fueled
little
argument
upon
arrival
home:
we
argued
keys,
would
stressed
gagged
bite!".John
physical
health
issues:
high
blood
pressure,
moderately
overweight,
glucose
levels
borderline
elevated.
While
focusing
psychiatric
aspects
crisis,
am
taking
issues
into
account,
considering
psychosocial
currently
exposed
elevated
preexisting
allostatic
load
overload
[15].Now
seems
right
start
CBT.
core
include
psychoeducation,
training,
imaginal
exposure
cognitive
restructuring
[4,
12].
scared
death
treatment.
fears
"go
crazy"
were
confront
dreadful
moments
As
convince
probably
need
sessions,
categorically
refuses
even
give
try.According
international
should
refuses.
What
do?
intuitively
applying
"arm-twisting,"
might
lose
him.
Sequential
[16]
account
patient's
views.
all,
sense
(yet)
exposure.
therefore
decide
follow
preference,
change
plans
accordingly.
longer
urge
undergo
therapy.
work
persistent
insomnia,
mirtazapine
30
mg
bed.
accepts
1).I
emphasize
justified
ask
whether
(and
should)
done
something
prevent
person
present
collapsed
bathroom!
explicitly
thanks
willingness
talk
issues.
All
others
symbolically
or
literally
given
pat
back,
trying
vain
out
self-contempt.
Over
several
discuss
responsibility
using
principles
Socratic
dialog.
obsessing
Slowly
steadily,
however,
starts
getting
touch
underlying
sadness
loneliness
seem
difficult
tolerate.
17
years.
Their
relationship
seen
ups
downs.
suffered
severe
recurring
mental
went
crises;
often
impatient
grumpy
Now,
deeply
regrets
raised
"front
keys"
issue
her.
retrospect,
realizes
simply
brought
home
work.
forward
joint
dinner,
grumpily
snapped
her.Gradually,
realizing
generated
enormous
feelings:
offered
certain
illusion
control
situation.
facing
eventually
accepting
fact
nothing
done,
terrible
sequence
just
happening,
cruel
twist
fate.After
10
sessions
dialog
restructuring,
achieved
realistic
view
role
fiancée's
less
ruminating
guilt,
instead
mourning
memories
persist,
almost
vividly
event.
wakes
drenched
sweat
daily
basis.It
comes
interesting
idea:
dysfunctional
beliefs
calling
caused
unnecessary
delay
operation.
receptionist
asked
diabetes
any
cardiac
problems,
did
not.
got
angry,
yelling
send
immediately,
rather
"asking
silly
questions".
Now
wondering
somehow
get
hold
audio
recordings
two
phone
made:
recordings,
obtain
objective
information
inappropriately
actually
behaved.
entirely
convinced
thought.
Not
knowing
where
lead
us,
encourage
anyway.Interestingly,
turns
easier
expected:
brings
electronic
files
therapy
session.
too
listen
recordings.
asks
transcribed,
agree.The
following
week,
merely
transcript
distance,
trembling
sweating.
like
culprit
court
trial.
live
final
verdict.
this,
ambivalent:
expecting
"death
sentence,"
hopes
acquittal
least
mild
negotiations,
reading
him,
kind
unconventional
hardly
sit
moans,
breathing
heavily,
heart
pounding.
keep
reading.
listens
intently.
intense
pain
chest.
approach
end
call,
crying.
It
quite
regain
composure.The
recording
shows
agitated
making
call.
questions
condition.
Toward
shouted
receptionist,
turn
kept
professional
composure.
By
means
behavior
procedure.
fact,
already
place.
According
service's
files,
arrived
8
min
merciless
judge
without
evidence.John
relieved.
self-designed
session
directly
back
scene
exhausted
proud
survived
exposure!
During
reads
himself,
finally,
recording.
Again,
emotionally
involved.
third
"exposure"
session,
declares
"only
partially
guilty":
now
recognizes
upset
place
arguing
keys.
Once
all
power
life,
IT
specialist.
Sadly,
enough
her.Shortly
thereafter,
significant
intrusions.
hyperarousal
symptoms
decreased
significantly,
better
mood.
significantly
reduced
reexperiencing
symptoms.
yielded
substantial
helped
understand
biographical
origins
impact
schema
guarantee
success
link
childhood
adolescence,
particularly
father's
unpredictable
outbursts
anger
extremely
of.John
visits
grave,
crying,
mourning.
putting
apartment
order.
joins
self-help
group
people
partner.
There,
finds
whom
share
in-depth
conversations
cope
find
new
meaning
life.When
follow-up
assessment
1
year
depression.
stopped
psychotropic
medication.
resumed
goes
seeing
friends.
though.John
appointment
once
twice
year.
7
years
finally
dispose
rest
cheeseburger
keeping
deep
freezer
years.Over
now,
concerned
large
helping
"to
emotional
responses"
[17],
So
far,
good.
attitude
implicitly
conveys
problematic
message,
namely,
everything
life
controlled.
matter
bad
things
happen:
fall
ill,
loved
one,
experience
violence.
For
John,
crucial
fate.
toward
regained
intrusions,
important
learn
accept
virtually
unfolding
day
learned
distinguish
between
hand
controllable,
beyond
control,
accepted
coped
with,
along
suffering
bring
about.I
myself
lesson
well:
hard
initially
refused
insisting
started
concerns,
later
"outlandish"
retrieve
turned
better,
recovering.
grateful
taught
lesson.
played
active
design
sequential
[18].
influenced
timing
interventions
1).
properly
poorly
timed,
value.
An
mature
order
unfold
its
optimal
effect.
detailed
description
case
study,
Online
Supplementary
Material
(for
online
suppl.
material,
https://doi.org/10.1159/000538954).Good
therapists
aware
own
limitations.
tailor
individually
sequentially
[18]
each
situation,
psychopathological
status
well
resources,
[15],
resilience.
And
humbly
failures.This
article
based
example
previously
published
book
chapter
[19].The
author
conflicts
interest
declare.This
study
supported
sponsor
funder.Ulrich
Schnyder
conceived
wrote
entire
manuscript.
Psychotherapy and Psychosomatics,
Год журнала:
2024,
Номер
unknown, С. 1 - 10
Опубликована: Окт. 7, 2024
Background:
The
construct
of
“moral
injury”
is
used
widely
in
the
research
literature
and
media
to
broadly
describe
impact
events
involving
perceived
violations
one’s
sense
right
wrong
(herein
referred
as
“potentially
morally
injurious
events”
[PMIEs]).
Summary:
In
this
theoretical
review,
we
provided
a
brief
overview
its
limitations
including
lack
consensus-drawn
boundaries
operational
definitions
guide
hypothesis-driven
research.
We
discussed
whether
can
be
reliably
distinguished
from
established
psychiatric
diagnoses
psychological
constructs
inherent
challenges
separating
or
classifying
high-magnitude
stressful
life
that
likely
form
majority
PMIEs.
Assessments
purportedly
measure
are
reviewed
such
shared
measurement
variance
with
instruments.
Key
Messages:
identified
conceptual
strategies
for
investigating
behavioral
neurobiological
features
PMIEs
could
inform
field
traumatic
stress.
concluded
may
provide
an
interpretive
framework
positing
why
someone
beset
by
guilt,
shame,
and/or
rage
whereas
existing
post-traumatic
stress
disorder
depression
comprehensive
descriptions
regarding
what
might
experience
following
extremely
events.
proposed
directions
better
clarify
versus
categories
enhance
conceptualization
assessment
construct.
Psychotherapy and Psychosomatics,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Окт. 17, 2024
Diagnostic
Criteria
for
Psychosomatic
Research
(DCPR)
serve
as
an
instrument
identifying
and
classifying
specific
psychosomatic
syndromes
that
are
not
adequately
encompassed
in
standard
nosography.
The
present
study
aimed
at
measuring
the
prevalence
of
DCPR
different
clinical
settings
exploring
factors
associated
to
such
diagnoses.