Atherosclerosis and the Bidirectional Relationship Between Cancer and Cardiovascular Disease: From Bench to Bedside, Part 2 Management
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 334 - 334
Опубликована: Янв. 2, 2025
The
first
part
of
this
review
highlighted
the
evolving
landscape
atherosclerosis,
noting
emerging
cardiometabolic
risk
factors,
growing
impact
exposomes,
and
social
determinants
health.
prominent
role
atherosclerosis
in
bidirectional
relationship
between
cardiovascular
disease
cancer
was
also
discussed.
In
second
part,
we
examine
complex
interplay
multimorbid
cardio-oncologic
patients,
harmful
environments
that
lend
a
“syndemic”
nature
to
these
chronic
diseases.
We
summarize
management
strategies
targeting
disordered
factors
mitigate
explore
molecular
mechanisms
enabling
more
tailored
therapies.
Importantly,
emphasize
early
interception
through
multifactorial
interventions
detect
subclinical
signs
(via
biomarkers
imaging)
treat
modifiable
prevent
clinical
events.
A
concerted
preventive
effort—referred
by
some
as
“preventome”—is
essential
reduce
burden
atherosclerosis-driven
diseases,
shifting
from
mere
proactive
promotion
“chronic
health”.
Язык: Английский
Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment
European Journal of Clinical Investigation,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Targeting
inflammation
offers
a
unique
possibility
to
address
residual
cardiovascular
risk
in
almost
two
thirds
of
all
patients
with
prevalent
atherosclerotic
disease
(ASCVD).
However,
despite
FDA
approval
and
the
ESC
2024
Guidelines
for
Management
Chronic
Coronary
Syndrome
recommendations
implement
low-dose
colchicine
(0.5
mg
daily)
secondary
prevention
ASCVD
inflammatory
risk,
its
clinical
adoption
is
still
limited.
In
this
regard,
simple
screening
elevated
high-sensitive
C-reactive
protein
(hsCRP)
on
routine
basis
might
help
recognize
low-grade
as
an
important
therapeutic
target.
Within
present
review,
we
first
provide
recently
published
epidemiologic
evidence
that
hsCRP
at
least
strong
predictor
future
events
traditional
lipoproteins.
Furthermore,
summarize
our
recent
knowledge
currently
available
strategies
modulate
process
critically
discuss
open
issues
regarding
benefit
therapy
acute
coronary
setting
or
stroke
prevention.
addition,
also
briefly
touch
upon
some
specific
safety
related
long-term
use
colchicine.
Finally,
next
diagnostic
frontiers
targeting
such
detection
vascular/coronary
by
pericoronary
fat
attenuation
ziltivekimab,
human
monoclonal
antibody
interleukin-6.
Thus,
integration
interventions
aimed
lowering
burden
combination
aggressive
lipid-modifying
may
hold
potential
further
reduce
substantial
ASCVD.
Язык: Английский
An Attomolar-Level Optical Device for Monitoring Receptor–Analyte Interactions Without Functionalization Steps: A Case Study of Cytokine Detection
Sensors,
Год журнала:
2025,
Номер
25(3), С. 930 - 930
Опубликована: Фев. 4, 2025
A
plastic
optical
fiber
(POF)-based
device
for
biosensing
strategies
has
been
developed
to
monitor
several
protein–protein
interactions
at
ultra-low
concentrations
without
functionalization
processes,
exploiting
plasmonic
phenomena.
In
this
work,
novel
tests
were
applied
different
kinds
of
analyte–receptor
interactions,
such
as
interleukins,
where
the
bioreceptor’s
(protein
antibody)
molecular
weight
is
roughly
ten
times
that
analyte
interleukin),
while
intracellular
bioreceptors
and
small
molecules
low
have
already
demonstrated
via
same
point-of-care
test
(POCT).
The
POCT
was
implemented
by
a
white
light
source
spectrometer
connected
two
POF-based
chips
in
series:
an
innovative
microcuvette
chip
D-shaped
POF
surface
plasmon
resonance
(SPR)
probe.
particular,
achieved
drilling
three
micro
holes
core
modified
POF.
Instead
performing
step,
filled
with
specific
receptor
solution
(one
microliter
femtomolar
level),
which
selectively
captured
target
(e.g.,
cytokine)
when
samples
dropped
over
(twenty
microliters
attomolar
level).
Three
IL-1β,
IL-17A,
IL-18,
detected
range
monitoring
wavelength
shift
time
due
cytokine/antibody
(protein–protein)
interaction.
proven
be
effective
detecting
interleukins
level
few
minutes
processes.
Язык: Английский
The relationship between VAI, LAP, and depression and the mediation role of sleep duration–evidence from NHANES 2005–2020
BMC Psychiatry,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 11, 2025
The
relationship
between
obesity
and
mental
health
has
attracted
attention.
However,
large
sample
studies
on
the
visceral
fat
depression
are
lacking.
This
study
aimed
to
explore
by
using
adiposity
index
(VAI)
lipid
accumulation
product
(LAP).
Additionally,
it
sought
potential
mediating
role
of
sleep
duration
in
these
associations.
data
used
current
cross-sectional
investigation
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2005
2020,
including
19,659
participants.
Depression
was
measured
nine-item
Patient
Questionnaire.
Weighted
multivariable
regression
analysis
evaluate
correlation
VAI
LAP
with
depression.
non-linear
determined
smooth
curve
fitting
threshold
effect
analysis.
mediation
performed
investigate
duration.
stability
assessed
through
sensitivity
were
closely
related
In
fully
adjusted
model,
highest
quartile
increased
association
52%
(OR
=
1.52,
95%
CI
1.20–1.92,
P
<
0.001)
51%
1.51,
1.19–1.91,
0.001),
respectively,
compared
lowest
quartile.
Specific
saturation
effects
for
VAI,
LAP,
identified
smoothed
fitting,
inflection
points
3.81
98.55,
respectively.
revealed
that
5.1%
2.8%
associations
mediated
results
showed
interactions
hypertension
cardiovascular
disease
(P
0.05).
associated
US
adults.
non-linear,
which
may
be
highlights
as
valuable
tools
prevention
management
Язык: Английский
Fibrinogen Structural Changes and Their Potential Role in Endometriosis-Related Thrombosis
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1456 - 1456
Опубликована: Ноя. 27, 2024
Endometriosis
(EM),
a
chronic
inflammatory
condition
predominantly
affecting
women
of
reproductive
age,
has
been
linked
to
an
elevated
risk
thrombosis,
though
its
underlying
molecular
mechanisms
remain
incompletely
understood.
In
this
case-control
study,
involving
71
EM
patients
and
matched
controls,
we
explored
the
structural
functional
changes
in
fibrinogen
their
potential
role
thrombosis.
Key
oxidative
stress
markers,
such
as
reactive
oxygen
species
(ROS)
levels
blood
lymphocytes,
monocytes,
granulocytes,
along
with
plasma
lipid
peroxidation
markers
total
antioxidant
capacity,
were
measured.
Fibrinogen
structure
was
examined
using
circular
dichroism
spectroscopy
intrinsic
fluorescence,
while
properties
evaluated
by
analyzing
thrombin-mediated
polymerization
plasmin-induced
lysis.
Compared
exhibited
ROS
production
systemic
stress,
leading
notable
oxidation
alterations.
These
associated
impaired
fibrin
enhanced
resistance
lysis,
which
are
indicative
pro-thrombotic
state.
findings
suggest
that
stress-driven
modifications
may
contribute
heightened
thrombotic
EM,
highlighting
therapeutic
target
mitigate
cardiovascular
complications.
Язык: Английский