Comparative network pharmacology of artificial sweeteners to understand Its health consequences.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 29, 2024
Abstract
Background
Artificial
sweeteners
(ASwt)
are
widely
consumed
sugar
substitutes,
but
their
long-term
health
effects
remain
a
subject
of
debate.
While
regulatory
bodies
generally
consider
them
safe
at
recommended
doses,
concerns
persist
regarding
potential
adverse
effects.
This
study
aimed
to
investigate
the
interactions
between
ASwt
and
biological
targets
using
in
silico
analysis,
focusing
on
target
affinity,
selectivity,
tissue
expression.
Methods
Five
common
–
acesulfame
K
(Ac),
aspartame
(As),
sucralose
(Su),
steviol
(St),
saccharin
(Sa)
were
evaluated.
Their
predicted
cheminformatics
approach,
analysing
affinity
towards
functional
groups
protein
targets.
Concentration/affinity
(C/A)
ratios
calculated
assess
likelihood
activation
achievable
doses.
Expression
high-affinity
with
significant
C/A
various
organs
was
assessed
Human
Protein
Atlas
database.
Results
:
The
displayed
modulate
most
physiologically
feasible
affinities.
Ac
exhibited
broad
range
targets,
while
St
showed
preference
for
kinases
proteases.
Notably,
As
Su
demonstrated
membrane
receptors
kinases.
ratio
analysis
revealed
Su.
Several
its
including
ROCK2,
ACE,
ITGA2/5,
PIM2,
KDM5C,
PIM1,
SLC1A2,
SETD2,
CAPN1,
LTA4H,
MKNK2,
HDAC1
CDK,
high
ratios,
suggesting
possible
modulation
intake
levels.
Organ
specific
expression
identified
endocrine,
respiratory,
renal,
reproductive,
central
nervous,
digestive,
musculoskeletal
systems
as
region
particularly
susceptible
due
linked
cell
growth,
extracellular
matrix,
epigenetic
regulations,
inflammation.
Interestingly,
30
tissues
expressed
both
Su,
14
exclusively
As.
Conclusion
highlights
interact
some
tissue-specific
patterns
suggest
safety
that
require
vivo
validation.
Язык: Английский
Comparative Network Pharmacology of Artificial Sweeteners to Understand Its Health Consequences
Integrative Journal of Veterinary Biosciences,
Год журнала:
2024,
Номер
8(1)
Опубликована: Май 25, 2024
toxicity.Despite
safety
evaluations,
several
studies
suggest
potential
health
risks
associated
with
chronic
consumption
of
ASwt.A
WHO
systematic
review
3
revealed
that
replacement
ASwt
sugar
does
not
provide
a
means
for
weight
management
in
the
long-term,
and
have
discovered
positive
correlation
between
long
term
risk
developing
cardiovascular
disease
[5,8],
type
2
diabetes
mellitus
[6,8,11],
mortality
adults
[6,8,9,12].Current
literature
also
reveals
other
concerning
associations
various
routinely
observed
clinical
conditions,
including
heightened
cancer
[13,15],
kidney
[16,17],
adiposity
related
diseases
[8,9,18,19],
as
well
non-alcoholic
fatty
liver
[20].The
adverse
effects
following
intake
can
be
consequence
to
disruptions
insulin
signalling
gut
microbiota,
potentially
influencing
blood
control,
impacting
digestion,
nutrient
absorption,
overall
increasing
metabolic
syndrome
[21,22].Despite
these
reported
associations,
there
is
substantial
research
gap
regarding
pharmacodynamic
sweeteners
Язык: Английский
Soft drinks, fish oil and atrial fibrillation
Future Cardiology,
Год журнала:
2024,
Номер
20(15-16), С. 807 - 810
Опубликована: Ноя. 18, 2024
Keywords:
:
artificially
sweetened
soft
drinksatrial
fibrillationcohort
studyfruit
juicemeta-analysisomega-3
fatty
acidssugar-sweetened
drinks
Язык: Английский