Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 2, 2023
Abstract
Epigenetics
regulates
gene
expression
and
has
been
confirmed
to
play
a
critical
role
in
variety
of
metabolic
diseases,
such
as
diabetes,
obesity,
non-alcoholic
fatty
liver
disease
(NAFLD),
osteoporosis,
gout,
hyperthyroidism,
hypothyroidism
others.
The
term
‘epigenetics’
was
firstly
proposed
1942
with
the
development
technologies,
exploration
epigenetics
made
great
progresses.
There
are
four
main
epigenetic
mechanisms,
including
DNA
methylation,
histone
modification,
chromatin
remodelling,
noncoding
RNA
(ncRNA),
which
exert
different
effects
on
diseases.
Genetic
non-genetic
factors,
ageing,
diet,
exercise,
interact
jointly
affect
formation
phenotype.
Understanding
could
be
applied
diagnosing
treating
diseases
clinic,
biomarkers,
drugs,
editing.
In
this
review,
we
introduce
brief
history
well
milestone
events
since
proposal
‘epigenetics’.
Moreover,
summarise
research
methods
general
mechanisms
modulation.
Furthermore,
interaction
between
genetic
or
factors.
Finally,
clinical
trials
applications
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 14, 2023
Abstract
Cardiac
aging
is
evident
by
a
reduction
in
function
which
subsequently
contributes
to
heart
failure.
The
metabolic
microenvironment
has
been
identified
as
hallmark
of
malignancy,
but
recent
studies
have
shed
light
on
its
role
cardiovascular
diseases
(CVDs).
Various
pathways
cardiomyocytes
and
noncardiomyocytes
determine
cellular
senescence
the
heart.
Metabolic
alteration
common
process
throughout
cardiac
degeneration.
Importantly,
involvement
injuries,
including
failure
myocardial
ischemia
infarction,
reported.
However,
complexity
among
human
hearts
hinders
development
strategies
that
targets
susceptibility.
Advances
over
past
decade
linked
with
their
reprogramming
pathway
aging,
autophagy,
oxidative
stress,
epigenetic
modifications,
chronic
inflammation,
myocyte
systolic
phenotype
regulation.
In
addition,
status
involved
crucial
aspects
biology,
from
fibrosis
hypertrophy
inflammation.
further
elucidation
metabolism
degeneration
still
needed.
Thus,
deciphering
mechanisms
underlying
how
impacts
thought
contribute
novel
interventions
protect
or
even
restore
hearts.
Here,
we
summarize
emerging
concepts
about
landscapes
specific
focuses
why
profile
alters
during
could
utilize
current
knowledge
improve
management
aging.
Circulation Research,
Год журнала:
2025,
Номер
136(5), С. 524 - 550
Опубликована: Фев. 27, 2025
Cardiovascular
diseases
(CVDs)
are
experiencing
a
rapid
surge
and
widely
recognized
as
the
leading
cause
of
mortality
in
current
aging
society.
Given
multifactorial
etiology
CVDs,
understanding
intricate
molecular
cellular
mechanisms
is
imperative.
Over
past
2
decades,
many
scientists
have
focused
on
Sirtuins,
family
nicotinamide
adenine
dinucleotide–dependent
deacylases.
Sirtuins
highly
conserved
across
species,
from
yeasts
to
primates,
play
crucial
role
linking
diseases.
participate
nearly
all
key
physiological
pathological
processes,
ranging
embryogenic
development
stress
response
aging.
Abnormal
expression
activity
exist
aging-related
diseases,
while
their
activation
has
shown
efficacy
mitigating
these
(eg,
CVDs).
In
terms
research,
this
field
maintained
fast,
sustained
growth
recent
years,
fundamental
studies
clinical
trials.
review,
we
present
comprehensive,
up-to-date
discussion
biological
functions
roles
regulating
cardiovascular
biology
CVDs.
Furthermore,
highlight
latest
advancements
utilizing
Sirtuin-activating
compounds
dinucleotide
boosters
potential
pharmacological
targets
for
preventing
treating
The
unresolved
issues
field—from
chemicobiological
regulation
Sirtuin-targeted
CVD
investigations—are
also
discussed.
This
timely
review
could
be
critical
updated
knowledge
Sirtuin
CVDs
facilitating
accessibility
Sirtuin-targeting
interventions.
European Heart Journal,
Год журнала:
2023,
Номер
44(29), С. 2746 - 2759
Опубликована: Май 31, 2023
The
mechanisms
underlying
ageing-induced
vascular
remodelling
remain
unclear.
This
study
investigates
the
role
and
of
cytoplasmic
deacetylase
sirtuin
2
(SIRT2)
in
remodelling.
Cells,
Год журнала:
2024,
Номер
13(17), С. 1469 - 1469
Опубликована: Сен. 1, 2024
NAD+-dependent
deacetylase
sirtuin-1
(Sirt1)
belongs
to
the
sirtuins
family,
known
be
longevity
regulators,
and
exerts
a
key
role
in
prevention
of
vascular
aging.
By
aging,
expression
levels
Sirt1
decline
with
severe
impact
on
function,
such
as
rise
endothelial
dysfunction,
which
turn
promotes
development
cardiovascular
diseases.
In
this
context,
activity
preventing
senescence
is
particularly
important.
Given
counteracting
senescence,
great
efforts
have
been
made
deepen
knowledge
about
intricate
cross-talks
interactions
other
molecules,
order
set
up
possible
strategies
boost
prevent
or
treat
The
aim
review
provide
proper
background
regulation
function
endothelium
discuss
recent
advances
regarding
therapeutic
targeting
counteract
Hypertension,
Год журнала:
2024,
Номер
81(6), С. 1218 - 1232
Опубликована: Март 21, 2024
Inflammatory
responses
in
small
vessels
play
an
important
role
the
development
of
cardiovascular
diseases,
including
hypertension,
stroke,
and
vessel
disease.
This
involves
various
complex
molecular
processes
oxidative
stress,
inflammasome
activation,
immune-mediated
responses,
protein
misfolding,
which
together
contribute
to
microvascular
damage.
In
addition,
epigenetic
factors,
DNA
methylation,
histone
modifications,
microRNAs
influence
vascular
inflammation
injury.
These
phenomena
may
be
acquired
during
aging
process
or
due
environmental
factors.
Activation
proinflammatory
signaling
pathways
events
induce
low-grade
chronic
with
consequent
Identifying
mechanism-specific
targets
might
provide
opportunities
novel
therapeutic
approaches.
Monoclonal
antibodies
targeting
inflammatory
cytokines
drugs,
show
promise
reducing
associated
diseases.
this
article,
we
a
comprehensive
discussion
mechanisms
underlying
offer
insights
into
innovative
strategies
that
ameliorate
injury
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 2, 2025
Exposure
to
traumatic
noise
triggers
cochlear
damage
and
consequently
causes
permanent
sensorineural
hearing
loss.
However,
effective
treatment
strategies
for
noise-induced
loss
(NIHL)
are
lacking.
Sirtuin
1
(SIRT1)
is
a
NAD+-dependent
deacetylase
that
plays
critical
role
in
multiple
physiological
pathological
events.
its
NIHL
pathogenesis
remains
elusive.
This
study
revealed
SIRT1
expression
the
cochlea
progressively
decreases
mouse
model
of
NIHL.
Hair
cell-specific
knockout
exacerbates
outer
inner
hair
cell
synaptic
ribbons,
retraction
nerve
terminals,
oxidative
stress,
leading
more
severe
Conversely,
adeno-associated
virus
(AAV)-mediated
overexpression
effectively
attenuated
most
alleviated
Transcriptomic
analysis
deficiency
impairs
glucose
metabolism
inhibits
antioxidant
pathways
following
exposure
noise.
Further
investigation
exerts
an
effect,
at
least
part,
through
AMPK
activation
cultured
auditory
HEI-OC1
cells
exposed
stress.
Collectively,
these
findings
indicate
essential
maintenance
redox
balance
mitochondrial
function
after
exposure,
thus
providing
promising
therapeutic
target
treatment.
Metabolites,
Год журнала:
2023,
Номер
13(2), С. 244 - 244
Опубликована: Фев. 7, 2023
High
serum
uric
acid
(SUA)
and
triglyceride
(TG)
levels
might
promote
high-cardiovascular
risk
phenotypes
across
the
cardiometabolic
spectrum.
However,
SUA
predictive
power
in
presence
of
normal
high
TG
has
never
been
investigated.
We
included
8124
patients
from
URic
Right
for
heArt
Health
(URRAH)
study
cohort
who
were
followed
over
20
years
had
no
established
cardiovascular
disease
or
uncontrolled
metabolic
disease.
All-cause
mortality
(ACM)
(CVM)
explored
by
Kaplan-Meier
estimator
Cox
multivariable
regression,
adopting
recently
defined
cut-offs
ACM
(≥4.7
mg/dL)
CVM
(≥5.6
mg/dL).
Exploratory
analysis
subgroups
a
sensitivity
using
SUA/serum
creatinine
performed
as
validation.
predicted
(HR
1.25
[1.12-1.40],
