The Dietary Inflammatory Index is Associated with Reduced Kidney Function in Atherosclerotic Cardiovascular Disease Patients DOI Creative Commons

Sanling Shi,

Leilei Du, Yimin Zhou

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 4, 2023

Abstract Background Dietary patterns are strongly correlated with chronic inflammation. Inflammatory processes play a crucial role in maintaining renal homeostasis and function. The dietary inflammatory potential can be assessed through the Index (DII), which has shown positive association higher likelihood of kidney disease (CKD) healthy individuals. However, applicability DII assessing atherosclerotic cardiovascular (ASCVD) patients not been evaluated. Methods This cross-sectional study enrolled 3,599 adult participants ASCVD taken from National Health Nutrition Examination Survey (NHANES) conducted between 1999 2018. Systematic collection baseline data was performed for all participants. Patients were categorized into four groups according to DII. function score using linear regression analysis. Multivariable logistic investigate correlation CKD. Furthermore, restricted cubic spline (RCS) analysis employed explore non-linear correlations Results In models adjusted range possible confounders, demonstrated serum creatinine (p < 0.001) an inverse estimated glomerular filtration rate calculated MDRD equation 0.001). Compared individuals without CKD, those CKD had significantly elevated scores revealed significant high CKD; after classifying quartiles fully adjusting, highest quartile (quartile 4) showed increased risk compared lowest 1) (95% CI: 1.045–1.613, P = 0.019). Using analysis, relationship uncovered developing Conclusion utilized assess adults diagnosed ASCVD. findings that associated decreased independent factor development Our underscore importance diet low reduce this population.

Язык: Английский

Ziltivekimab for anemia and atherosclerosis in chronic kidney disease: a new hope? DOI
Mehmet Kanbay, Mazlum Çöpür, Zeynep Yılmaz Şükranlı

и другие.

Journal of Nephrology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Язык: Английский

Процитировано

0
Terbinafine in acrylic polymer for the treatment of onychomycosis in hemodialysis patients: a phase II clinical trial DOI Creative Commons

Jeanne Marie Queiroz Borges Bersano,

Matheus Gobbo Cordeiro,

Juliana Mozer Sciani

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 26, 2024

Onychomycosis is a nail infection caused by dermatophyte fungi, non-dermatophyte and yeast. Patients with chronic kidney disease on dialysis are part of the population that presents higher rates this disease, mainly due to immunosuppression. Among patients dialysis, treatment onychomycosis complex, limitations imposed comorbidities. In context, study evaluated safety potential efficacy combines debridement use acrylic gel nails carrying terbinafine at concentration 2%.

Язык: Английский

Процитировано

0
Precision Medicine in Erythropoietin Deficiency and Treatment Resistance: A Novel Approach in management of Anemia of Chronic Kidney Disease DOI Open Access
Nava Yugavathy, Bashar Mudhaffar Abdullah, Soo Kun Lim

и другие.

Опубликована: Июнь 28, 2023

Anemia is a well-developed discipline where the concepts of precision medicine have, in part and being studied extensively. This review discusses treatment EPO-deficient anemia resistance Chronic Kidney Disease (CKD). Traditionally, erythropoietin-stimulating agents (ESA) iron supplementation have been used to manage CKD. However, these treatments potential risks, including cardiovascular thromboembolic events. Newer emerged address such as slow-release low-dosage intravenous iron, oral erythropoietin-iron combination therapy. Another novel approach using hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI). highlights need for targeting genetic components CKD individual variability genes erythropoietin gene (EPO), Interleukin-β (IL-β), (HIF). Pharmacogenomics testing aims provide targeted therapies interventions that are tailored specific characteristics an individual, optimizing outcomes minimizing adverse effects. The article concludes by suggesting receptor modification revolutionize outcome deficiency through integration mentioned approach.

Язык: Английский

Процитировано

1
Precision Medicine in Erythropoietin Deficiency and Treatment Resistance: A Novel Approach to Management of Anaemia in Chronic Kidney Disease DOI Creative Commons
Nava Yugavathy, Bashar Mudhaffar Abdullah, Soo Kun Lim

и другие.

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(8), С. 6550 - 6563

Опубликована: Авг. 7, 2023

The study of anaemia is a well-developed discipline where the concepts precision medicine have, in part, been researched extensively. This review discusses treatment erythropoietin (EPO) deficiency and resistance cases chronic kidney disease (CKD). Traditionally, erythropoietin-stimulating agents (ESAs) iron supplementation have used to manage CKD. However, these treatments pose potential risks, including cardiovascular thromboembolic events. Newer emerged address such as slow-release low-dosage intravenous iron, oral supplementation, erythropoietin–iron combination therapy. Another novel approach use hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs). highlights need for targeting genetic components EPO CKD individual variability genes gene (EPO), interleukin-β (IL-β), (HIF). Pharmacogenetic testing aims provide targeted therapies interventions that are tailored specific characteristics an individual, thus optimising outcomes minimising adverse effects. article concludes by suggesting receptor modification has revolutionise patients with through integration mentioned approach.

Язык: Английский

Процитировано

1
The Dietary Inflammatory Index is Associated with Reduced Kidney Function in Atherosclerotic Cardiovascular Disease Patients DOI Creative Commons

Sanling Shi,

Leilei Du, Yimin Zhou

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 4, 2023

Abstract Background Dietary patterns are strongly correlated with chronic inflammation. Inflammatory processes play a crucial role in maintaining renal homeostasis and function. The dietary inflammatory potential can be assessed through the Index (DII), which has shown positive association higher likelihood of kidney disease (CKD) healthy individuals. However, applicability DII assessing atherosclerotic cardiovascular (ASCVD) patients not been evaluated. Methods This cross-sectional study enrolled 3,599 adult participants ASCVD taken from National Health Nutrition Examination Survey (NHANES) conducted between 1999 2018. Systematic collection baseline data was performed for all participants. Patients were categorized into four groups according to DII. function score using linear regression analysis. Multivariable logistic investigate correlation CKD. Furthermore, restricted cubic spline (RCS) analysis employed explore non-linear correlations Results In models adjusted range possible confounders, demonstrated serum creatinine (p < 0.001) an inverse estimated glomerular filtration rate calculated MDRD equation 0.001). Compared individuals without CKD, those CKD had significantly elevated scores revealed significant high CKD; after classifying quartiles fully adjusting, highest quartile (quartile 4) showed increased risk compared lowest 1) (95% CI: 1.045–1.613, P = 0.019). Using analysis, relationship uncovered developing Conclusion utilized assess adults diagnosed ASCVD. findings that associated decreased independent factor development Our underscore importance diet low reduce this population.

Язык: Английский

Процитировано

0