Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 8, 2025
The
association
between
the
recently
updated
cardiovascular
health
(CVH)
assessment
algorithm,
Life's
Essential
8
(LE8),
and
all-cause
mortality
among
adults
with
depression
remains
unknown.
From
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2005–2018,
a
cohort
of
2,935
individuals
diagnosed
was
identified.
Their
CVH
evaluated
through
LE8
score
system.
investigation
status
utilized
connections
Death
Index
up
to
December
31,
2019.
To
assess
impact
on
risk,
Kaplan-Meier
survival
analysis
Cox
proportional
hazards
models,
adjusting
for
variables
related
demographics
socioeconomic
status,
were
applied.
Among
participants,
those
higher
levels
had
significantly
lower
compared
levels.
regression
analyses
demonstrated
that
each
1-point
increase
in
associated
risk
[HR
=
0.97,
95%CI:0.96–0.98].
inverse
persisted
across
different
demographic
subgroups.
Higher
depression.
These
findings
underscore
importance
comprehensive
management
as
part
healthcare
strategies
people
depression,
suggesting
improving
may
contribute
longer
life
expectancy
this
vulnerable
population.
JAMA Network Open,
Год журнала:
2024,
Номер
7(12), С. e2447902 - e2447902
Опубликована: Дек. 6, 2024
Importance
The
American
Heart
Association
proposed
Life’s
Essential
8
(LE8)
as
an
enhanced
measurement
tool
for
cardiovascular
health.
Objective
To
examine
the
association
of
LE8
with
risk
atherosclerotic
disease
(ASCVD)
incidence
and
prognosis
in
veterans.
Design,
Setting,
Participants
This
was
a
prospective
cohort
study
US
veterans
enrolled
Department
Veterans
Affairs
(VA)
Million
Veteran
Program
(MVP)
between
2011
2022.
Data
were
analyzed
from
2023
to
2024.
Exposure
score
ranged
0
100,
higher
indicating
better
Main
Outcomes
Measures
primary
outcome
total
ASCVD
without
baseline
ASCVD,
secondary
major
adverse
event
(MACE)
among
at
baseline.
Results
A
413
052
(mean
[SD]
age,
65.8
[12.1]
years;
378
162
[91.6%]
male)
included.
Based
on
1.7
million
person-years
follow-up
279
868
any
baseline,
45
067
had
during
follow-up.
Total
each
component
factor
associated
incident
inverse,
linear,
dose-response
manner.
For
prior
those
80
100
lower
compared
49
(adjusted
hazard
ratio
[aHR],
0.36
[95%
CI,
0.35-0.38]).
Similarly,
MACE
significantly
regardless
status
(with
ASCVD:
aHR,
0.52
0.48-0.56];
0.14
0.13-0.15])
49.
Conclusions
Relevance
In
this
veterans,
scores
likelihood
developing
events
These
results
support
utility
health
promotion
prevention.
Primary care diabetes,
Год журнала:
2023,
Номер
17(5), С. 420 - 428
Опубликована: Авг. 10, 2023
Vascular
complications
are
the
leading
causes
of
reduced
life
quality
and
mortality
in
type
2
diabetes
mellitus
(T2DM).
Life's
Essential
8
(LE8)
is
a
newly
modified
measurement
cardiovascular
health
(CVH)
by
American
Heart
Association
(AHA).
Promoting
CVH
has
been
previously
shown
to
improve
prognosis
T2DM.
However,
studies
regarding
effects
LE8
on
diabetic
retinopathy
(DR),
major
microvascular
complication,
death
from
overall
T2DM
currently
lacking.
This
study
aimed
investigate
these
associations
thus
providing
preliminary
evidence.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 12, 2024
Background
Life’s
essential’
8
(LE8)
is
a
newly
updated
cardiovascular
health
(CVH)
metrics
from
the
American
Heart
Association,
with
close
relevance
to
metabolism.
Our
objective
explore
association
between
LE8
scores
and
incidence
of
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
advanced
fibrosis
in
adults.
Methods
This
population-based
cross-sectional
study
utilized
data
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2005
2018,
encompassing
adults
aged
20
years
or
older.
Validated
non-invasive
scoring
systems
were
employed
define
steatosis
fibrosis.
Multivariable
logistic
regression
smooth
curve
fitting
techniques
applied
evaluate
associations.
All
analyses
adjusted
for
survey’
complex
design
parameters
accounted
sample
weights.
Results
A
total
11,820
participants
included.
higher
score
was
found
be
inversely
associated
MAFLD
fibrosis,
odds
ratios
(OR)
0.64
(95%
CI:
0.57–0.71)
0.75
0.61–0.92)
per
1
standard
deviation
(SD)
increase
score.
Similar
patterns
relationship
behaviors/factors
In
subgroup
analyses,
interaction
test
showed
that
age,
education
level,
marital
status,
CVD,
hypertension
diabetes
had
significant
impact
on
(all
P
<
0.05).
Among
male,
elderly,
wealthy,
other
race,
depression
participants,
correlation
not
statistically
(
>
Younger
exhibited
more
pronounced
negative
CVH
metric
both
life
Conclusion
its
subscales
presence
non-linear
patterns.
Optimal
may
significantly
reduce
risk
Frontiers in Nutrition,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 6, 2025
Life's
Essential
8
(LE8)
score,
developed
by
the
American
Heart
Association,
assesses
cardiovascular
health
using
eight
components:
diet,
physical
activity,
nicotine
exposure,
sleep
health,
body
mass
index,
lipids,
blood
glucose,
and
pressure.
Liver
function
is
a
critical
indicator
of
overall
with
impairments
linked
to
numerous
chronic
diseases.
While
LE8
score
has
been
extensively
studied
in
relation
outcomes,
its
association
liver
remains
underexplored.
Understanding
this
relationship
crucial
for
integrating
hepatic
management,
particularly
given
shared
metabolic
pathways
underlying
these
systems.
This
study
aims
examine
between
scores
indicators
large
cohort,
addressing
gap
understanding
interplay
health.
Data
from
2007-2018
National
Health
Nutrition
Examination
Survey
(NHANES)
were
used
cross-sectional
study.
The
included
21,873
participants,
stratified
into
low
(0-49),
moderate
(50-79),
high
(80-100)
categories.
markers,
including
alanine
aminotransferase
(ALT),
aspartate
(AST),
alkaline
phosphatase
(ALP),
gamma-glutamyl
transferase
(GGT),
ALT/AST
ratio,
was
evaluated
multivariable
linear
regression,
smoothed
curve
fitting,
threshold
effect
analysis,
weighted
quantile
sum
(WQS)
regression.
Subgroup
analyses
performed
based
on
sex
age
assess
potential
interactions.
Higher
significantly
associated
improved
function,
highlighted
two
major
findings.
First,
nonlinear
associations
observed
parameters,
ALT
stronger
effects
beyond
specific
thresholds
(ALT:
50.625,
ALT/AST:
61.875).
Second,
subgroup
revealed
that
more
pronounced
younger
participants
(<60
years),
suggesting
age-specific
differences
relationship.
These
age-related
might
be
attributed
variations
or
severity
liver-related
risk
factors
older
individuals.
WQS
regression
identified
pressure,
exposure
as
strongest
contributors
markers.
findings
underscore
comprehensive
populations.
suggests
function.
Clinicians
public
practitioners
could
consider
routine
assessments
help
identify
individuals
at
dysfunction,
among
Further
research
should
explore
whether
interventions
targeting
also
improve
outcomes.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 8, 2025
The
association
between
the
recently
updated
cardiovascular
health
(CVH)
assessment
algorithm,
Life's
Essential
8
(LE8),
and
all-cause
mortality
among
adults
with
depression
remains
unknown.
From
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2005–2018,
a
cohort
of
2,935
individuals
diagnosed
was
identified.
Their
CVH
evaluated
through
LE8
score
system.
investigation
status
utilized
connections
Death
Index
up
to
December
31,
2019.
To
assess
impact
on
risk,
Kaplan-Meier
survival
analysis
Cox
proportional
hazards
models,
adjusting
for
variables
related
demographics
socioeconomic
status,
were
applied.
Among
participants,
those
higher
levels
had
significantly
lower
compared
levels.
regression
analyses
demonstrated
that
each
1-point
increase
in
associated
risk
[HR
=
0.97,
95%CI:0.96–0.98].
inverse
persisted
across
different
demographic
subgroups.
Higher
depression.
These
findings
underscore
importance
comprehensive
management
as
part
healthcare
strategies
people
depression,
suggesting
improving
may
contribute
longer
life
expectancy
this
vulnerable
population.
