Metabolic Dysfunction-Associated Steatotic Liver Disease and the Cardiovascular System

Trends in Cardiovascular Medicine, Год журнала: 2025, Номер 35(4), С. 258 - 265

Опубликована: Янв. 21, 2025

Язык: Английский

---

Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 7, 2025

Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular characterized by lipid peroxidation, is involved in pathogenesis diabetic cardiovascular diseases. The susceptibility to ferroptosis hearts possibly related myocardial iron accumulation, abnormal metabolism excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests can be therapeutic target for This review summarizes ferroptosis-related mechanisms novel choices targeting pathways. Further study on ferroptosis-mediated cardiac injury enhance our understanding pathophysiology provide more potential choices.

Язык: Английский

---

Cardiovascular-liver-metabolic health: Time to integrate liver assessment into cardiology practice?

Trends in Cardiovascular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications

Livers, Год журнала: 2025, Номер 5(1), С. 11 - 11

Опубликована: Март 4, 2025

Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic (MASLD), is the most common cause of chronic worldwide. Characterized by excessive hepatic fat accumulation, this encompasses a spectrum from simple steatosis to more severe forms, including steatohepatitis, fibrosis, and cirrhosis. Emerging evidence highlights pivotal role gut dysbiosis in pathogenesis MASLD. Dysbiosis disrupts gut–liver axis, an intricate communication network that regulates metabolic, immune, barrier functions. Alterations microbiota composition, increased permeability, translocation pro-inflammatory metabolites/factors have been shown trigger inflammatory fibrotic cascades, exacerbating inflammation injury. Recent studies identified microbiome signatures associated with MASLD, offering promise non-invasive diagnostic biomarkers paving way for new potential therapeutic strategies targeting dysbiosis. This review explores crucial MASLD need further targeted research field validate microbial optimize strategies. Comprehensive understanding axis may enable innovative approaches, transforming clinical management

Язык: Английский

---

Clinical and Economic Burden of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in a Spanish Mediterranean Region: A Population-Based Study

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2441 - 2441

Опубликована: Апрель 3, 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition worldwide, with significant regional variability in prevalence estimates. This study aimed to determine the prevalence, demographic characteristics, and economic burden of MASLD, metabolic (MASL), steatohepatitis (MASH) Valencian Community region Spain. Methods: We conducted retrospective analysis electronic medical records from public healthcare database individuals aged over 24 years 2012 2019. Results: Of 3,411,069 included 2019, 75,565 were diagnosed 74,065 MASL, 1504 MASH based on International Classification Diseases (ICD), corresponding 2.22%, 2.17%, 0.04%, respectively. Among type 2 diabetes mellitus (T2DM) or obesity, MASLD was approximately three times 2.5 higher, respectively, compared overall population. The increased 2019 all populations studied. highest risk hospitalization associated liver-related causes, followed by all-cause hospitalization. cost per subject observed concomitant T2DM. Conclusions: Our findings indicate rising MASH, despite their potential underdiagnosis during period. presence high costs, particularly patients results underline need for more effective strategies enhance awareness improve resource allocation.

Язык: Английский

---

Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos

Circulation Research, Год журнала: 2025, Номер 136(11), С. 1170 - 1207

Опубликована: Май 22, 2025

Over the past few decades, rising burden of metabolic disease, including type 2 diabetes, prediabetes, obesity, and dysfunction–associated steatotic liver has corresponded with fundamental shifts in landscape heart failure (HF) epidemiology, prevalence HF preserved ejection fraction. It become increasingly important to understand role extracardiac contributors interorgan communication pathophysiology phenotypic heterogeneity HF. Whereas traditional epidemiological strategies have separately examined individual contributions specific comorbidities risk, these approaches may not capture shared mechanisms more complex, bidirectional relationships between cardiac noncardiac comorbidities. In this review, we highlight cardiac, kidney, liver, metabolism multiorgan interactions pathways that complicate development progression propose research further context multiple organ disease. This includes evolving such as multiomics machine learning which better common underlying crosstalk. We review existing preclinical models how they enhanced our understanding disease subtypes. suggest recommendations clinical practice across specialties should screen for manage involvement Finally, recognizing advent novel combinatorial therapeutic agents indications cardiac-kidney-liver continuum, current trials landscape. specifically a pressing need design inclusive examine multimorbidity incorporate end points, lead outcomes are evermore clinically relevant today.

Язык: Английский

---

Muscle Strength and Cardiovascular Health in MASLD: A Prospective Study

Medicina, Год журнала: 2025, Номер 61(2), С. 247 - 247

Опубликована: Фев. 1, 2025

Background and Objectives: The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains incompletely understood. However, recent studies highlight the interactions between muscle, liver, adipose tissue. This study aimed to explore relationships clinical indicators MASLD sarcopenia, cardiorespiratory fitness, fatigue, mood. Materials Methods: involved 60 participants, including 28 healthy controls 32 with MASLD, categorized into two subgroups: 15 MASL 17 steatohepatitis (MASH). Participants completed an incremental speed shuttle walk test evaluate a hand-held dynamometer assessment for appendicular muscle strength, timed up go physical performance. Physical activity level, quality life, emotional state were assessed using questionnaires. results compared groups characteristics. Results: MASH showed reduced fitness (p < 0.001). knee extensors significantly weaker in both 0.001 p = 0.001, respectively). group reported higher levels depression negative health perception 0.006 0.03, Muscle strength patients significant association (OR −0.384, 95% CI: −3.10 −0.74, 0.003), intrahepatic triglyceride content −0.287, −1.31 −0.11, 0.023), LDL −0.286, −0.02 −0.33, 0.03). In contrast, positive was observed VO2 0.531, CI 1.27 3.47, Conclusions: suggests that is linked key parameters, such as hepatic fat, levels, aerobic capacity, may contribute development progression MASLD. Interventions at preserving or enhancing be essential preventing damage improving health.

Язык: Английский

---

From Liking to Following: The Role of Food Preferences, Taste Perception, and Lifestyle Factors in Adherence to the Mediterranean Diet Among Young Individuals

Nutrients, Год журнала: 2025, Номер 17(3), С. 600 - 600

Опубликована: Фев. 6, 2025

Background and aims: The Mediterranean diet (MedDiet) is a healthy dietary pattern associated with reduced risk of chronic diseases. However, adherence declining, particularly among younger populations. Therefore, it crucial to identify the main aspects that affect its adherence, food preferences sensory function, which have received insufficient attention. Our aims were investigate impact socio-demographic lifestyle factors on MedDiet young individuals; assess association taste liking adherence; evaluate associations between perception modalities, preferences, adherence. Methods: A cross-sectional study adults (aged 20.5 ± 4.7 years) in country (n = 879) was carried out. Demographic characteristics, clinical anthropometric assessed. Taste for bitter, salty, sweet, sour, umami determined by rating different concentrations prototypical tastants. We computed total score three scores combine preferences. Results: identified several MedDiet, as well determinants. Food significantly MedDiet. Higher preference olive oil, oranges, broccoli, fish, legumes higher (p < 0.05 all). Conversely, sweet foods, red meat, butter lower combined positive strongly 1.4 × 10−23) multivariate adjusted model. negative inversely 1.9 10−8). Likewise, (strong inverse direct bitter preference; both p 0.001). Moreover, foods 0.05). In conclusion, future precision nutrition studies should measure are determinants especially people.

Язык: Английский

---

Helicobacter pylori infection in the pathophysiology of metabolic dysfunction-associated steatotic liver disease and its complications

Опубликована: Март 20, 2025

Язык: Английский

---

Impact of Metabolic Dysfunction-Associated Steatotic Liver Disease on Cardiovascular Structure, Function, and the Risk of Heart Failure

Canadian Journal of Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

---