Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

AJP Heart and Circulatory Physiology, Год журнала: 2023, Номер 325(1), С. H1 - H29

Опубликована: Март 31, 2023

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age identify individuals at elevated CV risk. We review possibilities, limitations, complementarity, differences reduced-order, biophysical models arterial PW propagation, well theoretical empirical methods for analyzing extracting clinically relevant assessment. provide detailed mathematical derivations these methods, showing how they are related each other. Finally, we outline directions future research realize potential modeling analysis accurate assessment in both clinic daily life.

Язык: Английский

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A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium

Life Medicine, Год журнала: 2023, Номер 2(4)

Опубликована: Авг. 30, 2023

Aging of the vasculature, which is integral to functioning literally all human organs, serves as a fundamental physiological basis for age-related alterations well shared etiological mechanism various chronic diseases prevalent in elderly population. China, home world's largest aging population, faces an escalating challenge addressing prevention and management these conditions. To meet this challenge, Biomarker Consortium China has developed expert consensus on biomarkers vascular (VA) by synthesizing literature insights from scientists clinicians. This provides comprehensive assessment associated with VA presents systemic framework classify them into three dimensions: functional, structural, humoral. Within each dimension, panel recommends most clinically relevant biomarkers. For functional domain, reflecting stiffness endothelial function are highlighted. The structural dimension encompasses metrics structure, microvascular distribution. Additionally, proinflammatory factors emphasized humoral dimension. aim establish foundation assessing extent conducting research related VA, ultimate goal improving health globally.

Язык: Английский

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Cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures: the Framingham Heart Study

European Journal of Preventive Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

To assess the cross-sectional and longitudinal associations of smoking behaviour with central arterial haemodynamic measures in samples Framingham Heart Study. In 6597 participants [3606 (55%) women, 51.5% never smoked, 34.8% formerly quit, 4.3% recently 9.3% currently smoking], we assessed relations using multivariable linear regression models. models, were different across groups. Particularly, augmentation index (AI) was higher among who quit (least squares mean ± standard error = 14.1 0.4%; P < 0.001) (18.1 0.5%; compared smoked (12.6 0.3%). Among smoking, cigarettes per day [B 1.41; 95% confidence interval (CI), 0.47-2.34] associated AI. had pack-years AI (B 0.85; CI, 0.60-1.14) pulse pressure 0.84; 0.46-1.21). Using restricted cubic splines, observed a negative association for AI, but non-linear characteristic impedance pressure, time since (all 0.001). Additionally, patterns cessation by burden (<20 vs. ≥20 pack-years). increases persistently (4.62 0.41%; (5.48 0.70%; 0.002) (3.45 0.37%). Central are sensitive to differences changes behaviour. Longer may revert levels lower exposure.

Язык: Английский

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Developing technologies to assess vascular ageing: a roadmap from VascAgeNet

Physiological Measurement, Год журнала: 2024, Номер 45(12), С. 121001 - 121001

Опубликована: Июнь 5, 2024

Abstract Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, can be accelerated disease. Measurements vascular are emerging as markers cardiovascular risk, potential applications in disease diagnosis prognosis, for guiding treatments. However, not yet routinely assessed clinical practice. A key step towards this development technologies to assess ageing. In Roadmap, experts discuss several aspects process, including: measurement technologies; pipeline; applications; future research directions. The Roadmap summarises state art, outlines major challenges overcome, identifies directions address these challenges.

Язык: Английский

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Exploring the Intersection of Geophysics and Diagnostic Imaging in the Health Sciences

Diagnostics, Год журнала: 2024, Номер 14(2), С. 139 - 139

Опубликована: Янв. 8, 2024

To develop diagnostic imaging approaches, this paper emphasizes the transformational potential of merging geophysics with health sciences. Diagnostic technology improvements have transformed sciences by enabling earlier and more precise disease identification, individualized therapy, improved patient care. This review article examines connection between in field Geophysics, which is typically used to explore Earth’s subsurface, has provided new uses its methodology medical field, providing innovative solutions pressing problems. The different geophysical techniques like electrical imaging, seismic their corresponding tomography, magnetic resonance ultrasound etc. examination includes description, similarities, differences, challenges associated these how modified can be methods Examining progression each method from contributions illness diagnosis, treatment planning, monitoring are highlighted. Also, utilization data analysis signal processing inversion image been briefly explained, along mathematical computational tools they implemented for key findings include development machine learning artificial intelligence geophysics-driven demonstrating revolutionary effects data-driven on precision, speed, predictive modeling.

Язык: Английский

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Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms

JVS Vascular Science, Год журнала: 2024, Номер 5, С. 100209 - 100209

Опубликована: Янв. 1, 2024

Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be postsurgical events and has been suggested to a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair aneurysms decreases stiffness, implantation rigid endograft increased following endovascular aneurysm (EVAR). This review aims provide an overview wall physiology contemporary understanding its implications for patients undergoing abdominal repair. Recent data suggests that central arterial estimated preoperatively using pulse wave velocity (PWV), predict sac behavior EVAR, elevated preoperative PWV less shrinkage, even enlargement, after EVAR. With development several simple noninvasive methods measure PWV, such as brachial-ankle single cuff brachial oscillometry, there role monitoring ambulatory outcomes Additionally, since outcomes, EVAR increases assessment prior interventions help guide therapeutic decisions well surveillance protocols, leading optimized outcomes.

Язык: Английский

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Impact of valve-sparing aortic root replacement on aortic fluid dynamics and biomechanics in patients with syndromic heritable thoracic aortic disease

Journal of Cardiovascular Magnetic Resonance, Год журнала: 2024, Номер 26(2), С. 101088 - 101088

Опубликована: Янв. 1, 2024

Patients with syndromic heritable thoracic aortic diseases (sHTAD) who underwent prophylactic root replacement are at high risk of distal events, but the underlying mechanisms remain unclear. This prospective, longitudinal study evaluates impact valve-sparing (VSARR) on fluid dynamics and biomechanics in these patients.

Язык: Английский

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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable

Artery Research, Год журнала: 2024, Номер 30(1)

Опубликована: Сен. 30, 2024

Abstract Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. This paper summarizes insights a roundtable discussion at the Artery 23 conference, featuring perspectives basic science, clinical trials, regulation, industry. The main conclusions of are as follows: science must align with relevance, using appropriate animal models standardized measurement techniques. Pragmatic registry-based trials offer viable alternatives traditional randomized controlled facilitating real-world applicability. regulatory landscape, particularly for software medical devices, evolve keep pace technological advancements like artificial intelligence. Industry efforts focus on developing devices or solutions assessment treatment strategies, yet face hurdles in large-scale adoption reimbursement. Despite progress, development pharmacological interventions mitigate remains critical need. underscores importance interdisciplinary collaboration overcome barriers translate scientific discoveries into practice effectively.

Язык: Английский

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Alterations in aortic elasticity indices among type 2 diabetes patients in a low and middle income country using M-mode echocardiography: A cross-sectional comparative study

PLoS ONE, Год журнала: 2024, Номер 19(10), С. e0305799 - e0305799

Опубликована: Окт. 24, 2024

Diabetes is one of the leading causes noncommunicable diseases worldwide. It known to induce cardiovascular remodeling, which can result in a variety complications, including considerable increase aortic stiffness. While studies Western populations have explored these effects, data on Asians, mainly Vietnamese, are limited. This study aimed assess elasticity type 2 diabetes mellitus (T2DM) patients compared healthy individuals.

Язык: Английский

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Cross-sectional and longitudinal associations of smoking behavior with central arterial hemodynamic measures: The Framingham Heart Study

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Abstract Background Cigarette smoking is a leading modifiable cardiovascular disease risk factor. Cross-sectional studies demonstrated variable relations of behavior with measures vascular function. Additionally, the impact persistent versus changes in behaviors on alterations central arterial function unclear. Methods and Results We assessed associations intensity hemodynamics 6597 participants (51.5% never smoked, 34.8% formerly quit, 4.3% recent 9.3% currently smoking) Framingham Heart Study (N=3606 [55%] women). In cross-sectional models, were different across categories behavior. For example, augmentation index was higher among who quit (least squares mean±standard error=14.1±0.4%; P <0.001) (18.1±0.5%; compared to smoked (12.6±0.3%). Among smoking, cigarettes per day (estimated B =1.41; 95% CI, 0.47—2.34; =0.003) associated index. had pack-years (est. =0.85; 0.60—1.14) pulse pressure =0.84; 0.46—1.21). Using restricted cubic splines, we observed negative linear association for index, but distinct nonlinear characteristic impedance pressure, time since (all <0.001). longitudinal increases persistently (4.62±0.41%; (5.48±0.70%; =0.002) (3.45±0.37%). Conclusion Central are sensitive status Longer cessation may partially revert levels comparable those lower exposure.

Язык: Английский

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