Endothelial dysfunction in adults with congenital heart disease: A systematic review and meta‐analysis DOI Open Access
Amalia Baroutidou, Theodoros Dimitroulas, Alexandra Arvanitaki

и другие.

European Journal of Clinical Investigation, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Abstract Background Adults with congenital heart disease (ACHD) can face a lifelong risk of premature cardiovascular events. Endothelial dysfunction and arterial stiffness may be some the key mechanisms involved. Early identification endothelial damage in ACHD could crucial to mitigate adverse This systematic review meta‐analysis aims investigate micro‐ macroangiopathy ACHD. Methods We systematically searched four major electronic databases (PubMed, CENTRAL, Scopus Web Science), ClinicalTrials.gov grey literature according PRISMA guidelines. included studies evaluating function any semi‐ or non‐invasive method healthy controls. Studies exploring indices carotid intima‐media thickness were also investigated. Results In total, 31 (1118 ACHD, 794 controls) this review. Brachial artery endothelium‐dependent (assessed via flow‐mediated dilatation, FMD) ‐independent vasodilation nitroglycerine‐mediated NMD) attenuated versus controls (mean difference [MD] −2.5, 95% confidence intervals [CI] −3.7; −1.3 MD −3.9, CI −6.8; −1.0, respectively). demonstrated impaired microvascular function, evaluated peripheral tonometry (PAT), significantly lower reactive hyperemia index PAT ratio compared (MD −.26, −.48; −.04 −.4, −.5; Regarding stiffness, pooled analysis revealed non‐significant differences pulse wave velocity between study groups (standardized .2, −.2; .6). However, augmentation was higher 1.6, .8; 2.4). Conclusions exhibit macro‐ elevated factors that responsible for increased events population.

Язык: Английский

Early Diagnosis of Cardiovascular Diseases in the Era of Artificial Intelligence: An In-Depth Review DOI Open Access
Naiela E Almansouri,

Mishael Awe,

Selvambigay Rajavelu

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Март 9, 2024

Cardiovascular diseases (CVDs) are significant health issues that result in high death rates globally. Early detection of cardiovascular events may lower the occurrence acute myocardial infarction and reduce people with CVDs. Traditional data analysis is inadequate for managing multidimensional related to risk prediction CVDs, heart attacks, medical image interpretations, therapeutic decision-making, disease prognosis due complex pathological mechanisms multiple factors involved. Artificial intelligence (AI) a technology utilizes advanced computer algorithms extract information from large databases, it has been integrated into industry. AI methods have shown ability speed up advancement diagnosing treating CVDs such as failure, atrial fibrillation, valvular disease, hypertrophic cardiomyopathy, congenital more. In clinical settings, usefulness illness, improving efficiency supporting tools, stratifying categorizing diseases, predicting outcomes. Advanced intricately designed analyze intricate relationships within extensive healthcare data, enabling them tackle more jobs compared conventional approaches.

Язык: Английский

Процитировано

8
Catheter Ablation in Atrial Fibrillation: Recent Advances DOI Open Access
Sahib Singh, Lohit Garg,

Mohammed Kanjwal

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(24), С. 7700 - 7700

Опубликована: Дек. 17, 2024

Atrial fibrillation (AF) is the leading cause of arrhythmia-related morbidity and mortality. Recurrent symptoms, hospitalizations, cost burden to patients have necessitated treatments beyond antiarrhythmic drugs (AADs) for with AF. Catheter ablation has proven be effective over medical therapy alone; however recurrence rates atrial tachyarrhythmias post-ablation remain significant, particularly in persistent long-standing Hence, new techniques catheter arisen, such as non-thermal energy sources, novel catheters, electroanatomical mapping, additional targets. In this review, we discuss recent advances field ablation, including newer modalities prevention adverse events future perspectives.

Язык: Английский

Процитировано

2
Atrial Fibrillation in Heart Failure Due to Congenial Heart Disease DOI
Robert N. Kerley,

C. Lam,

Anne-Marie Valente-Feliciano

и другие.

Cardiac Electrophysiology Clinics, Год журнала: 2024, Номер 17(1), С. 109 - 124

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

0
Atrial Tachycardia in Patients with Repaired Tetralogy of Fallot; Its Characteristics and Catheter Ablation Outcome DOI Creative Commons

Qasim J. Naeemah,

Miyako Igarashi, Noor K. Albakaa

и другие.

International Journal of Cardiology Congenital Heart Disease, Год журнала: 2024, Номер 19, С. 100558 - 100558

Опубликована: Дек. 10, 2024

Patients with repaired tetralogy of Fallot (TOF) now live longer. However, dysrhythmia becomes prevalent in adults TOF, especially atrial tachyarrhythmia. To identify the characteristics patients who develop tachycardia (AT) and mechanism clinical AT induced one. Seventy-seven TOF were enrolled. The divided into two groups (AT non-AT). Clinical electrophysiologic data studied. mean age was 34 years. Twenty-three had (30 %). In group, left ventricular ejection fraction lower (58 ± 6 vs 62 5; P = 0.011), right area (cm2) larger (29 13 15 < 0.001, 19 3 16 4; respectively), S' wave (cm/s) smaller (8 2 10 3; 0.029).Patients underwent catheter ablation, 32 ablated. intra-atrial reentrant 14 (44 %), cavotricuspid isthmus-dependent 12 (37 focal activity remaining (19 An important finding that after first ablated, another 7 patients. about half them, contrast to ablated AT, where least common. After a median follow-up 37 months, four recurrence. biventricular dysfunction bi-atrial dilatation. Aggressive induction ablation may reduce future

Язык: Английский

Процитировано

0
Endothelial dysfunction in adults with congenital heart disease: A systematic review and meta‐analysis DOI Open Access
Amalia Baroutidou, Theodoros Dimitroulas, Alexandra Arvanitaki

и другие.

European Journal of Clinical Investigation, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Abstract Background Adults with congenital heart disease (ACHD) can face a lifelong risk of premature cardiovascular events. Endothelial dysfunction and arterial stiffness may be some the key mechanisms involved. Early identification endothelial damage in ACHD could crucial to mitigate adverse This systematic review meta‐analysis aims investigate micro‐ macroangiopathy ACHD. Methods We systematically searched four major electronic databases (PubMed, CENTRAL, Scopus Web Science), ClinicalTrials.gov grey literature according PRISMA guidelines. included studies evaluating function any semi‐ or non‐invasive method healthy controls. Studies exploring indices carotid intima‐media thickness were also investigated. Results In total, 31 (1118 ACHD, 794 controls) this review. Brachial artery endothelium‐dependent (assessed via flow‐mediated dilatation, FMD) ‐independent vasodilation nitroglycerine‐mediated NMD) attenuated versus controls (mean difference [MD] −2.5, 95% confidence intervals [CI] −3.7; −1.3 MD −3.9, CI −6.8; −1.0, respectively). demonstrated impaired microvascular function, evaluated peripheral tonometry (PAT), significantly lower reactive hyperemia index PAT ratio compared (MD −.26, −.48; −.04 −.4, −.5; Regarding stiffness, pooled analysis revealed non‐significant differences pulse wave velocity between study groups (standardized .2, −.2; .6). However, augmentation was higher 1.6, .8; 2.4). Conclusions exhibit macro‐ elevated factors that responsible for increased events population.

Язык: Английский

Процитировано

0