Metabolic Syndrome and Efficacy of Remote Ischemic Postconditioning in Acute Moderate Ischemic Stroke: A Post Hoc Analysis of the RICAMIS Trial
Journal of the American Heart Association,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Background
Metabolic
syndrome
(METS)
is
associated
with
poor
outcomes
after
acute
ischemic
stroke.
This
study
aimed
to
investigate
the
relationship
between
METS
and
efficacy
of
remote
postconditioning
(RIPostC)
in
moderate
stroke
using
database
RICAMIS
(Remote
Ischemic
Conditioning
for
Acute
Moderate
Stroke)
trial.
Methods
Results
In
trial,
eligible
participants
were
patients
within
48
hours
onset
who
did
not
receive
reperfusion
treatment.
A
total
1482
enrolled
this
secondary
analysis,
including
(602)
non‐METS
(880)
group
according
definitions
Chinese
Diabetes
Society,
which
was
further
subdivided
into
RIPostC
control
subgroups.
The
primary
outcome
excellent
functional
outcome,
defined
as
a
modified
Rankin
Scale
score
0
1
at
90
days.
differences
clinical
subgroup
compared
or
non‐METS,
respectively,
interaction
effects
treatment
assignment
status
evaluated.
baseline
characteristics
subgroups
across
well
balanced,
except
difference
Trial
Org
10
172
Stroke
Treatment
mechanism
group.
Compared
control,
high
probability
(68.8%
versus
56.1%;
odds
ratio
[OR],
1.751
[95%
CI,
1.248–2.456];
P
=0.001),
but
without
(66.6%
64.6%;
OR,
1.103
0.833–1.461];
=0.494).
Notably,
significant
effect
treatments
(RIPostC
control)
by
different
on
observed
(
=0.039).
Conclusions
analysis
suggests
first
time
that
may
provide
greater
benefit
non‐METS.
Язык: Английский
Remote Ischemic Conditioning to Reduce Perihematoma Edema in Patients with Intracerebral Hemorrhage (RICOCHET): A Randomized Control Trial
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(9), С. 2696 - 2696
Опубликована: Май 3, 2024
Background:
Early
perihematomal
edema
(PHE)
growth
is
associated
with
worse
functional
outcomes
at
90
days.
Remote
Ischemic
conditioning
(RIC)
may
reduce
inflammation
if
applied
early
to
patients
intracerebral
hemorrhage
(ICH).
We
hypothesize
that
RIC,
delivered
for
seven
days
in
spontaneous
ICH,
PHE
growth.
Methods:
ICH
presenting
within
6
h
of
symptom
onset
and
hematoma
volume
<
60
milliliters
(mL)
were
randomized
an
RIC
+
standard
care
or
(SC)
group.
The
primary
outcome
measure
was
calculated
extension
distance
(EED),
the
cm
assessed
on
day
seven.
Results:
Sixty
a
mean
±
SD
age
57.5
10.8
years,
twenty-two
(36.7%)
female.
relative
baseline
median
similar
(RIC
group
0.75
(0.5–0.9)
mL
vs.
SC
0.91
(0.5–1.2)
mL,
p
=
0.30).
EEDs
0.58
(0.3–0.8)
0.51
cm,
0.76).
There
no
difference
7
EED
1.1
(0.6–1.2)
1
(0.9–1.2)
0.75).
Conclusions:
therapy
daily
feasible.
However,
decrease
noted
intervention.
Язык: Английский