Effect of PM2.5 and its constituents on hospital admissions for cardiometabolic multimorbidity in Urumqi, China

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 21, 2025

Cardiometabolic multimorbidity (CMM) is caused by two or more of the diseases ischemic heart disease (CVD), type 2 diabetes mellitus (T2DM), and stroke, therefore requires hospitalization healthcare costs. However, few studies have investigated fine particulate matter (PM2.5) its constituents risk hospital admissions for CMM. We aimed to study these associations in Urumqi, a representative area northwest China. The effect PM2.5 on CMM was determined using quantile-based g-computation (QBGC) bayesian kernel machine regression (BKMR) method, which with greatest were ranked as NO3− > SO42− NH4+ BC OM. Among all constituents, presented highest risk, largest observed at lag 21-day maximum concentration (RR = 2.079, 95% CI: 1.396–3.097). Per IQR increase had significantly IHD 1.079, 1.028–1.132) 1.094, 1.039–1.152). Female patients hospitalized indicated heightened sensitivity elevated levels 1.170, 1.077–1.271). interaction between high concentrations low temperature, relative humidity (RH), sunshine duration (SSD) affected Additionally, cold waves, defined minimum temperature below P2.5 sustained 5 days (CW5), intensified constituents.

Язык: Английский

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Hypothetical Behavioral Interventions for Mitigating the Cardiovascular Effects of Long‐Term Fine Particulate Matter Exposure: Analyses From 2 Prospective Cohorts

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Background Whether healthy behaviors can attenuate the adverse association between ambient fine particulate matter (PM 2.5 ) and cardiovascular disease (CVD) is inconclusive. METHODS AND RESULTS The parametric g‐formula was used to quantify potential reduction in PM effect on CVD under different scenarios of hypothetical behavioral interventions (including dietary patterns, physical activity, body mass index, alcohol consumption, smoking, supplements). Feasible intervention scenarios, defined basis values considered feasible previous real‐world (eg, overweight participants lose 6.69% their weight). Intensive which all are adopting completely maintain normal We also estimate joint that incorporate above behaviors. Long‐term exposure associated with incident both cohorts, risk difference per 1000 person‐years for a 5 μg/m 3 increase being 1.42 (95% CI, 1.04–1.79) UKB (UK Biobank) 2.15 1.65–2.59) Sichuan Cohort (China Multi‐Ethnic Cohort, Region). In intensive improving diet, index could significantly reduce CVD, reduced proportion ranging from 4.59% 37.22%. A 6 would by 31.47% (10.13%–57.26%) 19.75% (10.78%–42.89%) low‐pollution UK Biobank high‐pollution cohort, respectively. combination more 57.51% (21.64%–100.69%) 45.54% (22.66%–106.66%), Conclusions Healthier serve as individual‐level complementary strategies emission control minimizing health impact , whether high‐ or areas.

Язык: Английский

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Mediation Role of Gut Microbiota in the Association Between Ambient Fine Particulate Matter Components and Cardiovascular Disease: Evidence from a China Cohort

Environmental Research, Год журнала: 2025, Номер unknown, С. 121421 - 121421

Опубликована: Март 1, 2025

Язык: Английский

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Chemical Concentrations, Source Emission, Potential Toxicity, and Health Risk of Ambient Fine Particulate Matter and Its Constituents: A Recent Literature Review

Current Pollution Reports, Год журнала: 2024, Номер 11(1)

Опубликована: Окт. 9, 2024

Язык: Английский

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Differential effects of fine particulate matter constituents on acute coronary syndrome onset

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 30, 2024

Fine particulate matter has been linked with acute coronary syndrome. Nevertheless, the key constituents remain unclear. Here, we conduct a nationwide case-crossover study in China during 2015-2021 to quantify associations between fine (organic matter, black carbon, nitrate, sulfate, and ammonium) syndrome, identify critical contributors. Our findings reveal all five are significantly associated syndrome onset. The magnitude of peaks on concurrent day, attenuates thereafter, becomes null at lag 2 day. largest effects observed for organic each interquartile range increase their concentrations corresponding 2.15% 2.03% increases onset, respectively. These two components also contribute most joint effects, accounting 31% 22%, highlight tailored clinical management targeted control carbonaceous protect cardiovascular health.

Язык: Английский

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Characterization and regional linkage analysis of PM2.5 emissions driven by energy consumption in mainland China, 2007–2017

Journal of Environmental Management, Год журнала: 2024, Номер 373, С. 123615 - 123615

Опубликована: Дек. 10, 2024

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