White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis DOI Creative Commons
Qiaohui Ying, M Y Wang, Zichen Zhao

и другие.

Nature and Science of Sleep, Год журнала: 2024, Номер Volume 16, С. 2045 - 2061

Опубликована: Дек. 1, 2024

Sleep apnea (SA), associated with absent neural output, is characterised by recurrent episodes of hypoxemia and repeated arousals during sleep, resulting in decreased sleep quality various health complications. Mitochondrial DNA copy number (mtDNA-CN), an easily accessible biomarker blood, reflects mitochondrial function. However, the causal relationship between mtDNA-CN SA remains unclear. This study aimed to investigate causality while identifying potential mediating brain imaging phenotypes (BIPs).

Язык: Английский

Evaluation of the Prevalence of Sleep Disorders and Their Association with Stroke: A Hospital-Based Retrospective Study DOI Open Access

Majed Alabdali,

Abdulrahim Saleh Alrasheed,

Faynan Sultan Alsamih

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1313 - 1313

Опубликована: Фев. 16, 2025

Background: Sleep disturbances are prevalent among stroke survivors, significantly impacting their recovery and quality of life. This study aimed to evaluate the prevalence sleep disorders, quality, risk obstructive apnea (OSA), daytime sleepiness survivors identify potential associations with clinical demographic factors. Materials Methods: A retrospective observational analyzed adult (aged ≥ 18 years) attending neurology clinics at our institution from November 2022 2024. The primary outcome measures included overall assessment. Data were collected using validated Arabic versions Pittsburgh Quality Index (PSQI), STOP-Bang Questionnaire, Epworth Sleepiness Scale (ESS). Statistical analyses, including Chi-square tests t-tests, performed SPSS version 30.1. Results: total 100 mostly aged 40-60 years, recruited in study. disorders was 60.0%, poor reflected by a mean global PSQI score 9.13 ± 14.40. Additionally, 19.0% high OSA, 24.0% experienced abnormal sleepiness. While no statistically significant found between or factors, trends indicated higher disorder those hemorrhagic high-risk OSA profiles. Conclusions: Our highlights emphasizing need for regular assessments. Future studies should explore objective assessments larger sample sizes validate these findings assess implication

Язык: Английский

Процитировано

0

Screening Sleep-Disordered Breathing (SDB) in the Everyday Dental Office – Pediatric and Adult Patients DOI
Heesoo Oh,

M Arab,

Eo‐Jin Kim

и другие.

Seminars in Orthodontics, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Sleep-Disordered Breathing and Hypertension—A Systematic Review DOI Open Access
Ayman Battisha,

Amrit Kahlon,

D. Kalra

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(9), С. 3115 - 3115

Опубликована: Апрель 30, 2025

Background/Objectives: Sleep-disordered breathing (SDB), historically referred to as "sleep apnea syndrome", particularly obstructive sleep (OSA), is an independent risk factor for hypertension (HTN), stroke, heart failure, arrhythmias, and other cardiovascular disorders. Despite the well-established link between OSA HTN its high occurrence in disorders, focus on complex OSA-HTN axis often overlooked or inadequately managed, which might explain lack of notable improvements outcomes this patient population. Understanding relationship crucial due significant implications clinical practice public health. Methods: Using expanded list relevant MeSH terms, including "sleep-disordered breathing" following PRISMA model, peer-reviewed articles were systematically selected. Studies published from January 2000 through December 2024 identified screened based predefined inclusion exclusion criteria. Results: This review emphasizes both OSA's interaction effects health across different populations. It identifies key factors mediating association HTN. Conclusions: Multimodal management, continuous positive airway pressure lifestyle modification, essential treating related OSA. Effective management vital improving outcomes.

Язык: Английский

Процитировано

0

SLEEP APNEA IS A COMMON AND DANGEROUS CARDIOVASCULAR RISK FACTOR DOI
Robert J. Henning,

W. McDowell Anderson

Current Problems in Cardiology, Год журнала: 2024, Номер unknown, С. 102838 - 102838

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

3

Association of Body Roundness Index and A Body Shape Index with Obstructive Sleep Apnea: insights from NHANES 2015–2018 data DOI Creative Commons
Xue Pan, Fang Liu, Jiayi Fan

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Ноя. 18, 2024

Objective This study examines the relationship between several anthropometric indices-Body Roundness Index (BRI), A Body Shape (ABSI), Waist-to-Weight (WWI), Waist Circumference (WC), and Mass (BMI)-and prevalence of Obstructive Sleep Apnea (OSA) using data from National Health Nutrition Examination Survey (NHANES) spanning 2015 to 2018. Methods retrospective cross-sectional analysis 7,004 adult participants was conducted NHANES 2015–2018 data. Multivariable-adjusted logistic regression models were employed assess association BRI, ABSI, OSA. Non-linear relationships explored via smooth curve fitting threshold effect a two-part linear model. Subgroup analyses identified sensitive populations, discriminatory power indices in screening OSA assessed Receiver Operating Characteristic (ROC) curves. Results The revealed significant positive BRI OSA, with observed at 4.3. Below this threshold, risk increased higher BRI; however, no found above threshold. Similarly, ABSI demonstrated 8.2, positively associated left negatively right. indicated stronger associations younger non-diabetic populations. ROC as promising predictive tool for an AUC 0.64 (95% CI: 0.62–0.65). Conclusion demonstrates potential index incidence, warranting further large-scale prospective studies validate these findings.

Язык: Английский

Процитировано

3

Sleep Disordered Breathing and Neurocognitive Disorders DOI Open Access
Ikechukwu Ogbu,

Tushar Menon,

Vipanpreet Chahil

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(17), С. 5001 - 5001

Опубликована: Авг. 23, 2024

Sleep-disordered breathing (SDB), which includes conditions such as obstructive sleep apnea (OSA) and central (CSA), is an independent risk factor for cerebral small vessel disease (CSVD), stroke, heart failure, arrhythmias, other cardiovascular disorders. The influence of OSA on brain structure cognitive function has become essential focus in the heart-brain axis, given its potential role developing neurocognitive abnormalities. In this review, we found that plays a significant cardio-neural pathway leads to development decline. Although data still limited topic, understanding critical axis could lead utilization imaging modalities simultaneously identify early signs pathology both organ systems based known OSA-driven pathological pathways result state cerebrovascular systems. This narrative review aims summarize current link between disorders, pathophysiology, treatment options available patients with OSA-related

Язык: Английский

Процитировано

1

Letter to Editor concerning “The association between cardiovascular health and depression: Results from the 2007–2020 NHANES” DOI
Bhaskar Thakur

Psychiatry Research, Год журнала: 2024, Номер 342, С. 116172 - 116172

Опубликована: Сен. 8, 2024

Язык: Английский

Процитировано

0

White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis DOI Creative Commons
Qiaohui Ying, M Y Wang, Zichen Zhao

и другие.

Nature and Science of Sleep, Год журнала: 2024, Номер Volume 16, С. 2045 - 2061

Опубликована: Дек. 1, 2024

Sleep apnea (SA), associated with absent neural output, is characterised by recurrent episodes of hypoxemia and repeated arousals during sleep, resulting in decreased sleep quality various health complications. Mitochondrial DNA copy number (mtDNA-CN), an easily accessible biomarker blood, reflects mitochondrial function. However, the causal relationship between mtDNA-CN SA remains unclear. This study aimed to investigate causality while identifying potential mediating brain imaging phenotypes (BIPs).

Язык: Английский

Процитировано

0