JAMA Network Open, Год журнала: 2024, Номер 7(11), С. e2445251 - e2445251
Опубликована: Ноя. 18, 2024
Ruixin Zhu, PhD; Ran Wang, Jingjing He, Langrun MSc; Huiyu Chen, Xiaokang Niu, You Sun, BSc; Yiran Guan, Yifan Gong, Liwei Zhang, Peng An, Keji Li, Fazheng Ren, Weili Xu, Jie Guo, PhD
Язык: Английский
JACC Asia, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 218, С. 111926 - 111926
Опубликована: Ноя. 12, 2024
Язык: Английский
Процитировано
5
Endocrine, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
Acute myocardial infarction (AMI) with cardiovascular-kidney-metabolic (CKM) condition is linked to a high in-hospital mortality. Some previous studies reported that calcium may be related mortality among patients AMI. However, there no report about the association between serum and AMI CKM syndrome. Therefore, this study investigated admission levels in cohort of This retrospective enrolled 2537 admitted including 270 CKM. All data were extracted from electronic medical records May 2019 April 2024. According reference range calcium, all divided into two groups, low group (0-2.10 mmol/L) non-low (from 2.11 mmol/L). The primary endpoint was rate significantly higher (16.8%, n = 19) compared (8.3%, 13). After adjusting for age, gender, hypertension, atrial fibrillation, stroke smoke, demonstrated (OR 2.409, 95% CI: 1.105-5.249, p < 0.05). In subgroup analyses, multivariable logistic regression models indicated an independent predictor females 7.453; CI 1.751-31.730; 0.05) elderly 3.122; 1.167-8.348; after adjustments smoke. Restricted cubic splines (RCS) analysis showed dose-response relationship (nonlinear P value 0.067). Admission hypocalcemia risk factor syndrome, especially individuals (aged ≥76 years) females.
Язык: Английский
Процитировано
0
Journal of the American Heart Association, Год журнала: 2024, Номер 13(16)
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
4
The American Journal of Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
The journal of nutrition health & aging, Год журнала: 2025, Номер 29(4), С. 100504 - 100504
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
The journal of nutrition health & aging, Год журнала: 2025, Номер 29(5), С. 100520 - 100520
Опубликована: Фев. 21, 2025
Diet plays a critical role in human health and environmental sustainability, particularly cardiovascular, kidney, metabolic (CKM) diseases. However, the variations Planetary Health Index (PHDI) across populations, regions, over time, as well its association with CKM disease burdens, remain insufficiently explored. We assessed PHDI scores using data from 185 countries (1990-2018) Global Dietary Database, examining demographic characteristics temporal trends. The Burden of Disease Study was used to evaluate associations between including incidence, prevalence, mortality, disability-adjusted life years. syndrome defined by American Heart Association. Individual-level National Nutrition Examination Survey (NHANES) were also assess impact on risks mortality. From 1990 2018, while overall remained relatively stable sexes, composition shifted different age groups. In mean score 42.80 (95% uncertainty interval [UI] 42.49-46.50) for males 44.65 UI 44.53-47.82) females. Higher observed among females, older adults, urban residents, individuals higher education, those South Asia. Globally, consumption red/processed meat, saturated oils/trans fats, added sugars substantially exceeded EAT-Lancet Commission's reference values. generally associated lower although these varied subtype. individual-level analysis, 45,460 NHANES participants (weighted age: 47.21 years, 51.4% female), each 10-point increase linked 13.7% reduction stage 3/4 risk, an 11.1% 4 incidences mortality rates cardiovascular diseases, chronic kidney disease. significant changes occurred components PHDI, notable demographics region. may reduce warranting further investigation into specific subtypes.
Язык: Английский
Процитировано
0
Journal of the American Heart Association, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Background The association between DNA methylation age acceleration (DNAmAA) and cardiovascular‐kidney‐metabolic (CKM) syndrome stages long‐term mortality in the population with CKM remains unclear. Methods Results This cohort study included 1889 participants from National Health Nutrition Examination Survey (1999–2002) data. DNAmAA was calculated as residuals regression of on chronological age. primary outcome all‐cause mortality, cardiovascular noncardiovascular secondary outcomes. Proportional odds models assessed associations DNAmAAs stages, Cox proportional hazards estimated mortality. Significant were found advanced particularly for GrimAge2Mort (GrimAA) (odds ratio [OR], 1.547 [95% CI, 1.316–1.819]). Over an average follow‐up 14 years, 1015 deaths occurred. Each 5‐unit increase GrimAA associated a 50% (95% 1.39–1.63), 77% 1.46–2.15), 42% 1.27–1.59). With lowest tertile reference, highest showed hazard ratios 1.95 1.56–2.45) 3.06 2.13–4.40) 1.65 1.20–2.29) Mediation analysis indicated that mediates various exposures (including physical activity, Healthy Eating Index‐2015 score, hemoglobin A1c, etc.) Conclusions may serve valuable biomarker assessing risk individuals syndrome, thereby informing personalized management strategies.
Язык: Английский
Процитировано
0
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 18, 2024
Cardiovascular-kidney-metabolic (CKM) syndrome is characterized as a systemic disease resulting from the pathophysiological interplay among metabolic risk factors, chronic kidney (CKD), and cardiovascular (CVD). The Klotho protein may serve novel biomarker. However, utility of serum levels an indicator severity mortality in CKM remains uncertain. This study involved 9,871 participants National Health Nutrition Examination Survey (NHANES) conducted between 2007 2016. Serum were measured using enzyme-linked immunosorbent assay kit. optimal cutoff value was established through maximum Youden's index. Multivariable weighted regression models employed to calculate odds ratio hazard ratio, along with 95% confidence interval, evaluate association syndrome, well all-cause mortality. Additionally, receiver operating characteristic curve restricted cubic spline curves utilized assess predictive efficacy explore nonlinear relationships. After adjusting for potential confounding non-linear relationship seen protein, syndrome. In multivariable, piecewise logistic regression, when klotho less than 801, decreased increase (OR = 0.82, 95%CI 0.70, 0.96; p < 0.001). Furthermore, we observed greater 801 0.94, 0.89, 0.99; 0.035). U-shaped, while L-shaped. Specifically, low associated by 21% 76% patients demonstrated excellent both indicates that reliable indicators
Язык: Английский
Процитировано
2
JAMA Network Open, Год журнала: 2024, Номер 7(11), С. e2445251 - e2445251
Опубликована: Ноя. 18, 2024
Ruixin Zhu, PhD; Ran Wang, Jingjing He, Langrun MSc; Huiyu Chen, Xiaokang Niu, You Sun, BSc; Yiran Guan, Yifan Gong, Liwei Zhang, Peng An, Keji Li, Fazheng Ren, Weili Xu, Jie Guo, PhD
Язык: Английский
Процитировано
0