Aging at the Crossroads of Organ Interactions: Implications for the Heart DOI
Ilke Sen,

Natasha A. Trzaskalski,

Yung‐Ting Hsiao

и другие.

Circulation Research, Год журнала: 2025, Номер 136(11), С. 1286 - 1305

Опубликована: Май 22, 2025

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate aging through cellular senescence, tissue wasting, accelerated atherosclerosis, increased vascular stiffness, reduction in blood flow, leading to organ remodeling premature failure. This interorgan/tissue crosstalk aging-related dysfunction inflammation, senescence-associated secretome, metabolic mitochondrial changes resulting oxidative stress, microvascular dysfunction, reprogramming, fibrosis. may also underscore the rising incidence co-occurrence of multiorgan population. Examples include between lungs, kidneys, liver, muscles, brain, among others. However, this phenomenon present new translational opportunities for identifying diagnostic biomarkers define early risks gain mechanistic insights, help design precision-directed therapeutic interventions. Indeed, opens development targeting multiple organs simultaneously disrupt crosstalk-driven process mutual disease acceleration. New targets could provide synergistic benefits across systems same at-risk patient. Ultimately, these approaches together slow itself throughout body. In future, with patient-centered multisystem coordinated approaches, we initiate a paradigm risk prediction tailored intervention. With emerging tools including artificial intelligence–assisted profiling novel preventive strategies (eg, RNA-based therapeutics), be able mitigate much earlier and, perhaps, even itself.

Язык: Английский

Aging at the Crossroads of Organ Interactions: Implications for the Heart DOI
Ilke Sen,

Natasha A. Trzaskalski,

Yung‐Ting Hsiao

и другие.

Circulation Research, Год журнала: 2025, Номер 136(11), С. 1286 - 1305

Опубликована: Май 22, 2025

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate aging through cellular senescence, tissue wasting, accelerated atherosclerosis, increased vascular stiffness, reduction in blood flow, leading to organ remodeling premature failure. This interorgan/tissue crosstalk aging-related dysfunction inflammation, senescence-associated secretome, metabolic mitochondrial changes resulting oxidative stress, microvascular dysfunction, reprogramming, fibrosis. may also underscore the rising incidence co-occurrence of multiorgan population. Examples include between lungs, kidneys, liver, muscles, brain, among others. However, this phenomenon present new translational opportunities for identifying diagnostic biomarkers define early risks gain mechanistic insights, help design precision-directed therapeutic interventions. Indeed, opens development targeting multiple organs simultaneously disrupt crosstalk-driven process mutual disease acceleration. New targets could provide synergistic benefits across systems same at-risk patient. Ultimately, these approaches together slow itself throughout body. In future, with patient-centered multisystem coordinated approaches, we initiate a paradigm risk prediction tailored intervention. With emerging tools including artificial intelligence–assisted profiling novel preventive strategies (eg, RNA-based therapeutics), be able mitigate much earlier and, perhaps, even itself.

Язык: Английский

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