Archives of Gerontology and Geriatrics, Год журнала: 2024, Номер 129, С. 105684 - 105684
Опубликована: Ноя. 12, 2024
There is a lack of information on the molecular mechanisms by which steroid hormones (testosterone, estrogen, and progesterone) regulate cognitive impairment. Thus, we aimed to identify protective effects function.
Язык: Английский
Circulation Research, Год журнала: 2024, Номер 134(6), С. 810 - 832
Опубликована: Март 14, 2024
Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of disease, role circadian biology has been relatively overlooked both preclinical models humans. Although presence daily patterns observed from level genome whole organism, functional structural impact biological rhythms, including such as misalignment, remains poorly defined. Here, we review rhythms systems regulating blood pressure onset, progression, consequences hypertension. There an emphasis on relation vascular end-organ effects that, individually or combination, contribute complex phenotypes cognitive decline loss cardiac brain health. effective treatment options some individuals, control inadequate substantial portion hypertensive population. Greater insight into may form foundation novel more widely molecular therapies interventions help prevention, treatment, management its related pathophysiology.
Язык: Английский
Процитировано
12
КАРДИОЛОГИЯ УЗБЕКИСТАНА, Год журнала: 2024, Номер 17(8), С. 961 - 978
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
12
BMC Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 10, 2024
Abstract Background The associations between trajectories of different health conditions and cognitive impairment among older adults were unknown. Our cohort study aimed to investigate the impact various trajectories, including sleep disturbances, depressive symptoms, functional limitations, multimorbidity, on subsequent risk impairment. Methods We conducted a prospective by using eight waves national data from Health Retirement Study (HRS 2002–2018), involving 4319 aged 60 years or in USA. Sleep disturbances symptoms measured Jenkins Scale Centers for Epidemiologic Research Depression (CES-D) scale, respectively. Functional limitations assessed activities daily living (ADLs) instrumental (IADLs), Multimorbidity status was self-reporting physician-diagnosed diseases. identified 8-year at four examinations 2002 2010 latent class trajectory modeling. screened participants 27-point HRS scale 2018 across waves. calculated hazard ratios (HR) Cox proportional models. Results During 25,914 person-years, 1230 developed In fully adjusted model 3, ADLs not associated with Compared low trajectory, we found that increasing (HR = 1.39; 95% CI 1.17–1.65), IADLs 1.88; 1.43–2.46), high multimorbidity 1.48; 1.16–1.88) all posed an elevated higher urban areas 2.30; 1.65–3.21) those who smoked 2.77; 1.91–4.02) (all P interaction < 0.05). Conclusions results suggest tracking functioning may be potential feasible screening method identifying
Язык: Английский
Процитировано
10
Neurology, Год журнала: 2025, Номер 104(8)
Опубликована: Март 26, 2025
Better cardiovascular health (CVH), measured using the Life's Simple 7 (LS7) score, is associated with improved cognitive function. However, its effect on brain imaging in Hispanics/Latinos has not been reported. We investigated association of LS7 score MRI outcomes a diverse Hispanic/Latino population. Hispanic Community Health Study/Study Latinos (HCHS/SOL) largest prospective cohort study adults United States. was assessed at baseline (2008-2011). The SOL-Investigation Neurocognitive Aging (SOL-INCA) ancillary recruited HCHS/SOL participants who underwent neuroimaging approximately 10 years (2017-2022) later. Main include standardized residuals for total brain, and lobar gray matter (frontal, temporal, parietal, occipital), white matter, CSF, lateral ventricle (LV), hyperintensity (WMH) volumes diffusion tensor (mean free water fraction, peak width skeletonized mean diffusivity, fractional anisotropy). across continuous scores were adjusted linear regression models. performed an interaction analysis by age sex. All analyses accounted complex sample design. included 2,659 (weighted %female = 56%). (95% CI) 54 (53-55) years, 7.2 (7.1-7.3). In fully model, higher larger (βTotal Brain 0.03 [0.002 to 0.06], βTotal White 0.05 [0.03 0.08], Gray 0.04 [0.01 βFrontal [0.02 0.07]); smaller CSF (β -0.06 [-0.08 -0.03]), LV -0.03 [-0.06 -0.004]), WMH -0.05 [-0.07 -0.03]) volumes; better measures microstructural integrity (βFW -0.002 [-0.003 -0.001], βPSMD -0.01 [-0.01 -0.003], βFA 0.001 [0.001 0.002]). age, benefits CVH magnetic resonance more pronounced older patients. No observed found that brain-based effects are dependent. Additional studies needed assess longitudinal MR-based outcomes.
Язык: Английский
Процитировано
1
Nature Reviews Neurology, Год журнала: 2024, Номер 20(11), С. 647 - 659
Опубликована: Окт. 7, 2024
Язык: Английский
Процитировано
5
Journal of Personalized Medicine, Год журнала: 2025, Номер 15(2), С. 57 - 57
Опубликована: Янв. 30, 2025
Background/Objectives: Cognitive impairment is a debilitating comorbidity affecting diverse patient populations, yet the cognitive effects of therapies like mineralocorticoid receptor antagonists (MRAs) remain underexplored. Preclinical evidence suggests that MRAs, particularly spironolactone, may reduce decline by modulating aldosterone-dependent pathways and targeting hippocampal receptors. However, in humans fragmented, no systematic review has consolidated these findings. This evaluates synthesizes current data, identifies research gaps. Methods: A literature search using terms related to MRAs outcomes was performed PubMed Web Science from 1979 2023. total 143 articles were identified 85 screened after removing duplicates. Ultimately, 44 studies included classified based on study design population focus (preclinical, healthy controls, patients with psychiatric disorders, cardiovascular patients). Results: Spironolactone demonstrated mixed cognition. In participants, it improved spatial memory under stress prevented stress-related suppression medial temporal activity, but impaired working selective attention. conditions, spironolactone reduced empathy deficits major depressive disorder bipolar I disorder. patients, scores had effect non-hippocampal memory. Conclusions: exhibits potential benefits across populations. its cognition are mixed, highlighting need for further understand mechanisms therapeutic potential, heart failure other conditions.
Язык: Английский
Процитировано
0
BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 5, 2025
Cardiovascular diseases (CVDs) marked with cardiac morphological or hemodynamical abnormalities are associated mild cognitive impairment (MCI). The links between structure and function MCI not well understood. We aimed to explore the association echocardiographic parameters of in CVD patients. conducted an age-, gender-, education level-matched case–control study general participants a 1:3 ratio (Montreal Cognitive Assessment [MoCA] score < 26 Mini-Mental State Examination [MMSE] ≥ 24) cognitively normal at tertiary hospital Beijing, China. status were retrieved through clinical electronic database from May 2021 August 2023. Principal component analysis (PCA), negative binomial, conditional multivariate regression performed. A total 1136 (mean age, 61.2 ± 8.3 years) included study, comprising 289 (25.3%) 847 participants. Compared participants, had higher prevalence left ventricular (LV) diastolic dysfunction (54.0% vs. 40.3%; P 0.001) greater interventricular septal thickness (IVST) (1.04 0.20 cm 1.00 0.17 cm; = 0.002). LV (Beta [SE], 0.234 [0.045]; IVST 0.034 [0.016]; 0.036) negatively correlated MoCA global function. (OR, 2.03; 95% CI, 1.48–2.79; 1.14; 1.03–1.27; 0.014) positively MCI, independent diagnosed CVDs conventional risk factors. General patients abnormal decline, suggesting further assessment for MCI. Retrospectively registered.
Язык: Английский
Процитировано
0
Journal of Cardiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Physiology & Behavior, Год журнала: 2025, Номер unknown, С. 114861 - 114861
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Analytics, Год журнала: 2025, Номер 4(1), С. 8 - 8
Опубликована: Март 4, 2025
This study explores the role of cognitive performance in general health older Europeans aged 50 and over, focusing on gender differences, using data from 336,500 respondents sixth wave Survey Health, Aging, Retirement Europe (SHARE). Cognitive functioning was assessed through self-rated reading writing skills, orientation time, numeracy, memory, verbal fluency, word-list learning. General status estimated by constructing a composite index physical mental health-related measures, including chronic diseases, mobility limitations, depressive symptoms, self-perceived health, Global Activity Limitation Indicator. Participants were classified into good or poor status, logistic regression models predictive significance variables supplemented relative importance analysis to estimate effect sizes. The results indicated that males had 51.1% lower risk reporting than females, age associated with 4.0% increase odds worse for both genders. Memory strongest predictor (26% model R2), greater contribution other variables. No significant differences found. While this estimates poorer relation various characteristics, adopting lifespan approach could provide valuable insights longitudinal associations between outcomes.
Язык: Английский
Процитировано
0