Neural Regeneration Research, Год журнала: 2024, Номер 20(11), С. 3213 - 3214
Опубликована: Окт. 22, 2024
Язык: Английский
Neurotherapeutics, Год журнала: 2024, Номер 21(3), С. e00337 - e00337
Опубликована: Фев. 19, 2024
Stroke is one of the most common and debilitating neurological conditions worldwide. Those who survive experience motor, sensory, speech, vision, and/or cognitive deficits that severely limit remaining quality life. While rehabilitation programs can help improve patients' symptoms, recovery often limited, patients frequently continue to impairments in functional status. In this review, invasive neuromodulation techniques augment effects conventional methods are described, including vagus nerve stimulation (VNS), deep brain (DBS) brain-computer interfaces (BCIs). addition, evidence base for each these techniques, pivotal trials, future directions explored. Finally, emerging technologies such as near-infrared spectroscopy (fNIRS) shift artificial intelligence-enabled implants wearables examined. field implantable devices chronic stroke still a nascent stage, data reviewed suggestive immense potential reducing impact impairment from globally prevalent disorder.
Язык: Английский
Процитировано
14
Journal of Neurorestoratology, Год журнала: 2025, Номер unknown, С. 100209 - 100209
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Авг. 16, 2024
Background Transcutaneous Vagal Nerve Stimulation (tVNS) has been used as a promising noninvasive neuromodulation technique for the treatment of various systems.The aim this study was to analyze research hotspots and future directions tVNS in 21st century by using bibliometric methods. Methods The object literature related from Web Science database 2000 May 2024. In order measure number issuance, institutions, authors, countries, keywords, co-citations, journals publication, we VOSviewer, Citespace, Bibliometrix R-package, Scimago Graphica software. A narrative review current content conducted gain better understanding state field. Results total 569 papers were included study. results show that 2024, publications shows an increasing trend year year, involving 326 institutions. United States, China, Germany are major centers. identified 399 which roughly formed 11 natural clusters, revealing mainly reflected 3 areas: intervention efficacy on nervous system diseases, mechanism action tVNS, stimulation mode tVNS. top 10 most cited references focus into Conclusion safety have confirmed previous studies, but standardized protocol not yet developed, clinical studies small sample sizes lack multicenter multidisciplinary collaboration. Currently, is neurological psychiatric cardiovascular some autoimmune diseases. It expected field will continue application central diseases exploration mechanisms, at same time, with rise non-invasive technology, other also great potential development.
Язык: Английский
Процитировано
4
Bioelectronic Medicine, Год журнала: 2024, Номер 10(1)
Опубликована: Сен. 13, 2024
Abstract The identification of acute cardioprotective strategies against myocardial ischemia/reperfusion (I/R) injury that can be applied in the catheterization room is currently an unmet clinical need and several interventions evaluated past at pre-clinical level have failed translation. Autonomic imbalance, sustained by abnormal afferent signalling, a key component I/R injury. Accordingly, there strong rationale for neuromodulation strategies, aimed reducing sympathetic activity and/or increasing vagal tone, this setting. In review we focus on cervical nerve stimulation (cVNS) transcutaneous auricular vagus (taVNS); latest has potential to overcome issues invasive cVNS, including possibility being used setting, while retaining its beneficial effects. First, discuss pathophysiology injury, mostly consequence overproduction reactive oxygen species. Second, describe functional anatomy parasympathetic branch autonomic nervous system most relevant principles bioelectronic medicine electrical modulation, with particular taVNS. Then, provide detailed comprehensive summary studies non-invasive VNS support effect whenever or chronic cardiac specifically setting benefit emerging field post arrest syndrome (PCAS) also mentioned. Indeed, cVNS anti-adrenergic, anti-inflammatory, antioxidants, anti-apoptotic pro-angiogenic effect; involved molecular pathways were already directly confirmed take place Pre-clinical data clearly show sooner applied, better outcome, marked infarct size reduction almost complete left ventricular reverse remodelling when immediately before during reperfusion. Finally, detail limited but very promising experience taVNS available so far.
Язык: Английский
Процитировано
4
BMJ Open, Год журнала: 2025, Номер 15(3), С. e092520 - e092520
Опубликована: Март 1, 2025
Introduction Arm weakness after stroke is one of the leading causes adult-onset disability. Invasive vagus nerve stimulation (VNS) paired with rehabilitation has been shown to improve arm recovery in chronic stroke. Small studies non-invasive or transcutaneous VNS (tVNS) suggest it safe and tolerable. However, not known whether tVNS effective promoting what mechanisms action are. Methods analysis TRICEPS a UK multicentre, double-blinded, superiority, parallel-group, three-arm two-stage an option select promising arm(s) at 50% accrual, individually randomised, sham-controlled trial. Up 243 participants will be randomised (1:1:1) using minimisation via restricted, web-based centralised system. delivered by movement-activated system (TVNS Technologies), which delivers during repetitive task practice. Rehabilitation consist training for 1 hour day, 5 days per week 12 weeks. Participants adults anterior circulation ischaemic between 6 months 10 years prior moderate-severe weakness. The primary outcome measure change Upper Limb Fugl-Meyer total motor score 91 start treatment. Secondary measures include Wolf Motor Function Test, Modified Ashworth Scale assess spasticity affected Stroke-Specific Quality Life Scale. A mechanistic substudy including 40 explore active versus sham multimodal MRI serum inflammatory cytokine levels. Participant recruitment started on 30 November 2023. Ethics dissemination study received ethical approval from Cambridge Central Research Committee (REC reference: 22/NI/0134). Dissemination results publications scientific journals, meetings, written reports articles stakeholder publications. Trial registration number NCT20221867 .
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 159, С. 114941 - 114941
Опубликована: Май 28, 2025
Язык: Английский
Процитировано
0
Neurological Sciences, Год журнала: 2025, Номер unknown
Опубликована: Июнь 2, 2025
Abstract Background Stroke is a leading cause of adult-onset disability. Non-invasive brain stimulation (NIBS) techniques such as transcranial magnetic (TMS), direct current (tDCS), and transcutaneous vagus nerve (tVNS) may improve arm weakness after stroke. Resting-state functional MRI (rs-fMRI) near-infrared spectroscopy (rs-fNIRS) assess connectivity. Identifying the effect NIBS on rs-fMRI/rs-fNIRS illuminate post-stroke recovery process. This systematic review assesses effects clinical outcomes in stroke survivors with weakness. Methods Systematic searches were conducted EMBASE MEDLINE. Articles involving adults from stroke, treated more than one session (TMS/tDCS/tVNS) reporting at baseline post-intervention included. The Cochrane Risk Bias tool was used to methodological quality included studies. Data extraction narrative synthesis performed. Results Twelve articles containing 393 participants Nine studies assessed TMS, two tDCS, study dual-mode (TMS tDCS). All showed significant improvements measures function compared following NIBS. changes connectivity post-intervention. Enhanced interhemispheric connectivity, particularly between primary motor cortices, positively correlated outcomes. Discussion Both TMS tDCS are promising adjunctive therapies for post-stroke. Rs-fMRI, provide valid biomarker restitution Future research should involve.
Язык: Английский
Процитировано
0
Stroke, Год журнала: 2023, Номер 55(2), С. 519 - 522
Опубликована: Дек. 14, 2023
Implantable vagus nerve stimulation, paired with high-dose occupational therapy, has been shown to be effective in improving upper limb function among patients stroke and received regulatory approval from the US Food Drug Administration Centers for Medicare & Medicaid Services. Combining nonsurgical surgical approaches of stimulation recent meta-analyses resulted misleading reports on efficacy each type stroke. This article aims clarify confusion surrounding implantable as a poststroke treatment option, highlighting importance distinguishing between transcutaneous auricular stimulation. Recent have inappropriately combined studies fundamentally different interventions, outcome measures, participant selection, which do not conform methodological best practices and, hence, cannot used deduce relative types rehabilitation. Health care providers, patients, insurers should rely appropriately designed research guide well-informed decisions.
Язык: Английский
Процитировано
8
IEEE Journal of Biomedical and Health Informatics, Год журнала: 2023, Номер 28(3), С. 1285 - 1296
Опубликована: Дек. 18, 2023
Motor learning plays a crucial role in human life, and various neuromodulation methods have been utilized to strengthen or improve it. Transcutaneous auricular vagus nerve stimulation (taVNS) has gained increasing attention due its non-invasive nature, affordability ease of implementation. Although the potential taVNS on regulating motor suggested, actual regulatory effect yet fully explored. Electroencephalogram (EEG) analysis provides an in-depth understanding cognitive processes involved so as offer methodological support for regulation learning. To investigate learning, this study recruited 22 healthy subjects participate single-blind, sham-controlled, within-subject serial reaction time task (SRTT) experiment. Every subject two sessions at least one week apart received 20-minute active/sham each session. Behavioral indicators well EEG characteristics during state, were extracted analyzed. The results revealed that compared sham group, active group showed higher performance. Additionally, indicated after taVNS, motor-related cortical amplitudes alpha-gamma modulation index decreased significantly functional connectivity based partial directed coherence towards frontal lobe was enhanced. These findings suggest can mainly through enhancing memory functions rather than simple movement This confirms positive which is particularly promising it offers avenue skills facilitating rehabilitation.
Язык: Английский
Процитировано
5
Brain & Neurorehabilitation, Год журнала: 2024, Номер 17(1)
Опубликована: Янв. 1, 2024
Stroke is a leading global cause of death and disability, with motor impairment being one the common post-stroke complications. Rehabilitation crucial for functional recovery. Recently, non-invasive brain stimulation (NIBS) has emerged as promising intervention that allows neuromodulation by activating or inhibiting neural activity in specific regions. This narrative review aims to examine current research on effects various NIBS techniques, including repetitive transcranial magnetic stimulation, direct vagus nerve focused ultrasound function.
Язык: Английский
Процитировано
1