Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 15, 2024

Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting healthy aging. This study aims to (i) identify the sleep duration trend US adults; (ii) investigate relationship between and phenotypic age; (iii) explore role of exercise this relationship. Phenotypic age as novel index was calculated according biomarkers collected from adults based on National Health Nutrition Examination Survey (NHANES). information self-reported by participants discerned through individual interviews. The principal analytical method employed weighted multivariable linear regression modeling, which accommodated for complex multi-stage sampling design. potential non-linear explored using restricted cubic spline (RCS) model. Furthermore, subgroup analyses evaluated effects sociodemographic lifestyle factors primary outcomes. A total 13,569 were finally included in, thereby resulting population 78,880,615. An examination temporal trends revealed declining proportion individuals with insufficient markedly deficient time since 2015-2016 cycle. Taken normal group reference, extreme short [β (95% CI) 0.582 (0.018, 1.146), p = 0.044] long 0.694 (0.186, 1.203), 0.010] both positively associated fully adjusted According dose-response age, benefit regular activity, whereas more tended have higher age. There an inverted U-shaped durations represents important step forward our understanding By shedding light topic providing practical recommendations habits, researchers help live longer, healthier, fulfilling lives.

Язык: Английский

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Review—Smart Wearable Sensors for Health and Lifestyle Monitoring: Commercial and Emerging Solutions

ECS Sensors Plus, Год журнала: 2024, Номер 3(1), С. 017001 - 017001

Опубликована: Март 1, 2024

The rapid growth of urbanisation has brought about various health concerns for citizens living in urban environments. Sedentary lifestyles, increased pollution levels, and high levels stress have become prevalent issues affecting the overall well-being populations. In recent years, emergence smart wearable devices offered a promising avenue to address these promote healthier lifestyles. This review evaluatse effectiveness wearables mitigating improving lifestyles citizens. involves 50 relevant peer-reviewed studies supporting literature from electronic databases PubMed, Ovid, Web Science, Scopus. Results indicate that potential positively impact by promoting physical activity, tracking vital signs, monitoring sleep patterns, providing personalised feedback recommendations activity levels. Furthermore, can help individuals manage enhance self-awareness, foster behaviours. However, also identifies several challenges, including accuracy reliability data, user engagement adherence, ethical considerations regarding data privacy security.

Язык: Английский

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Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 753 - 753

Опубликована: Янв. 6, 2024

Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting profound questions about its implications for health disease. Among the contributing factors, one intriguing actor in this complex interplay is human cytomegalovirus (CMV), member of herpesvirus family. Latent CMV infection exerts influence on aging immune system, potentially to age-related diseases. review delves into intricate relationship between CMV, revealing how chronic viral impacts landscape. We explore mechanisms through which can impact composition functionality cell populations induce shifts inflammatory profiles aging. Moreover, we examine potential role pathologies such cardiovascular diseases, cancer, neurodegenerative disorders, COVID-19, Long COVID. underlines importance understanding CMV. It offers insights pathophysiology age-associated well COVID-19 outcomes among elderly. By unraveling connections gain deeper aging’s remarkable journey that infections play transforming system.

Язык: Английский

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Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?

Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 23, 2025

Cellular senescence is understood to be a biological process that defined as irreversible growth arrest and was originally recognized tumor-suppressive mechanism prevents further propagation of damaged cells. More recently, cellular has been shown have dual role in prevention tumor promotion. Senescent cells carry senescence-associated secretory phenotype (SASP), which altered by factors including pro-inflammatory cytokines, chemokines, other proteases, leading the alteration tissue microenvironment. Though would eventually halt cancerous potential cells, SASP contributes environment promoting inflammation, matrix remodeling, cell invasion. The paradox prevention/promotion particularly relevant bone niche microenvironment, where longer-lasting, chronic inflammation promotes formation. Insights into mechanistic understanding provide basis for targeted therapies, such senolytics, aim eliminate senescent or inhibitors, tumor-promoting effects senescence. These therapeutic interventions offer significant clinical implications treating cancer healthy aging.

Язык: Английский

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Liver Regeneration after Hepatectomy and Partial Liver Transplantation

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(21), С. 8414 - 8414

Опубликована: Ноя. 9, 2020

The liver is a unique organ with an abundant regenerative capacity. Therefore, partial hepatectomy (PHx) or transplantation (PLTx) can be safely performed. Liver regeneration involves complex network of numerous hepatotropic factors, cytokines, pathways, and transcriptional factors. Compared after viral- drug-induced injury, that post-PHx -PLTx has several distinct features, such as hemodynamic changes in portal venous flow pressure, tissue ischemia/hypoxia, hemostasis/platelet activation. Although some these also occur during they are more abrupt drastic following PHx PLTx, thus the main trigger driving force regeneration. In this review, we first provide overview molecular biology -PLTx. Subsequently, summarize clinical conditions negatively, sometimes positively, interfere marginal livers including aged fatty influence immunosuppression.

Язык: Английский

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Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

Nutrients, Год журнала: 2020, Номер 12(5), С. 1344 - 1344

Опубликована: Май 8, 2020

It has been thought that caloric restriction favors longevity and healthy aging where autophagy plays a vital role. However, decreases during can lead to the development of aging-associated diseases such as cancer, diabetes, neurodegeneration, etc. was shown be induced by mechanical or chemical stress. In this regard, various pharmacological compounds were proposed, including natural polyphenols. Apart from ability induce autophagy, polyphenols, resveratrol, are capable modulating expression pro- anti-apoptotic factors, neutralizing free radical species, affecting mitochondrial functions, chelating redox-active transition metal ions, preventing protein aggregation. Moreover, polyphenols have advantages compared inducers due their intrinsic bio-compatibility safety. context, considered potential therapeutic tool for either part diet separate (supplements). This review discusses epigenetic aspect underlying molecular mechanism an anti-aging remedy. addition, recent advances studies on NAD-dependent deacetylase sirtuin-1 (SIRT1) regulation role senescence-associated secretory phenotype (SASP) in cells senescence highlighted well. that, also revised latest information how help improve function modulate apoptosis (programmed cell death).

Язык: Английский

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Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence

Nutrients, Год журнала: 2021, Номер 13(12), С. 4550 - 4550

Опубликована: Дек. 18, 2021

The role of the microbiome in human aging is important: directly impacts through gastrointestinal system. However, microbial impact on skin has yet to be fully understood. For example, cellular senescence an intrinsic process that been recently associated with imbalance. With age, cells become senescent response stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. An accumulation linked various and chronic pathologies due overexpression senescence-associated secretory phenotype (SASP) comprised proinflammatory cytokines, chemokines, factors, proteases, lipids extracellular matrix components. In particular, dermatological disorders may promoted by as a common site accumulation. gut microbiota influences disruption gut-skin axis secretion metabolites. Metabolomics can used identify quantify metabolites involved senescence. Moreover, novel anti-senescent therapeutics are warranted given poor safety profiles current pharmaceutical drugs. Probiotics prebiotics effective alternatives, considering relationship between healthy aging. further research composition under status needed develop immunomodulatory therapies.

Язык: Английский

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Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

Advances in Therapy, Год журнала: 2020, Номер 37(4), С. 1407 - 1424

Опубликована: Март 17, 2020

Abstract Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in prevalence and burden of aging-associated diseases. Recent evidence proven that cellular senescence contributes development these disorders. Cellular is state cell cycle arrest with suppressed apoptosis concomitant secretion multiple bioactive factors (the senescence-associated secretory phenotype—SASP) plays physiological role embryonic healing processes. However, DNA damage oxidative stress occur during aging cause accumulation senescent cells, which through their SASP bring about deleterious effects on organ systemic functions. Ablation cells genetic or pharmacological means leads improved life span health animal models, preliminary suggests it may also have positive impact human health. Thus, strategies reduce eliminate products potential clinical outcomes single intervention. In this review, we touch upon basics summarize current therapies against for use.

Язык: Английский

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Telomere length: how the length makes a difference

Molecular Biology Reports, Год журнала: 2020, Номер 47(9), С. 7181 - 7188

Опубликована: Сен. 1, 2020

Abstract Telomerase is perceived as an immortality enzyme that might provide longevity to cells and whole organisms. Importantly, it generally inactive in most somatic of healthy, adult men. Consequently, its substrates, i.e. telomeres, get shorter human with time. Noteworthy, cell life limitation due telomere attrition during divisions, may not be bad looks since longer means exposition harmful factors. length (attrition rate) becomes a factor responsible for inducing the signaling leads elimination lived long enough acquire severe damage. It seems depends on many different factors (including telomerase activity but also genetic factors, hormonal profile reflects sex, etc.) become useful marker aging stress. Thus current paper, we review affect focusing sex all together environmental regulations well parental aspect rate. We raise some limitations assessment hinders trustworthy meta-analysis lead acknowledgment real value this parameter.

Язык: Английский

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Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

International Journal of Molecular Sciences, Год журнала: 2021, Номер 23(1), С. 48 - 48

Опубликована: Дек. 21, 2021

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and participates in control mRNA translation. Additionally, phospho (p)-RPS6 has been recognized as surrogate marker for activated PI3K/AKT/mTORC1 pathway, which occurs many cancer types. However, downstream mechanisms regulated by RPS6 or p-RPS remains elusive, therapeutic implication underappreciated despite an approximately half century history research on this protein. In addition, substantial evidence from knockdown experiments suggests potential role maintaining cell proliferation. This motivates us to investigate current knowledge functions cancer. review article, we reviewed information about transcriptional regulation, upstream regulators, extra-ribosomal roles RPS6, with focus its involvement We also discussed

Язык: Английский

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