Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 532 - 545
Опубликована: Авг. 1, 2024
Язык: Английский
The Innovation, Год журнала: 2025, Номер 6(2), С. 100755 - 100755
Опубликована: Янв. 6, 2025
Chimpanzees (Pan troglodytes) are one of humans' closest living relatives, making them the most directly relevant comparison point for understanding human brain evolution. Zeroing in on differences connectivity between humans and chimpanzees can provide key insights into specific evolutionary changes that might have occurred along lineage. However, such comparisons hindered by absence cross-species atlases established within same framework. To address this gap, we developed Chimpanzee Brainnetome Atlas (ChimpBNA) using a connectivity-based parcellation Leveraging new resource, found substantial divergence patterns two species across association cortices, notably lateral temporal dorsolateral prefrontal cortex. These deviate sharply from pattern cortical expansion observed when comparing to chimpanzees, highlighting more complex nuanced evolution than previously recognized. Additionally, identified regions displaying connectional asymmetries differed species, likely resulting divergence. Genes highly expressed divergent connectivities were enriched cell types crucial projection circuits synapse formation, whose pronounced expression hint at genetic influences neural circuit development, function, Our study provides fine-scale chimpanzee atlas highlights chimpanzee-human rigorous comparative manner. In addition, these results suggest potential gene correlates species-specific linking neuroimaging data, offering human-unique cognitive capabilities.
Язык: Английский
Процитировано
2
Progress in Neurobiology, Год журнала: 2024, Номер 239, С. 102633 - 102633
Опубликована: Июнь 1, 2024
The somatosensory cortex is a brain region responsible for receiving and processing sensory information from across the body structurally functionally heterogeneous. Since chemoarchitectonic segregation of cerebral can be revealed by transmitter receptor distribution patterns, using quantitative multireceptor architectonical analysis, we determined number extent distinct areas macaque cortex. We identified three architectonically cortical entities within primary (i.e., 3bm, 3bli, 3ble), four anterior parietal 3am, 3al, 1 2) six subdivisions S2l, S2m, PVl, PVm, PRl PRm) lateral fissure. provide an ultra-high resolution 3D atlas in stereotaxic space, which integrates cyto- architectonic features areas. Multivariate analyses fingerprints clusters based on degree (dis)similarity their architecture. Each these associated with levels processing, further demonstrating that functional underpinned differences molecular organization.
Язык: Английский
Процитировано
3
Frontiers in Neuroinformatics, Год журнала: 2024, Номер 18
Опубликована: Фев. 9, 2024
Neuroscientists employ a range of methods and generate increasing amounts data describing brain structure function. The anatomical locations from which observations or measurements originate represent common context for interpretation, starting point identifying interest. However, the multimodality abundance pose challenge efforts to organize, integrate, analyze based on locations. While structured metadata allow faceted queries, different types are not easily represented in standardized machine-readable way that comparison, analysis, queries related relevance. To this end, three-dimensional (3D) digital atlases provide frameworks disparate multimodal multilevel neuroscience can be spatially represented. We propose as geometric objects 3D atlases. Such specified file format stored location use with computational tools. here present Locare workflow developed defining elements rodent brains objects. demonstrate how used define representing experimental rat mouse further collection JSON schemas (LocareJSON) specifying by atlas coordinates, suitable co-visualization an enabling spatial queries.
Язык: Английский
Процитировано
2
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 532 - 545
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
0