Intrinsic functional connectivity among memory networks does not predict individual differences in narrative recall

Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 17

Опубликована: Апрель 23, 2024

Abstract Individuals differ greatly in their ability to remember the details of past events, yet little is known about brain processes that explain such individual differences a healthy young population. Previous research suggests episodic memory relies on functional communication among ventral regions default mode network (“DMN-C”) are strongly interconnected with medial temporal lobes. In this study, we investigated whether intrinsic connectivity DMN-C subnetwork related ability, examining relationship across 243 individuals (ages 18-50 years) from openly available Cambridge Center for Aging and Neuroscience (Cam-CAN) dataset. We first estimated each participant’s whole-brain by combining data resting-state, movie-watching, sensorimotor task scans increase statistical power. then examined predicted performance narrative recall task. found no evidence DMN-C, itself, other DMN subnetworks, or rest brain, was recall. Exploratory connectome-based predictive modeling (CBPM) analyses entire connectome revealed multivariate pattern performance, although these changes were largely outside networks. These results add emerging suggesting cannot be easily explained areas typically associated function.

Язык: Английский

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Pathways to adolescent social anxiety: Testing interactions between neural social reward function and perceived social threat in daily life

Development and Psychopathology, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Май 27, 2024

Abstract Recent theories suggest that for youth highly sensitive to incentives, perceiving more social threat may contribute anxiety (SA) symptoms. In 129 girls (ages 11–13) oversampled shy/fearful temperament, we thus examined how interactions between neural responses reward (vs. neutral) cues (measured during anticipation of peer feedback) and perceived in daily using ecological momentary assessment) predict SA symptoms two years later. No significant emerged when function was modeled as a latent factor. Secondary analyses showed higher associated with severe later only basolateral amygdala (BLA) activation at baseline. Interaction effects were specific BLA (not threat) cues, though main effect on emerged. Unexpectedly, also predicted generalized depression later, suggesting possible transdiagnostic risk pathways. Perceiving high be particularly detrimental potentially due mediating learning processes, this remains tested.

Язык: Английский

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Pathways to adolescent social anxiety: Testing interactions between neural social reward function and perceived social threat in daily life

Опубликована: Фев. 29, 2024

Recent theories suggest that for youth highly sensitive to incentives, perceiving more social threat may contribute anxiety (SA) symptoms. In 129 girls (ages 11-13) oversampled shy/fearful temperament, we thus examined how interactions between neural responses reward (vs. neutral) cues (measured during anticipation of peer feedback) and perceived in daily using ecological momentary assessment) predict SA symptoms two years later. No significant emerged when function was modeled as a latent factor. Secondary analyses showed higher associated with severe later only basolateral amygdala (BLA) activation at baseline. Interaction effects were specific BLA (not threat) cues, though main effect on emerged. Unexpectedly, also predicted generalized depression later, suggesting possible transdiagnostic risk pathways. Perceiving high be particularly detrimental potentially due mediating learning processes, this remains tested.

Язык: Английский

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Intrinsic functional connectivity among memory networks does not predict individual differences in narrative recall

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 3, 2023

Individuals differ greatly in their ability to remember the details of past events, yet little is known about brain processes that explain such individual differences a healthy young population. Previous research suggests episodic memory relies on functional communication among ventral regions default mode network ("DMN-C") are strongly interconnected with medial temporal lobes. In this study, we investigated whether intrinsic connectivity DMN-C subnetwork related ability, examining relationship across 243 individuals (ages 18-50 years) from openly available Cambridge Center for Aging and Neuroscience (Cam-CAN) dataset. We first estimated each participant's whole-brain by combining data resting-state, movie-watching, sensorimotor task scans increase statistical power. then examined predicted performance narrative recall task. found no evidence DMN-C, itself, other DMN subnetworks, or rest brain, was recall. Exploratory connectome-based predictive modeling (CBPM) analyses entire connectome revealed multivariate pattern performance, although these changes were largely outside networks. These results add emerging suggesting cannot be easily explained areas typically associated function.

Язык: Английский

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