Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Фев. 19, 2025
Cognitive
impairment
is
a
common
dysfunction
following
stroke,
significantly
affecting
patients'
quality
of
life.
Studies
suggest
that
post-stroke
cognitive
(PSCI)
may
be
related
to
neural
activity
in
specific
brain
regions.
However,
the
mechanisms
remain
further
explored.
This
study
aimed
investigate
alterations
function
patients
with
PSCI.
was
case-control
study.
Thirty
PSCI,
thirty
non-PSCI
(NPSCI),
and
age-
gender-matched
healthy
controls
(HCs)
were
selected
1:1:1
ratio.
Resting-state
functional
magnetic
resonance
imaging
(rs-fMRI)
acquired
from
all
participants
potential
PSCI
by
comparing
differences
fractional
amplitude
low-frequency
fluctuation
(fALFF),
Kendall's
coefficient
concordance-regional
homogeneity
(KCC-ReHo),
seed-based
connectivity
(FC).
Additionally,
Montreal
Assessment
(MoCA)
scores
collected,
Pearson
correlation
used
analyze
between
indicators
performance
patients.
fALFF
analysis
revealed
group
had
decreased
zfALFF
values
left
caudate,
right
inferior
temporal
gyrus
(ITG),
anterior
cingulate
cortex
(ACC),
putamen,
superior
gyrus.
In
contrast,
increased
observed
Cerebellum_6.
KCC-ReHo
indicated
SzKCC-ReHo
middle
frontal
(MFG)
postcentral
lobe,
while
cerebellum_
crus
1,
cerebellum_4-5.
Furthermore,
FC
zFC
regions
group,
especially
angular
precuneus.
showed
value
ACC
positively
correlated
MoCA
group.
demonstrated
significant
changes
spontaneous
intensity,
regional
homogeneity,
multiple
cognition-related
patients,
shedding
light
on
underlying
Язык: Английский
Age Differences in Brain Functional Connectivity Underlying Proactive Interference in Working Memory
Human Brain Mapping,
Год журнала:
2025,
Номер
46(5)
Опубликована: Апрель 1, 2025
ABSTRACT
Aging
is
typically
accompanied
by
a
decline
in
working
memory
(WM)
capacity,
even
the
absence
of
pathology.
Proficient
WM
requires
cognitive
control
processes
that
can
retain
goal‐relevant
information
for
easy
retrieval
and
resolve
interference
from
irrelevant
information.
has
been
associated
with
reduced
ability
to
proactive
(PI)
WM,
leading
impaired
It
remains
unclear
how
age‐related
differences
PI
are
related
patterns
resting‐state
functional
connectivity
(rsFC)
brain.
Here,
we
investigated
association
between
rsFC
cross‐sectionally
(
n
=
237)
5
years
longitudinally
134)
across
adult
life
span
employing
both
seed‐based
data‐driven
approaches.
Results
revealed
was
differential
inferior
frontal
gyrus
(IFG)
younger/middle‐aged
adults
(25–60
years)
older
(65–80
two
clusters
centered
vermis
caudate.
Specifically,
more
stronger
gyrus—vermis
weaker
gyrus—caudate
adults,
while
showed
associations
opposite
directions
identified
clusters.
Longitudinal
analyses
gyrus—insula
gyrus—anterior
cingulate
cortex
direction
these
Whole
brain
multivariate
pattern
age‐differential
indicative
structural
compensation.
The
current
results
show
modulated
age.
Язык: Английский