Connectivity of the neuronal network for contextual fear memory is disrupted in a mouse model of third‐trimester binge‐like ethanol exposure

Alcohol Clinical and Experimental Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract Background In rodents, third‐trimester‐equivalent alcohol exposure ( TTAE ) produces significant deficits in hippocampal‐dependent memory processes such as contextual fear conditioning CFC ). The present study sought to characterize changes both behavior and Fos + neurons following ethanol EtOH )‐treated versus saline‐treated mice using TRAP2 :Ai14 that permanently label a tamoxifen injection. We hypothesized would produce long‐lasting disruptions the networks engaged with particular emphasis on limbic system. Methods On postnatal day 7, received either two injections of saline or 2.5 g/kg spaced 2 h apart. were left undisturbed until they reached adulthood, at which point underwent . After context 2, Brain tissue was harvested. Slides automatically imaged Zeiss AxioScanner Manual counts priori regions interest conducted. Automated performed whole brain QUINT 2D stitching pipeline. Last, novel network analyses applied identify future interest. Results reduced recall neural density increased CA1 CA3 anteroventral AV anterodorsal thalamus. system showed hyperconnectivity male mice, shifted affinity toward hippocampal subregions. subparafascicular area basomedial amygdalar nucleus implicated important mediators. Discussion These results suggest is mediated by disrupted Given increase activity, potential hypothesis causes encoding 1 conditioning. Future studies will aim determine whether this disruption specifically affects retrieval memories.

Язык: Английский

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Neural Networks of Attention

Опубликована: Янв. 1, 2024

Язык: Английский

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Working Memory

Опубликована: Янв. 1, 2024

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