Restorative Neurology and Neuroscience,
Год журнала:
2023,
Номер
41(3-4), С. 129 - 191
Опубликована: Янв. 1, 2023
Background:
Aphasia
is
a
debilitating
language
impairment,
affecting
millions
of
people
worldwide.
About
40%
stroke
survivors
develop
chronic
aphasia,
resulting
in
life-long
disability.
Objective:
This
review
examines
extrinsic
and
intrinsic
neuromodulation
techniques,
aimed
at
enhancing
the
effects
speech
therapies
with
aphasia.
Methods:
We
discuss
available
evidence
supporting
use
transcranial
direct
current
stimulation
(tDCS),
repetitive
magnetic
stimulation,
functional
MRI
(fMRI)
real-time
neurofeedback
aphasia
rehabilitation.
Results:
systematically
evaluates
studies
focusing
on
efficacy
implementation
specialized
methods
for
post-treatment
outcome
optimization
transfer
to
skills.
It
considers
target
determination
various
targeting
approaches.
The
translation
interventions
clinical
practice
explored,
emphasizing
generalization
communication.
also
covers
fMRI
neurofeedback,
discussing
essential
parameters.
Finally,
we
address
future
directions
research
Conclusions:
comprehensive
aims
serve
as
resource
broad
audience
researchers
clinicians
interested
incorporating
advancing
care.
Neurobiology of Language,
Год журнала:
2021,
Номер
2(2), С. 202 - 225
Опубликована: Янв. 1, 2021
In
this
study,
we
investigated
how
the
brain
responds
to
task
difficulty
in
linguistic
and
non-linguistic
contexts.
This
is
important
for
interpretation
of
functional
imaging
studies
neuroplasticity
post-stroke
aphasia,
because
inherent
matching
or
controlling
with
neurological
populations.
Twenty
neurologically
normal
individuals
were
scanned
fMRI
as
they
performed
a
task,
each
which
had
two
levels
difficulty.
Critically,
tasks
matched
across
domains
(linguistic,
non-linguistic)
accuracy
reaction
time,
such
that
differences
between
easy
difficult
conditions
equivalent
domains.
We
found
demand
modulated
same
set
multiple
(MD)
regions
have
been
identified
many
prior
studies.
contrast,
MD
much
lesser
extent,
especially
nodes
belonging
dorsal
attention
network.
Linguistic
subset
language
regions,
left
inferior
frontal
gyrus
most
strongly
modulated.
The
right
hemisphere
region
homotopic
Broca's
area
was
also
by
but
not
demand.
When
mapped
relative
demand,
observed
domain
interactions
temporal
well
widespread
bilateral
semantic
sum,
strikingly
different
neural
correlates.
These
findings
can
be
used
better
interpret
patients
recovering
from
aphasia.
Some
reported
activations
these
may
reflect
performance
differences,
while
others
more
confidently
attributed
neuroplasticity.
Brain Communications,
Год журнала:
2022,
Номер
4(5)
Опубликована: Сен. 1, 2022
The
association
between
age
and
language
recovery
in
stroke
remains
unclear.
Here,
we
used
neuroimaging
data
to
estimate
brain
age,
a
measure
of
structural
integrity,
examined
the
extent
which
at
onset
is
associated
with
(i)
cross-sectional
performance,
(ii)
longitudinal
function,
beyond
chronological
alone.
A
total
49
participants
(age:
65.2
±
12.2
years,
25
female)
underwent
routine
clinical
(T1)
bedside
evaluation
performance
(Bedside
Evaluation
Screening
Test-2)
left
hemisphere
stroke.
Brain
was
estimated
from
enantiomorphically
reconstructed
scans
using
machine
learning
algorithm
trained
on
large
sample
healthy
adults.
subsample
30
returned
for
follow-up
assessments
least
2
years
after
onset.
To
account
variability
stroke,
calculated
proportional
difference,
i.e.
difference
age.
Multiple
regression
models
were
constructed
test
effects
outcomes.
Lesion
volume
included
as
covariates
all
models.
Accelerated
compared
worse
overall
aphasia
severity
(F(1,
48)
=
5.65,
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 15, 2024
Abstract
Recent
research
found
a
distinct
dissociation
between
brain
regions
supporting
domain-general
cognitive
processes
and
core
language
functions.
The
question
of
whether
individuals
with
post-stroke
aphasia
(IWA)
exhibit
comparable
remains
debated,
particularly
as
previous
studies
overlooked
individual
variability
in
functional
network
organization
heterogeneity.
To
address
this
gap,
we
employed
an
individualized
localization
approach
to
test
the
involvement
multiple
demand
(MD)
during
processing
chronic
aphasia.
We
collected
MRI
data
15
IWA
13
age-matched
controls.
Participants
performed
spatial
working
memory
task,
triggering
MD
activation,
well
listening
reading
activation.
compared
both
groups
activation
patterns
investigated
link
severity.
Involvement
was
examined
by
investigating
task
activity
within
subject-specific
that
are
active
task.
each
generalized
across
different
modalities,
but
exhibited
robust
from
other
groups.
Moreover,
there
no
evidence
either
group.
Additionally,
showed
weaker
controls
left-hemispheric
regions,
higher
values
left
correlating
improved
performance
IWA.
In
conclusion,
our
findings
suggest
does
not
contribute
passive,
receptive
functions
or
healthy
older
adults.
Instead,
results
align
proposing
normalized
supports
NeuroImage,
Год журнала:
2025,
Номер
310, С. 121112 - 121112
Опубликована: Март 4, 2025
Brain
tumors
provide
unique
insights
into
brain
plasticity
due
to
their
slow
growth
compared
acute
cerebrovascular
diseases.
Despite
relying
on
sophisticated
functional
networks,
patients
with
exhibit
minimal
deficits
in
higher
language
functions
and
demonstrate
positive
post-injury
plasticity;
however,
the
underlying
neural
mechanisms
remain
unclear.
We
utilized
high-density
electroencephalography
investigate
network
tumor
without
evident
deficits.
Natural
rhythmic
sentences
non-rhythmic
contrasting
speech
prosodic
harmony
were
employed
examine
impact
of
task
integrativeness
reorganization.
Our
study
reveals
that
perception,
characterized
by
processing
integrativeness,
induced
inhibited
engagement
frontal
lobe
but
evoked
enhanced
hubness
modularity,
which
supported
generation
new
connections
promoted
efficiency
global
connectivity.
Furthermore,
local
invasion
prompted
adjacent
hubs
generate
enriched
during
early
phase,
facilitating
later
findings
underscore
significant
role
reveal
importance
highly
integrated
tasks
for
reorganization
rehabilitation.
Frontiers in Human Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Май 11, 2023
Aphasia
is
a
common
complication
of
stroke
and
associated
with
high
morbidity
mortality
rates.
Rehabilitation
plays
crucial
role
in
the
comprehensive
management
post-stroke
aphasia
its
consequences.
However,
bibliometric
analysis
field
rehabilitation
still
lacking.
This
study
aimed
to
comprehensively
identify
assistance
networks,
analyze
research
trends,
focus
on
hot
cutting-edge
health
topics
related
rehabilitation,
inform
future
guidelines.The
Web
Science
Core
Collection
(WoSCC)
electronic
database
was
searched
from
inception
January
4,
2023
studies
rehabilitation.
Bibliometric
visualization
country,
institution,
journal,
author,
reference,
keywords
were
performed
using
CiteSpace
VOSviewer
software.A
total
2,325
papers
included
analysis,
progressive
increase
number
articles
published
each
year.
The
USA
country
most
publications
(809
articles),
University
Queensland
institution
(137
articles).
subject
area
dominated
by
clinical
neurology
(882
Aphasiology
journal
(254
articles)
cited
(6,893
citations).
Worrall
L
prolific
author
(51
publications),
Frideriksson
J
(804
citations).By
bibliometrics,
we
provided
review
Future
hotspots
will
mainly
plasticity
mechanisms
neurolinguistics
language
function
assessment,
modalities,
patients'
needs
participation
experiences
aphasia.
paper
provides
systematic
information
that
worth
exploring
future.
