The dynamic lung microbiome in health and disease

Nature Reviews Microbiology, Год журнала: 2022, Номер 21(4), С. 222 - 235

Опубликована: Ноя. 16, 2022

Язык: Английский

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Lung microbiome: new insights into the pathogenesis of respiratory diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Янв. 17, 2024

The lungs were long thought to be sterile until technical advances uncovered the presence of lung microbial community. microbiome healthy is mainly derived from upper respiratory tract (URT) but also has its own characteristic flora. selection mechanisms in lung, including clearance by coughing, pulmonary macrophages, oscillation cilia, and bacterial inhibition alveolar surfactant, keep transient mobile, which different other organs. bacteriome been intensively studied recently, relatively little research focused on mycobiome virome. This up-to-date review retrospectively summarizes microbiome's history, composition, function. We focus interaction with oropharynx gut emphasize role it plays innate adaptive immune responses. More importantly, we multiple diseases, asthma, chronic obstructive disease (COPD), fibrosis, bronchiectasis, pneumonia. impact coronavirus 2019 (COVID-19) cancer comprehensively studied. Furthermore, summarizing therapeutic potential diseases examining shortcomings field, propose an outlook direction research.

Язык: Английский

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Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 4051 - 4051

Опубликована: Апрель 5, 2024

Bacterial and viral respiratory tract infections are the most common infectious diseases, leading to worldwide morbidity mortality. In past 10 years, importance of lung microbiota emerged in context pulmonary although mechanisms by which it impacts intestinal environment have not yet been fully identified. On contrary, gut microbial dysbiosis is associated with disease etiology or/and development lung. this review, we present an overview microbiome modifications occurring during infections, namely, reduced community diversity increased burden, downstream consequences on host–pathogen interaction, inflammatory signals, cytokines production, turn affecting progression outcome. Particularly, focus role gut–lung bidirectional communication shaping inflammation immunity context, resuming both animal human studies. Moreover, discuss challenges possibilities related novel microbial-based (probiotics dietary supplementation) microbial-targeted therapies (antibacterial monoclonal antibodies bacteriophages), aimed remodel composition resident communities restore health. Finally, propose outlook some relevant questions field be answered future research, may translational relevance for prevention control infections.

Язык: Английский

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Critically evaluating the relative importance of phage in shaping microbial community composition

Trends in Microbiology, Год журнала: 2024, Номер 32(10), С. 957 - 969

Опубликована: Апрель 10, 2024

The ubiquity of bacteriophages (phages) and the major evolutionary ecological impacts they can have on their microbial hosts has resulted in phages often cited as key drivers shaping community composition (the relative abundances species). However, evidence for importance is mixed. Here, we critically review theory data exploring role communities, identifying conditions when are likely to be important composition. At scales, conclude that followers rather than population dynamics. While affect strain diversity within species, there yet strong suggesting fluctuations species' strains affects

Язык: Английский

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Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia

Nature Medicine, Год журнала: 2023, Номер 29(11), С. 2793 - 2804

Опубликована: Ноя. 1, 2023

Язык: Английский

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Early-life respiratory infections and developmental immunity determine lifelong lung health

Nature Immunology, Год журнала: 2023, Номер 24(8), С. 1234 - 1243

Опубликована: Июль 6, 2023

Язык: Английский

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Airway ‘Resistotypes’ and Clinical Outcomes in Bronchiectasis

American Journal of Respiratory and Critical Care Medicine, Год журнала: 2024, Номер 210(1), С. 47 - 62

Опубликована: Янв. 25, 2024

Chronic infection and inflammation shapes the airway microbiome in bronchiectasis. Utilizing whole-genome shotgun metagenomics to analyze resistome provides insight into interplay between microbes, resistance genes, clinical outcomes.

Язык: Английский

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Rethinking bronchiectasis as an inflammatory disease

The Lancet Respiratory Medicine, Год журнала: 2024, Номер 12(11), С. 901 - 914

Опубликована: Июль 3, 2024

Язык: Английский

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Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease

American Journal of Respiratory and Critical Care Medicine, Год журнала: 2024, Номер 210(3), С. 298 - 310

Опубликована: Фев. 5, 2024

Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated decline relates to mucus properties and the microbiome COPD.

Язык: Английский

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Infection and the microbiome in bronchiectasis

European Respiratory Review, Год журнала: 2024, Номер 33(173), С. 240038 - 240038

Опубликована: Июль 1, 2024

Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant morbidity, underpinned a complex interplay between microbial dysbiosis immune dysregulation. The identification of distinct endophenotypes have refined our understanding its pathogenesis, including heterogeneous disease mechanisms that influence treatment prognosis responses. Next-generation sequencing (NGS) has revolutionised the way we view airway microbiology, allowing insights into “unculturable”. Understanding bronchiectasis microbiome through targeted amplicon and/or shotgun metagenomics provided key information on host immunity, central feature progression. rapid increase in translational clinical studies now provides scope for application precision medicine better efficacy interventions aimed at restoring balance modulating Holistic integration these driving an evolving paradigm shift bronchiectasis, which includes critical role unique with clinical, inflammatory, immunological metabolic factors. Here, review current state infection provide views future directions this field.

Язык: Английский

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