A novel PhoPQ-potentiated mechanism of colistin resistance impairs membrane integrity in Pseudomonas aeruginosa

Опубликована: Окт. 16, 2024

Polymicrobial communities are often recalcitrant to antibiotic treatment because interactions between different microbes can dramatically alter their responses and susceptibility antimicrobials. However, the mechanisms of evolving antimicrobial resistance in such polymicrobial environments poorly understood. We previously reported that Mg

Язык: Английский

Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa

mSystems, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading the activation gasdermin D (GSDMD) secretion pore-forming domain GSDMD

Язык: Английский