Investigative Ophthalmology & Visual Science,
Год журнала:
2023,
Номер
64(6), С. 2 - 2
Опубликована: Май 1, 2023
Myopia
typically
starts
and
progresses
during
childhood,
but
onset
progression
can
occur
adulthood.
The
goals
of
this
review
are
to
summarize
published
data
on
myopia
in
young
adults,
aged
18
40
years,
characterize
age
group,
assess
what
is
currently
known,
highlight
the
gaps
current
understanding.
Specifically,
peer-reviewed
literature
was
reviewed
to:
timeline
stabilization
juvenile-onset
myopia;
estimate
frequency
adult-onset
evaluate
rate
regardless
onset,
both
college
years
later;
describe
axial
elongation
myopic
adults;
identify
risk
factors
for
adult
progression;
report
adults
who
have
undergone
refractive
surgery;
discuss
management
research
study
design.
Adult-onset
common,
representing
a
third
or
more
all
western
populations,
less
East
Asia,
where
childhood
high.
Clinically
meaningful
continues
early
adulthood
may
average
1.00
diopters
(D)
between
20
30
years.
Higher
levels
associated
with
greater
absolute
myopia-related
ocular
disease
visual
impairment,
thus
group
requires
ongoing
management.
Modalities
established
control
children
would
be
options
it
difficult
predict
their
efficacy.
feasibility
studies
limited
by
long
duration
required.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 4, 2025
A
multicenter
cross-sectional
study
was
conducted
to
investigate
the
magnification-corrected
association
between
fovea-disc
distance
(FDD)
and
optical
coherence
tomography
(OCT)-measured
macular
retinal
layer
thickness
in
eyes
with
without
primary
open-angle
glaucoma
(POAG).
12.0
×
9.0-mm-wide
swept-source
OCT
scan,
which
includes
both
macula
optic
disc,
performed
190
from
124
healthy
subjects
(normal
group)
149
117
POAG
patients
(POAG
group).
The
FDD
of
nerve
fiber
(mRNFL),
ganglion
cell
inner
plexiform
(GCIPL),
outer
retina
(OR,
total
minus
(mRNFL
plus
GCIPL))
were
measured
corrected
for
magnification
effects.
mixed-effects
models,
accounting
potential
confounding
factors,
revealed
two
significant
associations
a
longer
thickness:
thinner
mRNFL
normal
group
(coefficients,
-3.14,
95%
confidence
intervals
(CI),
-4.75
-1.53;
p
=
0.0001)
GCIPL
-4.26;
CI,
-6.85
-1.67;
0.0013).
varies
by
presence
POAG.
can
significantly
affect
OCT-determined
thickness,
especially
eyes.
Investigative Ophthalmology & Visual Science,
Год журнала:
2024,
Номер
65(5), С. 25 - 25
Опубликована: Май 17, 2024
Purpose:
To
quantitatively
characterize
retinal
changes
across
different
quantiles
of
refractive
error
in
34,414
normal
eyes
23,064
healthy
adults
the
UK
Biobank.
Methods:
Twelve
optic
disc
(OD),
foveal
and
vascular
parameters
were
derived
from
color
fundus
photographs,
correcting
for
ocular
magnification
as
appropriate.
Quantile
regression
was
used
to
test
independent
associations
between
these
spherical
equivalent
refraction
(SER)
34
(high
hyperopia
high
myopia)—controlling
age,
sex
corneal
radius.
Results:
More
negative
SER
nonlinearly
associated
with
greater
Euclidian
(largely
horizontal)
OD-fovea
distance,
larger
OD,
less
circular
more
obliquely
orientated
OD
(superior
pole
tilted
towards
fovea),
brighter
fovea,
lower
complexity,
tortuous
vessels,
concave
(straightened
out
fovea)
papillomacular
arterial/venous
arcade
wider
central
arterioles/venules.
In
myopia,
varied
strongly
myopia
increased.
For
example,
while
every
standard
deviation
(SD)
decrease
complexity
0.63
D
(right
eye:
95%
confidence
interval
[CI],
0.58–0.68)
0.68
(left
CI,
0.63–0.73)
higher
quantile
corresponding
−0.60
D,
it
1.61
1.40–1.82)
1.70
1.56–1.84)
most
myopic
quantile.
angle
(degree
vertical
separation
found
vary
linearly
SER,
but
magnitude
little
practical
importance
(less
than
0.10
variation
per
SD
change
almost
all
quantiles)
compared
distance.
Conclusions:
Several
interrelated
indicative
an
increasing
(nonconstant)
rate
mechanical
stretching
are
evident
at
posterior
increases.
These
also
suggest
that
stretches
predominantly
temporal
horizontal
direction.
Investigative Ophthalmology & Visual Science,
Год журнала:
2024,
Номер
65(2), С. 21 - 21
Опубликована: Фев. 9, 2024
Purpose:
The
purpose
of
this
study
was
to
investigate
the
incidence
and
characteristics
posterior
vortex
veins
(PVVs)
in
healthy
eyes
explore
their
relationship
with
age
refractive
status.
Methods:
This
retrospective
cross-sectional
analysis
encompassed
510
from
255
consecutive
participants.
Wide-field
optical
coherence
tomography
angiography
(WF-OCTA)
imaging
used
assess
presence
PVVs.
Eyes
were
classified
according
status
(emmetropia,
low
moderate
myopia,
high
myopia)
(minors
adults).
PVVs
analyzed.
Results:
Participants
(mean
=
30.60
±
21.12
years,
47.4%
men)
showed
a
mean
error
−2.83
3.10
diopters
(D;
range
−12.00
+0.75).
observed
16.1%
(82/510)
eyes.
Of
these,
39%
(32/82)
had
one
eye
61%
(50/82)
both
number
per
1.65
1.05
(range
1–6).
are
mainly
around
optic
disc
(78%,
64/82)
less
macular
area
(6.1%,
5/82)
or
elsewhere
(15.9%,
13/82).
PVV
correlated
status:
10.3%
(22/213)
emmetropia,
16.6%
(31/187)
26.4%
(29/110)
myopia
(P
0.001),
but
not
age.
Refractive
key
predictor
occurrence
(odds
ratio
[OR]
1.45,
95%
confidence
interval
[CI]
1.02–2.06,
P
0.038).
Conclusions:
confirms
PVVs'
eyes,
highlighting
inherent
existence
susceptibility
alterations
due
conditions.
These
findings
enhance
our
understanding
vein
system
its
distribution
within
Journal of Personalized Medicine,
Год журнала:
2025,
Номер
15(1), С. 15 - 15
Опубликована: Янв. 2, 2025
Purpose:
Choroidal
thickness
(ChT)
is
an
important
measurement
for
evaluating
eye
and
systemic
disorders,
but
it
influenced
by
numerous
elements,
especially
axial
length
(AL).
It
known
that
the
presence
of
a
linear
relationship
between
ChT
AL
exists,
recently
has
been
shown
obtained
with
current
optical
biometry
not
very
precise
needs
to
be
corrected.
This
study
aimed
verify
if
similar
correlation
also
persists
this
corrected
(ALc).
Methods:
All
subjects
underwent
complete
examination,
including
spectral
domain
coherence
tomography
(OCT)
enhanced
depth
image
(EDI)
mode
IOLMaster.
After
normality
check
data,
correlations
ALc
were
investigated
through
Pearson
coefficient.
p
values
<
0.05
considered
statistically
significant.
Results:
In
total,
100
eyes
50
healthy
patients
evaluated.
The
mean
was
24.36
±
1.23
mm
24.25
1.22
mm.
nasal
ChT,
subfoveal
temporal
were,
respectively,
250.57
93.93
µm,
307.18
101.66
313.72
88.86
µm.
A
significant
negative
found
comparing
both
(all
r
-0.500,
all
0.050).
stronger
=
-0.581).
Conclusions:
Through
OCT
biometry,
we
confirmed
equal
uncorrected
AL.
On
these
bases,
in
studies
or
protocols,
recommend
stratifying
population
according
because
still
present;
however,
cut-off
should
changed
systematic
errors
biometry.
addition,
changes
evaluated
ALc.
Ophthalmology Science,
Год журнала:
2025,
Номер
5(3), С. 100695 - 100695
Опубликована: Янв. 5, 2025
To
explore
the
curvature
distribution
in
posterior
eye
among
school-aged
children
using
distortion-corrected
widefield
OCT
and
its
relationship
with
biometric
variables.
Cross-sectional,
observational
study.
Eighty-eight
children.
A
swept-source-OCT
prototype
system
a
repetition
rate
of
400
kHz
was
used
to
capture
retinal
images
field-of-view
68
×
degrees.
The
acquired
were
corrected
for
distortion
ocular
optical
information
obtained
separately
each
eye.
represented
by
Gaussian
which
derived
from
Bruch's
membrane
segmentation.
mean
assessed
across
4
regions
set
centered
on
fovea,
considering
axial
length
(AL),
refractive
error,
age,
choroidal
thickness
(ChT).
Additionally,
we
identified
entry
site
long
ciliary
artery
(LPCA)
into
choroid.
Local
total
176
eyes
imaged,
7
excluded
due
low
image
quality.
Analysis
169
revealed
bilateral
symmetry
vascular
patterns
curvature.
Significant
correlations
noted
between
AL,
ChT
superior,
macular,
inferior
regions.
However,
temporal
region
exhibited
reversed
correlation
trends.
local
maximum
point
commonly
observed
region,
potentially
linked
LPCA
site.
Our
study
provided
quantitative
analysis
children,
highlighting
region.
Interestingly,
relationships
variables
contradicted
those
other
3
Further
investigation
is
necessary
elucidate
origin
implications
development.
Proprietary
or
commercial
disclosure
may
be
found
Footnotes
Disclosures
at
end
this
article.
Optometry and Vision Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
SIGNIFICANCE:
Atropine
is
effective
at
slowing
myopia
progression
in
children,
but
the
mechanism
of
action
by
which
it
controls
remains
unclear.
This
article
an
evidenced-based
review
potential
receptor-based
mechanisms
atropine
may
act
to
slow
myopia.
The
rising
number
individuals
with
worldwide
and
association
between
vision-threatening
ocular
pathologies
have
made
control
treatments
one
fastest
growing
areas
ophthalmic
research.
High-concentration
(1%)
most
treatment
for
date;
low
concentrations
(≤0.05%)
appear
partially
are
currently
being
used
children.
While
significant
progress
has
been
past
few
decades
understanding
fundamental
myopia,
precise
characterization
how
works
incomplete.
It
plausible
that
slows
via
its
affinity
muscarinic
receptors
influence
on
accommodation,
animal
studies
suggest
this
likely
not
case.
Other
shown
that,
addition
receptors,
can
also
bind,
or
affect
of,
dopamine,
alpha-2-adrenergic,
gamma-aminobutyric
acid,
cytokine
progression.
summarizes
atropine’s
effects
different
receptor
pathways
tissues
discusses
these
contribute
Given
relatively
broad
array
implicated
a
single
mode
unlikely;
rather
be
exerting
directly
indirectly
several
multiple
levels
tissues,
all
trigger
response
same
direction
inhibit
eye
growth
