International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1388 - 1388

Опубликована: Янв. 26, 2022

The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport water across biological membranes in response to osmotic pressure gradients as well enable transmembrane diffusion neutral solutes (such urea, glycerol, and hydrogen peroxide) ions. AQPs expressed throughout human body. Here, we review their key roles fluid homeostasis, glandular secretions, signal transduction sensation, barrier function, immunity inflammation, cell migration, angiogenesis. Evidence from wide variety studies now supports view functions being much more complex than simply mediating passive flow membranes. discovery development small-molecule AQP inhibitors for research use therapeutic will lead new insights into basic biology novel treatments range AQP-associated disorders.

Язык: Английский