The role of retinal pigment epithelial senescence and the potential of senotherapeutics in age-related macular degeneration
Survey of Ophthalmology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
METTL3‐mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2‐dependent manner
Xianrong Du,
Yinguang Guo,
Xiaoqin Zhao
и другие.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(10)
Опубликована: Сен. 12, 2024
Macrophage
polarization
and
inflammation
may
play
an
important
role
in
the
development
of
sepsis.
T-cell
immunoglobulin
mucin
1
(TIM1)
has
been
demonstrated
to
promote
macrophage
inflammatory
responses.
However,
whether
TIM1
regulates
affect
sepsis
remains
unclear.
Human
monocytic
leukemia
cell
line
was
induced
into
macrophages,
followed
by
stimulated
with
LPS
IL-4
induce
M1
M2
polarization.
The
expression
levels
TIM1,
methyltransferase
3
(METTL3),
insulin
like
growth
factor
2
mRNA
binding
protein
(IGF2BP2)
were
examined
qRT-PCR
western
blot.
IL-6,
IL-1β,
TNF-α
tested
ELISA.
CD86
Язык: Английский
The Emerging Role of IGF2BP2 in Cancer Therapy Resistance: From Molecular Mechanism to Future Potential
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12150 - 12150
Опубликована: Ноя. 12, 2024
Tumor
resistance
is
one
of
the
primary
reasons
for
cancer
treatment
failure,
significantly
limiting
options
and
efficacy
therapies.
Therefore,
overcoming
has
become
a
critical
factor
in
improving
outcomes.
IGF2BP2,
as
reader
m6A
methylation,
plays
pivotal
role
post-transcriptional
regulation
RNA
through
methylation
sites.
It
not
only
contributes
to
initiation
progression
but
also
key
tumor
drug
resistance.
This
review
provides
comprehensive
summary
mechanisms
by
which
IGF2BP2
therapy
resistance,
with
aim
chemotherapy
treatment.
Advancing
research
this
area
crucial
developing
more
effective
therapies
that
could
improve
quality
life
patients.
Язык: Английский